Trivia / The Break-Up

• Dueling-Stars Movie: Vince Vaughn vs. Jennifer Aniston, especially after they became a couple in real life while doing this film.
• Romance on the Set: Vaughn and Aniston became a couple in real life while doing this film.
• Separated-at-Birth Casting: Vince Vaughn and Vincent D'Onofrio have been mistaken for each other for years, so it naturally made sense to cast them as brothers in this film.