- Box Office Bomb: Budget $8 million. Box office, $10,375,893. Dan Aykroyd's career barely slowed due to his film Trading Places becoming a huge hit just a few weeks after this film was released. Director Michael Pressman wasn't so lucky, it would be thirteen years before he directed another film.
- Romance on the Set: Dan Aykroyd married Donna Dixon shortly after making this film, first proposing to her at co-star Fran Drescher's home. They would do Spies Like Us and The Couch Trip together.
- Star-Derailing Role: If it weren't for Trading Places being a hit a month later, Doctor Detroit would have stopped Dan Aykroyd's post-John Belushi career before it began. Paramount executives were actually worried about Trading Places's prospects due to this film's poor reception.
- Stillborn Franchise / What Could Have Been: The ending just before the credits promised that Doctor Detroit would return in a sequel titled Doctor Detroit 2: The Wrath of Mom. It started as a parody on Star Trek II: The Wrath of Khan, but later the studio was seriously considering it because they expected the film to be a huge hit. Dan Aykroyd was even working on the screenplay himself. Unfortunately, the film did not do well at the box office and the proposed sequel was scrapped.
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