Good Lord, the entire movie. Almost every frame is oozing with dread.
The spider motif, which becomes more disturbing almost every time it comes up. Needless to say, if you're an arachnophobe, it would most likely be best to steer as far away from this movie as possible.
The first instance is in the opening scene, which depicts Anthony entering a sex club, and then watching intensely as a naked woman prepares to step on a tarantula, firmly establishing the tone of the movie.
The second time involves Jake Gyllenhaal walking down a hallway as a woman passes by. As she comes into focus, it becomes clear that not only is she naked, she has the head of a spider.
The third instance is a Big-Lipped Alligator Moment depicting an utterly massive spider towering above a city.
Finally, we have the most infamous scene in the movie, in which Adam receives an envelope containing a key. After a moment's worth of hesitation, he asks Helen, who is in another room, if she has any plans for the evening. When she doesn't respond, he enters her room, only to find a giant tarantula in her place. Roll Credits.
