- Isaac's editorial in "The Six Southern Gentlemen of Tennessee":Jeremy: Isaac, no fooling; play of the year.
- Jeremy's speech to Natalie in "Shoe Money Tonight":Jeremy: I want you to trust me right now. I want you to say to yourself, yes, I've dated a string of jerks in my life, they were stupid, they were mean to me, but maybe this one's different. Maybe I should take a chance and not adopt the break-up-with-him-before-he-breaks-my-heart strategy. I want you to remember that when I started liking you, I didn't stop liking tennis. And I want you to know that I don't think there's a woman in the world that you need to be threatened by, no matter how glamorous you think she is. But mostly, I want you to trust me, just once, when I tell you that you have three sevens, and I have a straight.
- Sam Donovan's dismissal of the meddlesome executives near the end of the episode "Cliff Gardner":Sam: One last thing. The first and last decision-making authority on this show will rest with Isaac Jaffee until Isaac Jaffee says otherwise, and if you disrespect him in my presence again, I will rededicate the rest of my life to ruining the rest of yours. And if you think I'm just mouthing at you, you should ask around about me. I have absolutely no conscience about these things.J.J.: Sam, why did you bring us out here?Sam: Because there's the exit. That's it. The meeting's over.
- Dan casually brought up Rosa Parks during an argument with Isaac, naively comparing his struggle with network executives to her struggles in the civil rights movement. Isaac ignores the comment, and they ultimately come to a peaceful compromise. However, as Dan is leaving Isaac's office, we're treated to this legendary (and justified) gentle-but-firm verbal smack-down by Jaffee:Isaac: Danny, you know I love you, don't you? And because I love you I can say this: no rich young white guy has ever gotten anywhere with me comparing himself to Rosa Parks. Got it?
Awesome / Sports Night