- Kei and Akiteru Tsukishima from Haikyuu!!
- The Armstrong siblings (oldest to youngest from right to left) from Fullmetal Alchemist
- Clown brothers
- Rigby and Don from Regular Show
- 19 year old Luisa (left) and and 21 year old Isabela from Encanto
- Ella and her "little bro" Tuck from PAW Patrol
http://tvtropes.org/pmwiki/pmwiki.php/ImageLinks/BigLittleBrother
FollowingImage Links / Big Little Brother
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