- Acting for Two: Kurt Russell returns to voice Ego in this episode, and also voices his ship's AI when trying to find Peter.
- The Other Darrin: Annette Bening is replaced by Keri Tombazian as Wendy Lawson.
- Role Reprise:
- Laurence Fishburne and Madeline McGraw return to voice Bill Foster and young Hope van Dyne after last playing them in Ant-Man and the Wasp.
- Atandwa Kani reprises his role as young T'Chaka from Black Panther as well, stepping in after his father briefly stood in for him in the second episode of the first season.
- Gene Garber voices Vasily Karpov for the first time since Captain America: Civil War, though he's never seen onscreen and is only named as the Winter Soldier's Handler in the credits.
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