History Main / TamperingWithFoodAndDrink

* There's also putting sharp objects such as needles and razors in food.
** [[WhyFandomCantHaveNiceThings A notorious incident]] in the ''VideoGame/{{Undertale}}'' fandom was when a fan-artist was offered cookies from a fan at a fan convention, only for it to turn out that said fan ''put needles in the cookies'', all because ''[[DieForOurShip they didn't like the fan artist's ship]]''. And ''yes'', the fan artist got [[TongueTrauma injured]], but they survived.
** In Fall 2018, Australia suffered from numerous incidents of strawberries with needles in them, followed by copycat incidents such as also doing it to mangos.

* ''WebVideo/EconomyWatch'':
** In "The Lottery", the show's tenth episode, David is poisoned with cyanide and dies after refusing to take part in a lottery.

** A nearly identical mode of operation was used by [[https://en.wikipedia.org/wiki/Blanche_Taylor_Moore Blanche Taylor Moore]], who would ultimately be charged with first-degree murder in the deaths of first husband James Taylor[[note]]not to be [[NamesTheSame confused with]] the singer Music/JamesTaylor[[/note]] (whose demise was first thought to be a heart attack) and boyfriend Raymond Reid (initially believed to be from Guilian-Barre syndrome; a seldom-fatal ailment) via arsenic poisoning, along with the attempted murder of her last husband, Rev. Dwight Moore, who survived the poisoning attempt; eventually being convinced in Reid's murder and sentenced to death in early 1991[[note]]Moore is still on death row in North Carolina; but as of this writing is in her late eighties and has had numerous health problems in recent years; making it more likely she would end up dying of natural causes rather than execution[[/note]]; and in addition has been the subject of suspicion in the death of her father (reportedly to have died from a heart attack; with apparently no evidence having surfaced to dispute the initial reported cause of death).

* ComicBook/GrantMorrisonsBatman has Red Hood poisoning Blackgate Prison inmates this way, with 82 confirmed dead and hundreds more in critical condition as part of his gambit to kill everyone in it.

* ''Wiki/SCPFoundation'': The Foundation has been known to dose witnesses of [=SCPs=] with amnesiac drugs, or even just conventional psychedelics, and occasionally their own agents too. The presenter at their UsefulNotes/{{Memetics}} and Infohazards Division [[http://www.scpwiki.com/memetics-and-infohazards-division-orientation orientation session]] is very open about the hallucinogens in the food there and assures them [[GoMadFromTheRevelation they'll need it]].

Compare RevengeIsADishBestServed, when someone puts something gross (but non-fatal) in food or drink to get back at someone (usually [[UnsatisfiableCustomer a grumpy or bossy customer]]). CleanFoodPoisonedFork is when the means of eating the food is tampered for the same effect. TaintedTobacco is where the poisoner tampers with the victim's smoking material rather than their food.

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[[folder:Anime & Manga]]
* ''Manga/AttackOnTitan'': [[spoiler:Zeke]]'s spinal fluid allows him to Titanize Eldians at will, utilizing wine that had been laced with his fluid and served to numerous higher ups within the military, essentially making all of the infected his hostages.
* ''Anime/BloodC'': One of the reasons for Saya's frequent memory loss is due to [[spoiler:Fumito putting drugs, sometimes blood which would help with Saya's blood dependence, in her coffee and marshmallows]].
* This is a rather common killing method in ''Manga/CaseClosed''. However, more of the cases are actually subversions of this trope since the poison was not put on the food directly but in objects the killer knows their victims would touch before eating their foods.
** A {{filler}} Valentine's Day episode has a mother try to collect insurance money by poisoning her {{Jerkass}}-ish adopted son's coffee. The antidote was in the cake's icing--the lad, being on his uni's tennis team [[RealMenHateSugar and professing hate for all kind of sweets]], didn't eat the cake. Additionally, she also poisoned a half-eaten bar of chocolate and switched it with one that was given to the victim as Valentine's gift by his crush, in an attempt to frame the girl, since the lady knew [[ThroughHisStomach the victim would take a bite of his chocolatey "enemy" to please her]]. And even more: a "friend" of the victim tried to tamper with the guy's cigarettes via poisoning the filters, but the would-be victim just cut said filters off in a whim and thus he failed.
** One example of such a subversion happens when [[spoiler:a JerkAss IdolSinger falls dead after eating some rice balls... but the poison was ''not'' originally in said snacks. It was placed in a specific spot of his jacket: the killer knew that [[FlungClothing the guy liked to melodramatically take off said jacket during a certain part of a song]], so they put it in that spot so he'd touch the venom and "transfer" it to the rice balls when he grabbed them to eat them.]]
* In the first ''VideoGame/FatalFury'' anime special, [[spoiler:Geese forces his sort-of protegé Lily to give Terry a bottle of poisoned wine. [[BrokenBird Lily]], [[HighHeelFaceTurn who has fallen for Terry]] and feels ''terrible'' because Geese used her to kill Terry and Andy's father years ago, cannot bring herself to let Terry fall in the trap and stops him from consuming it. Then she explains what happened and gives him AnguishedDeclarationOfLove.]]
* Subverted in ''Manga/FullmetalAlchemist''. When Roy Mustang gets offered tea by [[spoiler:Fuhrer Bradley, who knows that he knows that he's a homunculus and tried to tell Central Command about it]], he wonders if it's poisoned, but is told that it is not.
* In ''Anime/{{Gankutsuou}}'', Heloise receives a ring that contains poison from the Count. She uses it to poison some water she tried to give to Valentine, but Albert ends up drinking it instead. She also poisoned some lemonade which one of the household staff ends up drinking. She later mentions that she wanted to poison more people this way as well.
* In ''Literature/TheHeroicLegendOfArslan'', Arslan reveals to Gieve and Elam that his nursemaid and her husband died of drinking too much nabeed (wine) one day when he was younger, just prior to him starting to live at the palace. However, since they both died at the same time in a suspicious manner and [[spoiler: it's later revealed Arslan is not even Andragoras or Tamahine's son]], Gieve quietly suspected they were actually poisoned.
* In ''Manga/HonooNoAlpenRose'', [[spoiler:Mathilda]] tries to do this to [[spoiler:Jeudi]] by contaminating her food and tea during breakfast. Luckily, Printemps [[EvilDetectingDog sees this]] and attacks her, saving his owner. [[spoiler:It turns out this is how she routinely drugs Jeudi's mother Helene, slipping tiny quantities of poison in her tea to keep her permanently ill and vulnerable.]]
* One chapter of ''Manga/KaguyaSamaLoveIsWar'' has Miko refuse Kaguya's offer for a cup of tea on the suspicion that she would poison it.
* Putting harmful substances in food happens quite often in ''Manga/KindaichiCaseFiles''. For example, in "Santa's Slayings (European Hotel Murder Case)", a stage actress is murdered after drinking wine during a play in a scene where her co-performers also chooses randomly from a bunch of them. [[spoiler:The killer wrote a footnote in her script to pick a certain glass during that part. Since the victim could memorize lines only from reading once, the killer had no trouble disposing of it.]]
* In ''Manga/{{Monster}}'' Director Heinemann, Dr. Oppenheim, and Dr. Boyer are found dead after being mysteriously poisoned by candy left by Johan Liebert. Candy which was not only wrapped but in a ''sealed bag''.
* In ''Manga/MythicalDetectiveLokiRagnarok'', Skuld tries to do this to Loki on two occasions and fails miserably both times (in one incident, the person she brainwashes into delivering the poisoned food proceeds to explain what the food had been doped with immediately after delivery). She isn't very good at assassination--[[InLoveWithTheMark her heart just isn't in it]].
* In ''Manga/{{Naruto}}'', Tsunade poisons Jiraiya's drink, leaving him unable to fight at full strength against Orochimaru. It is implied that she was leaning toward accepting Orochimaru's offer at the time, then changed her mind later.
* ''Anime/NightHeadGenesis: Naoto and Naoya's parents drugged their melon sodas to subdue the boys so they could give them away to the laboratory.
* Happens plenty of times in ''Manga/OokuTheInnerChambers'':
** [[spoiler:Hisamichi]] slipped poison into the food and drink of Yoshimune's older sisters and the closest rival to the throne to ensure that Yoshimune got the shogunate. She has to clarify that she did ''not'' do that to Ietsugu, as Ietsugu was sick and not expected to make it to adulthood.
** Tokugawa Harusada, mother of Shogun Ienari, is quite fond of doing this to pick off rivals and control people. Her MoralEventHorizon is when she [[spoiler:slips poison into her grandchildren's sweets to kill them and turn her son's wife (Shigu) and favorite concubine (O-Shiga) against each other.]] What's worse is it's implied she did that because she was ''bored''.
** [[spoiler:However, Shigu and O-Shiga quickly figure out Harusada was behind those deaths and play a long game to poison Harusada in revenge. Part of that involves O-Shiga, now Harusada's taster, poisoning herself to ensure that Harusada would eat the poisoned food. She dies not long after the poisoning finally incapacitates Harusada.]]
** Unfortunately, this left a nasty legacy on Ienari's reign: his concubines quickly realized poisoning rivals was a quick way to get ahead, with the result that only about half of Ienari's numerous children made it to adulthood.
* The sociopathic protagonist in Creator/SuehiroMaruo's short ''[[http://samehat.blogspot.com/2005/10/poison-strawberry-chapter-one.html Poison Strawberry]]'' puts thumbtacks in her classmate's milk. What happens next is horrific.
* In ''Anime/PumpkinScissors'', one episode features a visiting princess from a neighboring country, with a particularly draconian rule of succession: Whichever royal child survives, takes the throne. Poison is a favored means of sibling rivalry, and she reveals that on her 10th birthday, the cake was poisoned, causing the death of her favorite maid. The fear of poison is so in-grown in her that even when eating a hot dog at a street-stand, where nobody knows who or what she is, she can't take a bite until somebody has tasted it for her first.
* Kodachi Kuno of ''Manga/RanmaOneHalf'' is a good cook who prepares elaborate meals, and she often uses culinary expertise to her advantage by placing poisons, toxins, serums, and other strange substances in her victims' food to attain something she wants from them.
* ''Manga/Reborn2004'': Bianchi, known as "Poison Scorpion Bianchi" in the Mafia underground, specializes in poison cooking; food items that contain poison and have a nasty color to them. Her food also has a tendency to ''melt'' its surroundings.
* ''LightNovel/RebuildWorld'':
** There is a RunningGag of the MundaneLuxury of good food putting TheParanoiac Akira into a daze of happiness, since he grew up in the slums with no access to decent food. When Akira is scheduled to meet a government executive over dinner, Akira’s EccentricMentor Kibayashi points out how sometimes high level hunters have their food tampered with to make them more pliable for negotiations, which prompts Akira to panic and demand the executive visit him in his HomeBase in the slums instead, creating some misunderstandings about Sheryl’s gang in the process.
** And then there's TheReveal [[spoiler:that the reason Akira became a DifferentlyPoweredIndividual able to connect to the old world domain was because the Rebuild Institute put their {{Nanomachines}} in the food of the slums as part of a bungled experiment that resulted in most subjects dying thanks to PowerIncontinence that was also responsible for Akira's DarkAndTroubledPast of being constantly betrayed.]]
* ''Manga/SakuraGari'':
** At one point, [[{{Yandere}} Sakurako]] feeds Masataka a piece of sushi. He quickly spits it out, revealing that Sakurako snuck in a piece of glass.
** It's later revealed that [[spoiler:Sakurako, who heavily resents her father for [[MadwomanInTheAttic locking her away]], convinced [[MasterPoisoner Katsuragi]] to slowly poison Lord Saiki by slipping him little bits of poison in his food. Had Katsuragi [[KarmicDeath not gotten his "just desserts" at the hands of Souma and his own wife Asayo]], the old man would've eventually died of both poisoning and his already present bad health.]]
** Subverted at some point: Sakurako ties up Masataka to a chair and [[ForceFeeding force-feeds him]], with Masataka expecting her to have slipped stuff in it again... but it's perfectly untouched food, and she made him believe it was tampered with [[ForTheEvulz to bully him]].
* ''Manga/SakuraNoIchiban'': In chapter seven, the third-year girls of the Sakura Blossom Club have their tea poisoned by the other members of the club so that they can become closer to Tsukiko and her wealth. Sanae is framed for the incident due to being from a poor family and generally disliked by most of the girls in the club.
* Raji of ''Manga/SnowWhiteWithTheRedHair'' poisoned a basket full of apples before sending them to Shirayuki. His plan was for her to be kidnapped and brought to him after the poison left her unable to fight back, but to his horror, he ends up poisoning the prince of the neighboring country instead.
* In ''LightNovel/TheStoryOfSaiunkoku'', Shuurei is the subject of repeated poisoning attempts during her time as Imperial Concubine. In the most notable instance she's presented with a cup of poisoned sake during a banquet; immediately suspicious but aware that refusing the offer would be a grave insult, Ryuuki drinks it in her place, counting on his better constitution and AcquiredPoisonImmunity to get him through it. It still makes him quite sick for a while, and when Shuurei finally finds out, she's torn between being impressed that he basically [[TakingTheBullet took the bullet]] for her, and being angry at him for taking such a risk. (Not because she's got ''feelings'' for him, or anything--it's just that the civil war that would result from his death would be really bad for the people. [[{{Tsundere}} That's all, really!]])
* ''Manga/TalesOfWeddingRings'': In the Land of Water arc, the fortune-teller first tries to get rid of Satou by having assassins poison his dinner. This fails because Saphir is wise to the fortune-teller's ways and warns Satou not to eat, with Alabaster confirming that the food has been tampered with a moment later. Hime and Nefritis then bring Satou an alternative meal which they prepared themselves and is thus safe to eat.
[[/folder]]

[[folder:Fan Works]]
* In both canon, and in the works of Creator/AAPessimal, the Guild of Assassins' School now has its Domestic Science department. As with any school teaching young ladies the rudiments of cooking and domestic management, a lot of what it does is unremarkable and straightforward and to be found in any girls' school anywhere. Until the girls enter the Fifth Year and go On The Black, that is. Then they learn other food-and-beverage-related skills.
* In ''Fanfic/BlindCourage'', a ForcedMiscarriage was attempted on 17-year-old Princess Zelda when she refused to abort a baby born out of wedlock. Poison was snuck into her food. Zelda fell into a coma but ultimately she and her daughter survived the poisoning.
* In ''Fanfic/DestinysKiss'', Princess Ting-Ting is killed when her tea is poisoned.
* In the eleventh chapter of ''[[Fanfic/BecomingFree Free]]'', Queen Elsa's chocolate is poisoned with a herb called frost-bane. Frost-bane is so hot that no frost can form on it, which makes it perfect to use against AnIcePerson like Elsa. Elsa {{faint|ing}}s and breaks out in a fever. After being comatose for several days, Kristoff comes back with Isfrukt berries to cure Elsa's ailment.
* Ludwig from ''Fanfic/AGameOfCastles'' poisoned his father's tea.
* At one point in ''Fanfic/IfTheyHaventLearnedYourName'', Barnes winds up [[ItMakesSenseInContext breaking into Sam's hotel room and presenting him with a container of macaroni and cheese with bacon]]. Sam's been craving macaroni and cheese for weeks, so he nearly snaps up the container before remembering that Barnes's allegiances are still unconfirmed, and asks Barnes if he put anything funny in the food. [[SubvertedTrope Barnes looks baffled and genuinely offended, and calmly asks Sam why he'd poison him when he has a perfectly good sniper rifle.]] Poison's tricky because the associated biochemistry isn't a sure thing, while a bullet to the head almost never goes wrong. Sam winds up eating the food.
-->'''Sam:''' Ah. Silly me. Why hand-deliver someone dinner when you can make their head explode from a mile away.
* ''Fanfic/JWITCHSeason1'' has a benevolent variant. While the heroes search for Meridian's missing heir, Uncle concocts for her a chi spell [[GoodHurtsEvil which will hurt evil magical entities that touch her]]. Once Elyon is confirmed to be the heir, the heroes trick her to drink the concoction by slipping it into a bottle of grape soda, her favorite drink. [[spoiler:Unfortunately, [[EvilSorcerer Daolon Wong]] concocts a counter-spell in the next chapter, and Cedric uses the exact same trick as the heroes to make Elyon drink it.]]
* This happens quite a lot in ''Fanfic/TheRigelBlackChronicles'':
** Harry's drink is invisibly turned into a powerful acid, but she's saved JustInTime by someone who heard about the plot. Her arm is splashed and burned, but that's easily fixed.
** She later stops [[spoiler: Tiberius Ogden]] from taking a drink spiked with Nimue's Breath, which is an anti-inhibitor, harmless in itself, but sometimes used to conceal the presence of more dangerous additives. [[spoiler: Sure enough, the drink turns out to contain nightshade.]]
** Before Leo defends his crown in the final match of the Lower Alleys duelling tournament, [[spoiler: someone spikes his fake rum to make him actually intoxicated. Harry is only able to partially counteract it before he has to fight]].
** Harry gives the Weasley Twins a bag of Bertie Bott's Every Flavour Beans coated with a potion that [[spoiler: [[CoveredInGunge causes them to pour floods of pink goo from every pore]].]]
* In the ''Fanfic/EmpathTheLuckiestSmurf'' story "Smurfnip Madness", Gargamel sprays smurfberries with concentrated [[FantasticDrug smurfnip]] essence so that the Smurfs will eat the berries and get high to the point where they start seeing [[MarijuanaIsLSD hallucinations]].
[[/folder]]

[[folder:Films -- Live-Action]]
* ''Film/TwelveHourShift'': Nurse Mandy offers coffee to the security guard watching over the hospitalized inmate, failing to mention she added morphine.
* Spoofed in ''Film/TheAddamsFamily'': Fester brought some cyanide with him when he moved in, with the implication that he'd poison the family this way. When Morticia finds it, she just smiles and asks if he thought they'd run out of it. The implication is the family uses cyanide as ''seasoning''.
* In ''Film/{{Andhadhun}}'', Simi pours poison into Akash's tea in front of his eyes ([[ObfuscatingDisability he's pretending to be blind]]). [[spoiler:After he "accidentally" spills the tea, he finds out that a sweet he ate earlier was also poisoned.]]
* In ''Film/TheAssassinationBureau'', Eleanora first poisons [[spoiler:her husband Cesare, the Italian assassin]], then prepares drinks for herself and Dragomiloff, slipping poison in his drink. Dragomiloff spins the table until it stops, picks up the goblet in front of him, drinks down the contents, and falls to the floor. [[spoiler:He was faking it.]]
* In ''Film/BattleRoyale'', Yuko Sakaki puts potassium cyanide in spaghetti that Yukie Utsumi's friends cooked for Shuya Nanahara. Yuko then tries to deliver the spaghetti to Shuya personally, but Yuka Nakagawa snatches it away and eats it. [[spoiler:She then suffers from the poisoning, vomits much of her blood out of her mouth, then quickly dies. This results in Haruka, Yukie, Chisato (but ironically, not Yuko) all getting shot by Satomi out of suspicion she can't trust any of the girls.]]
* In ''Film/BlindDate'', [[Creator/BruceWillis Walter]] uses a tiny syringe to put alcohol in chocolates he has delivered to Nadia because she has an extreme allergic reaction to alcohol.
* In the early Creator/PeterFalk flick ''Film/TheBloodyBrood'', Falk plays a psychotic beatnik who feeds some poor kid a hamburger filled with broken glass to watch him die... [[ForTheEvulz just for kicks]].
* One of the final revelations Detective Ma receives in ''Film/BloodyReunion'' is that the victims of the massacre [[spoiler:had all been poisoned before their bodies were mutilated]]. When he returns to the scene of the crime, he discovers that [[spoiler:the cake Mi-Ja served everyone]] had been poisoned.
* In ''Film/TheBody2012'', Álex spikes his wife Mayka's wine with TH-16: a cardie-toxin that causes a cardiac arrest 8 hours after ingestion. [[spoiler:He later learns that Carla/Eva spiked his own drink with TH-16 just before he left for the morgue: almost 8 hours earlier.]]
* In ''Film/CasinoRoyale2006'', Film/JamesBond gets an absolutely fatal dose of digitalis in his drink. It's subverted with the defibrillator/first aid kit in his car, and ''that'' in turn is subverted when he doesn't have it connected properly. Vesper Lynd's arrival is just dumb luck.
* The massacre of adults of Gatlin in ''Film/ChildrenOfTheCorn1984'' starts when some diner patrons start choking from their poisoned coffee.
* Downplayed and subverted in ''Film/ChildrensPartyAtThePalace''. The Grand High Witch planned to put her potion in the [[UsefulNotes/HMTheQueen Queen]]'s cake that would [[ForcedTransformation turn whoever eats from it into mice]], until she finds out there was no cake to begin with. Eventually the villains bake their own cake with her potion in it...but turns out the potion had no effect on the Goodies.
* ''Film/TheCourtJester'' combines this with PoisonedChaliceSwitcheroo.
-->The pellet with the poison's in the vessel with the pestle, the chalice from the palace has the brew that is true.\\
No! The Flagon with the Dragon holds the pellet with the poison, the vessel with the pestle has the brew that is true.
* In ''Film/TheCrimeDoctorsStrangestCase'', the bedbound Walter Burns is murdered by someone poisoning his coffee.
* In ''Film/CrookedHouse'', the murderer doses Josephine's hot chocolate with cyanide, although Josephine is not the one who ends up drinking it.
* In ''Film/DeadAgainInTombstone'', Zerelda attempts to dispose of Boomer by lacing his eggs with cyanide.
* The Axis powers in ''Film/FDRAmericanBadass'' attempt to covertly attack US by smuggling in tainted alcohol that can turn anyone consuming it to a werewolf.
* ''Film/TheFourMusketeers'' (1974). D'Artagnan receives a case of wine along with a note that indicates it's from his fellow Musketeers. Before he can drink any of it, an enemy {{mook|s}} drinks some and dies; it was poisoned wine sent by Milady to kill him.
* In ''Film/TheGentlemen'', Mickey has Lord George's tea poisoned, then leaves him with the antidote, the point having been to demonstrate that he could get to Lord George anywhere.
* In ''Film/GhostShip'' there's a flashback comprised of a montage of images of what occurred on the ocean liner. During this, there's a scene in the kitchen where cooks are putting rat poison in food. We then see passengers eating the food and one person vomits as a result.
* In ''Film/GoodBurger'', after many failed attempts at getting Ed to spill the beans of the secret recipe of his homemade sauce (which put Good Burger in business over Mondo Burger), Kurt, owner of the latter restaurant, and his employees lock up Ed and Dexter in the asylum and break into Good Burger, in which they douse the sauce with shark poison, hoping whoever devours some will file a lawsuit against Good Burger to put it out of business for good. Luckily, Dexter and Ed make it in time to break the news to the other employees before a single customer is able to eat a drop of the sauce.
* Done twice in Disney's ''Film/TheHauntedMansion'' with poison being put into goblets of wine.
* In ''Film/HesOutThere'', Maddy eats a poisoned cupcake that she finds in the woods, planted by the killer.
* In ''Film/AJollyBadFellow'', Bowles-Otterly poisons his first two victims by by slipping the poison into their drinks: giving Dr. Brass a glass of laced claret, and dosing Mrs Pugh-Smith's gin-spiked water.
* In ''Film/{{Kate}}'' the title character is a professional killer who discovers she has been poisoned with Polonium-204, giving her accute radiation poisoning. She quickly realises the culprit was a man she picked up for a one-night stand, though he'd been told by his employers he was SlippingAMickey instead.
* In ''Film/KillBill Vol. 2'', Elle Driver reveals that [[spoiler:she murdered Pai Mei by poisoning his fish heads]].
* ''Film/KindHeartsAndCoronets'': Unlike the more elaborate murders he concocts for his other targets, Louis disposes of the Reverend Lord Henry d'Ascoyne through the simple expedient of poisoning his wine.
* ''Film/KullTheConqueror'': Subverted. Kull and his friends board the ship of Juba, one of Kull's old associates from his days as a pirate, to travel to an island that contains the one weapon that can destroy the villainess. Juba serves them food and wine, which Kull suspects to be poisoned and only partakes after Juba drinks and eats from it himself. It turns out that the food wasn't poisoned, but it ''was'' [[SlippingAMickey drugged]]. Juba's men tie up Kull and his team while their boss is unconscious.
* Parodied and averted in ''Film/LemonadeJoe'', a relentless parody of TheWestern. Hogo Fogo has kidnapped [[DamselInDistress Winnifred]] and plans to subject her to a fate worse than death, but is eating dinner in the saloon first. His brother, the less evil saloon owner, says he thinks Hogo's disgusting. Hogo opens his ring, puts some powder into a glass of water, and mixes it in. It looks like he'll try to make his brother drink it; [[spoiler:however, he then drinks it himself, and burps. It was antacid. He keeps eating his dinner, glutton that he is.]]
* In ''Film/TheManWithNineLives'', Dr. Kravaal drugs the soup Judy serves the thawed {{Human Popsicle}}s to knock them out so he can use them as guinea pigs for his experiments.
* In ''Film/{{MFA}}'', Noelle spikes the drink of one of the frat boy rapists with a date rape drug, then holds him down so he chokes on his own vomit.
* ''Film/MrsDoubtfire'': Daniel Hillard spikes his ex-wife's new paramour's meal with pepper after overhearing him stress to the waiter to ''not'' put pepper on it, as he's allergic. Even though the whole sequence is PlayedForLaughs, they came pretty close to the possibly fatal consequences of such a prank -- upon tasting the pepper, the man almost immediately begins choking, prompting Daniel to say, "Oh no, I killed the bastard!"
* In ''Film/MurderAtTheBaskervilles'', Hunter is murdered when powdered opium is slipped into his curried lamb.
* ''Film/MurderByDeath'': Lionel Twain arranges for one of the cups of wine served to the guests to have a tasteless, odorless [[PoisonIsCorrosive acidic poison]] in it. It turns out to be a subversion: Twain made sure the cup with the poisoned wine was served to the one guest who could identify it.
* The horror movie ''Film/NightOfTheDemons1988'' features a mean old man who puts razor blades in apples on Halloween to do [[MoralEventHorizon terrible things to children]]. At the end of the movie, [[spoiler:his wife makes an apple pie out of the leftover apples, which he eats. [[HoistByHisOwnPetard The blades slash through his throat and leave him dead.]]]]
* In ''Film/RaidersOfTheLostArk'', an Arab working for the Nazis pours poison on dates in Sallah's house in the hope that Sallah and/or Indy will eat them. The monkey steals the poisoned dates instead.
* In ''Film/RehearsalForMurder'', Karen and Leo's motive revolves around them supposedly giving Monica a herbal tea to "calm her nerves", which was actually spiked to make her too sick to perform on opening night.
* In ''Film/Sahara2005'', we have a rare version where the perpetrator is one of the good guys; [[spoiler:Jim Sandecker gives multiple requests before he decides to do any more work for the US government, but we don't hear him say the last one; the next scene is Massarde being poisoned in a restaurant by Jim's ally, Carl.]]
* Creator/GuyRitchie's ''Franchise/SherlockHolmes'' duology:
** Being aware of this doesn't prevent it, as seen in ''Film/SherlockHolmes2009''. Irene Adler pulls a clever one on Holmes in using an ''unopened'' bottle of wine. A flashback reveals she used a syringe to inject a knockout drug through the cork, and a match to re-melt the wax and conceal the hole.
** At the beginning of the [[Film/SherlockHolmesAGameOfShadows next movie]], Irene is smart enough to ask for a fresh pot of tea when meeting with Professor Moriarty, rather than drinking from the one already on the table. [[spoiler:Unfortunately Moriarty has bought out the entire restaurant. All the potential witnesses get up and leave at his signal, and the new pot turns out to be poisoned. Cue SoundOnlyDeath.]]
* In ''Film/TheSixthSense'' one of the [[ItWasHisSled dead people the kid sees]] is a small girl who was poisoned by her mother putting cleaning fluid in her soup.
* ''Film/SympathyForLadyVengeance'': In prison, Geum-ja kills the Witch by adulterating her food with bleach. ''For three years!''
* Creator/JohnCarpenter's ''Film/TheThing1982'' has the characters being ProperlyParanoid about this -- one single cell could be enough to turn anyone into a Thing. "I think everyone had better prepare their own food from now on..."
* In ''Film/ThirteenWomen'', Ursula attempts to murder Laura's son Bobby by sending him a box of poisoned chocolates.
* ''Film/WeddingCrashers'': At dinner in one scene, John proceeds to spike Zach's water with eye-drops, which makes him sick, thereby letting John connect with Claire, Zach's fiance.
* In Film/TheThreeStooges short "[[Recap/TheThreeStoogesWhoDoneIt Who Done It?]]", the villainess prepares two drinks and slips poison in Shemp's drink. The two distract each other while they [[PoisonedChaliceSwitcheroo switch the goblets]]. Finally, Shemp drinks down the poison and goes through some hysterical death throes. Naturally, he recovers.
* ''Film/WildTales'': In ''Las Ratas'', the waitress refuses the cook's offer to put rat poison in Cuenca's food, but the cook poisons it anyway.
* ''Film/WildThings'': Double subverted. When after all the backstabbing between the conspirators only a final guy and girl are left, the guy is smart enough to expect the drink he's offered to be poisoned but is assured when the girl tells him that she would be an idiot to try it because he's the only one who can pilot the sailboat they're on back to shore. This is a lie--the drink is indeed poisoned, and the girl is much smarter than she made herself out to be. Just to be sure, she releases one of the booms to knock him into the water to drown.
* In ''Film/TheWitchFiles'', [[spoiler:Jules]] gives MJ a green smoothie laced with ergot. MJ, having been forewarned, tosses it in the bin as soon as she is out of sight.
* ''Film/TheWrestler'':
** [[spoiler:Jules]] gives MJ a green smoothie laced with ergot. MJ, having been forewarned, tosses it in the bin as soon as she is out of sight.
** Randy, in his day job at the deli counter of a local grocery store, encounters a particularly indecisive elderly lady who keeps asking for "a little more" or "a little less" potato salad. Annoyed at her, he discreetly licks a few dips of his gloved fingers as he's disposing of excess. He later on proceeds to cut some meat and intentionally slice his fingers open and bleed on everyone in a ScrewThisImOuttaHere move.
* This is Graham's standard M.O. in ''Film/TheYoungPoisonersHandbook'': poisoning food and drink. Tea is his most common medium, but he also uses sandwiches, chocolates, pickles, beer, etc.
* Johnny from ''Film/TheBigCube'' slips LSD into people's drinks at parties. He's kicked out of medical school after one of his victims runs into traffic and dies. Later, he and Lisa hide LSD inside Adriana's anxiety pills.
[[/folder]]

[[folder:Literature]]
* Willard Price's ''[[Literature/AdventureSeries African Adventure]]''. While they're on safari in Uganda, someone tries to kill Hal and Roger Hunt by putting ground-up leopard whiskers in their food.
* Creator/AgathaChristie was so incredibly fond of poisons; it's the most common way for victims to die.
** In ''Literature/CrookedHouse'', one of the two murder victims is poisoned by spiking a cup of cocoa with digitalis.
** The victim of ''Literature/FiveLittlePigs'' had poison put in his drink. [[spoiler: He also had a harmless but unpleasant substance put in another drink, which confuses the issue.]]
** In ''Literature/TheMysteriousAffairAtStyles'' it's subverted. [[spoiler:One of the characters believes poison was put into the first victim's drink and tries to cover up any clues that would led Poirot to this conclusion.]]
* ''Literature/AndThenITurnedIntoAMermaid'': After Molly's falling-out with Ada, Molly's sister Margot puts cayenne pepper in Ada's ketchup, knowing how much she hates spicy food.
* At the climactic Elstyn family meeting in ''[[Literature/AuntDimity Aunt Dimity Takes a Holiday]]'', only Simon, the recipient of the threatening notes, takes a cup of tea offered by the maid. That maid is revealed to be [[spoiler:Derek's insane former nanny, who targeted Simon in the belief that he was trying to take Derek's inheritance]]. She says of Simon: "I tried to warn him, but he wouldn't listen. Won't listen, must be made to listen." Then she audibly whispers to Derek: ''"Make him drink his tea..."'' After she leaves the room, an Inspector from Scotland Yard asks everyone to avoid touching the teacup, since the police intend to have it analysed.
* In ''Literature/BattleRoyale'', Yuko Sakai, mistakenly believing Shuya Nanahara killed another classmate in an altercation (the death was actually accidental), attempts to poison Shuya's meal with potassium chloride while he's recovering at a lighthouse where she and her friends are holed up. Another friend eats the meal instead, her subsequent death causing a chain reaction that leads to all of Yuko's friends [[MexicanStandoff shooting and killing each other]] and Yuko, herself, being DrivenToSuicide.
* ''Literature/BazilBroketail'':
** General Hektor is poisoned along with other officers by wine Ourdhi civilians give them. A couple die and he falls into a coma, leaving General Paxion in command with a difficult time.
** A group of dragons and dragonboys are drugged with doped beer while in Ourdh. When they fall asleep, Relkin and Bazil are kidnapped to serve as sacrifices.
* ''Literature/TheBelgariad'': This trope is the reason members of the Nyissan court take poison antidotes daily. Sadi appears to be as good as any full-time assassin at it--he muses once about having poisoned the soup course in front of his victims without being caught, and in ''The Malloreon'' he slips knockout drugs to ''an entire army''.
* The Prince Consort, husband of the queens and father of the princesses, of ''Literature/ABrothersPrice'' was killed via poisoning while on a picnic. [[spoiler:A PersonalEffectsReveal later reveals that his son-in-law Keifer did it]].
* In ''[[Literature/AdventuresOfADemonHuntingSoccerMom Carpe Demon]]'', Kate slips holy water into normal goblets of water when she tries to catch a suspected demon-occupied person in mixed company.
* ''Literature/TheCatWhoSeries'': In book #19 (''The Cat Who Tailed a Thief''), [[spoiler: Lynette Duncan]] is murdered when arsenic is slipped into her food [[spoiler: by her new husband]] while on her honeymoon.
* Creator/DavidMorrell
** ''Testament'' opens with the protagonist noticing that his cat has dropped dead after drinking from its bowl. He suddenly realises the milk has been poisoned (this was when milk was delivered to your door in bottles) but is too late to stop his wife from feeding their baby son from his baby bottle. Things don't improve from there as his family is being targeted by a right wing terrorist organisation.
** In ''The Fraternity of the Stone'', a monk notices that a mouse that he's been feeding has died. His food was poisoned [[KillEmAll along with everyone else's in the monastery]]--he's a former ProfessionalKiller who had a HeelFaithTurn and was the intended target.
* ''Literature/ADearthOfChoice'': When the dungeon starts growing food crops, some of them turn out as normal high-quality plants, but others are corrupted by their high mana levels and the murderous System behind the dungeons, becoming rotten, toxic, diseased, or cursed with even nastier effects like turning people directly into undead. The dungeon assigns one of his minions to identifying and removing the dangerous plants, hoping to provide the healthy ones to the nearby village.
* Literature/{{Discworld}}:
** In ''Literature/InterestingTimes'' an Agatean courtier tries this on Cohen the Barbarian. It doesn't work and the courtier finds himself having a terminal case of indigestion when the tables are turned. Also worth noting that Cohen is strongly averse to this sort of thing. He'll happily kill dozens at a meal, usually by getting them drunk first and then killing them in their sleep... but you don't poison the food.
--->"Barbarians didn't poison food. You never knew when you might be short of a mouthful yourself."
** A similar thing happens in ''Literature/{{Mort}}''. The GrandVizier tries to poison the Emperor, but he tries to do it in a very elaborate way: he claims he found the poisonous object in his ''own'' food, but that only the Emperor is worthy of it. They go back and forth on who should eat it for quite some time (Mort, because he can't leave until someone dies, even [[LampshadeHanging says]] "Would ''someone'' just eat it?"), but finally the Grand Vizier has to eat it, then tries to leave, leading to this:
--->'''Grand Vizier:''' Urgent matters of state, my lord.\\
'''Emperor:''' Would these be the urgent matters of state in a little bottle marked "Antidote" on your dresser?
** Tampering with food and drink was also a popular tactic of the wizards in the early books (before they mellowed out and became a satire of modern academia). There was even a saying: When a wizard is tired of looking for broken glass in his dinner, he is tired of life.
** In ''Literature/UnseenAcademicals'', Glenda, a SupremeChef, visits Vetinari with a homemade pie. One of Vetinari's advisors suggests that Glenda may have poisoned the pie, an idea that Ventinari correctly dismisses, as she treats cooking almost like a religious vocation and would regard this as a crime against food.
** This trope is referenced but ultimately [[AvertedTrope averted]] in ''Literature/FeetOfClay''. [[spoiler:The candle wicks are laced with arsenic instead, releasing the poison into the air as they burn down.]]
* Nobles in the ''Franchise/{{Dune}}'' universe so frequently used poisoning to further their schemes that they had different terms for poisons used this way: poison someone's drink, and it's called chaumurky, but if you put poison in solid food it's chaumas.
* {{Downplayed|Trope}} in ''[[Literature/TanteiTeamKZJikenNote The Egg Hamburg Steak Knows]]'', where a truck driver of the meat processor, [[spoiler:in a LethallyStupid way to PokeThePoodle, spiked some of the beef shipped to the plant with pork out of spite]]. The bad news is it caused [[PlotAllergy allergic reaction]] on a certain [[HotBlooded Kazuomi Wakatake]]...
* ''Literature/{{Eisenhorn}}: Malleus'' opens with the titular Inquisitor having been poisoned this way three days prior, and has him launch a desperate raid on the poisoner's hideout in search of an antidote.
* ''Literature/SimonArk'': In "The Faraway Quilters", the VictimOfTheWeek has her drink spiked with chloral hydrate, which causes her to pass out and fatally wreck her car.
* ''Literature/GirlsDontHit'': Joss uses poison she's placed surreptitiously in targets drinks to kill them more than once.
* ''Literature/TheGirlWhoDrankTheMoon'' has a scene where Ethyne offers Gherland a cup of tea. Gherland then perceives Ethyne as fearsome and is easily plied for information.
* In one of ''Literature/TheGreatMerlini'' short stories, the poison is added to the sugar packet the victim adds to his coffee.
* ''Literature/HarryPotterAndTheHalfBloodPrince'':
** Ron Weasley swallows a poisoned drink that was actually meant for Dumbledore and almost dies. (And this was just ''after'' Ron ate a love-potion hidden in candy that was meant for Harry; don't side-kicks ''ever'' learn they're just fall-guys?)
** Dumbledore discloses to Harry in one of their private sessions about a more deadly example of this. Hepzibah Smith, the featured character [[spoiler:alongside Tom Riddle Jr., AKA [[BigBad Voldemort]]]] in the PensieveFlashback during said session, died from a poisoned drink mere days after the scenario shown in said PensieveFlashback took place. Her personal House Elf, from whom Dumbledore procured the memory, was tried and convicted of AccidentalMurder, but Dumbledore suspects (and Harry agrees) that said House Elf was merely [[FrameUp framed]] for Hepzibah's murder and that the Ministry of Magic officials didn't bother looking more closely into the case [[FantasticRacism "because she was a House Elf"]].
** On a more positive note, Harry exploits this trope to make Hermione and Ron think he added his good luck potion to Ron's drink. [[MagicFeather Thinking he has good luck on his side]] gives Ron the confidence boost he needs to win the Quidditch match.
* ''Literature/JaineAustenMysteries'':
** Quinn Kirkland from ''Last Writes'' dies after eating a doughnut covered in rat poison.
** Marybeth Olsen from ''The PMS Murder'' is killed by guacamole laced with peanut oil, triggering a fatal allergic reaction.
** Bunny of ''Death of a Trophy Wife'' dies when her martini is spiked with weed killer. [[spoiler:It's revealed that it wasn't meant for her martini to be poisoned, but rather Lance's]].
** Joy Amoroso of ''Killing Cupid'' is killed from chocolate injected with cyanide. [[spoiler:It's meant to be [[LaserGuidedKarma poetic justice]], as she had poisoned Skip Holmeier's cat Miss Marple by feeding her chocolate.]]
** Dean Oliver from ''Murder Has Nine Lives'' is killed from eating [[ItMakesSenseInContext diet cat food sprayed with a can of odorless Raid.]]
* ''Literature/JamesBond'':
** Bond is saved from being eaten by wolves in ''Literature/{{Brokenclaw}}'' thanks to his ally Rushia, who threw steaks dosed with Chloral to their cage beforehand.
** Staying at a hotel in ''Literature/DeathIsForever'', Bond and his partner Easy order sandwiches. When they are about to eat them, they find out that someone has planted eggs of [[SpidersAreScary poisonous spiders]] on them, which were supposed [[AnimalAssassin to hatch and kill them]] after ingestion.
** The bad guys in ''Literature/TheFactsOfDeath'' attempt to kill thousands of northern Cypriots by spraying anthrax inside a ship full of food cargo.
** The rations of a Chinese mountaineering expedition in ''Literature/HighTimeToKill'' are destroyed by contaminating their food with piss and setting the sacks containing them on fire.
* In ''Film/TheKillersCousin'' by Nancy Werlin, [[spoiler:Lily accidentally killed her sister by putting cleaning solvent in a glass of water. It was supposed to have been a prank, as she didn't think her sister would really drink it.]]
* ''Literature/TheManyHalfLivedLivesOfSamSylvester'': [[spoiler:Carl murdered Billy by putting peanut oil on his popcorn ball, as Billy was deathly allergic to peanuts. Decades later, he puts Sam's dad in the hospital by secretly adding walnut extract to his "nut-free" coffee cake.]]
* ''[[Literature/JohnPutnamThatcher Murder to Go]]'' had poison added to the seasoning mix for a spicy fast-food chicken dish. It wasn't ''supposed'' to be a lethal dose, but that's not the most precise method of faking a mass foodborne-illness situation. The mastermind should consider himself lucky only one person died.
* One victim in ''[[Literature/KateShugak A Night Too Dark]]'' is killed when her cookie is spiked with peanut oil to induce a fatal allergic reaction.
* ''[[Literature/TheTripods The Pool of Fire]]'': The WeaksauceWeakness of the alien Masters is discovered accidentally when a drunken guard pours his booze into the food being taken to a Master who has been captured by LaResistance. Attempts have been made to discover their vulnerabilities, but the Master has always detected the poison and refused to eat, so the protagonist just takes the food in, expecting the Master will reject it as usual. He falls into a coma instead. However, actually getting the alcohol into the Masters' water supply proves exceptionally difficult, as it means infiltrating their DomedCity and distilling alcohol in an alien environment. And even once this is achieved, they have a city full of sleeping Masters who might rouse at any moment, and the small infiltration force has [[AndThenWhat no idea what to do next]].
* In ''Literature/TheQueensThief'', the new King of Attolia has to put up with having sand in his food all the time as a prank by his attendants (and the kitchen staff, who prefer the queen). When this is revealed to the guard captain, it raises the possibility of more sinister things being added to the plate. [[spoiler:Attolis puts up with it to build evidence against one of his queen's enemies, and finally puts a stop to it by visiting the kitchen staff two books later to reveal that he was once a phony kitchen boy that bit their previous, hated head chef.]]
* Francesca tries multiple times to unnerve her interview subjects or throw off her coworkers like this in ''Literature/RamaII'', once leading to a [[spoiler:false diagnosis of appendicitis in the team leader for an expedition, hoping that Brown would get to go instead and fulfill a term in their backroom contract with an outside entity. Since the robot surgeon killed the man when Rama made a sudden maneouvre during surgery, her plan killed him. She covers up his murder, and might not be remorseful for it; her plan worked in that, following the leader's death, Brown did go on the sortie.]]
* In ''Literature/RedSeasUnderRedSkies'', Archon Stragos serves Locke and Jean cold cider after several hours in an overheated room. The cider itself is fine, but the glasses were dosed with a poison that only Stragos has the antidote for, ensuring their service.
* In ''Literature/RiverOfTeeth'', Hero sneaks poison into the iced tea they offer Houndstooth during their first meeting, then demonstrates that it's safe by [[AcquiredPoisonImmunity drinking from the same glass]]. Since Houndstooth wants to hire Hero due to their reputation as a MasterPoisoner, he is not fooled and refuses the drink.
* In the first book of ''Literature/ASeriesOfUnfortunateEvents'':
** Violet thinks miserably that she should've poisoned the sauce she's serving with the pasta for Count Olaf and his troupe, considering how they are acting rude and refuse to eat the food the siblings made for them because they wanted roast beef instead.
** Violet believes Count Olaf poisoned the oatmeal he serves to her and her siblings one morning because he's frankly a horrible guardian who was never nice to them in the entire time they've known him. He quickly proves them wrong by eating one of the raspberries on top of the oatmeal, convincing the siblings that it's safe to eat.
* In Creator/RobertEHoward's ''Literature/ConanTheBarbarian'' story ''Literature/ShadowsInZamboula'', Zabibi slips her lover something. It drives him into a frenzy, which is not the effect she intended. (What, exactly, she did intend--well, the stories thrown about are numerous.)
* ''Literature/ASongOfIceAndFire'':
** The PlotTriggeringDeath of the series, that of Jon Arryn, was done via this. Jon was given a drink mixed with the Tears of Lys, a difficult-to-trace poison designed to kill as fast as possible, while making the victim look as if they die of natural causes. His wife, Lysa, tells her sister, Catelyn Stark, that this was done under the auspices of the Lannisters, who want to usurp King Robert by eliminating people close to him. [[spoiler:The Lannisters really do want to usurp the throne, but killing Jon wasn't part of their plan. It was Lysa herself who poisoned his drink; she was seduced by Petyr Baelish to betray her sister by misleading her, thus deliberately dragging the Starks into the conflict.]]
** An indirect example in ''Literature/AGameOfThrones''. Robert Baratheon is gored by a boar [[HuntingAccident during a hunting trip]], where he is more drunk than usual, and dies. In ''Literature/AClashOfKings'', Tyrion Lannister finds out that before the hunt, Robert was given a fortified wine three times its potency by Tyrion's cousin Lancel, who was given orders to do it by his sister and Robert's wife, Cersei. The boar was optional; all Cersei needed was Robert performing a reckless act that would kill him.
** Per Robert's orders, Varys sends an assassin to kill Daenerys Targaryen by gifting her a poisoned wine. However, the plan is thwarted by Jorah Mormont, who was the one spying on Daenerys for Varys in the first place, but [[InLoveWithTheMark has had a change of heart after spending time with her]], by preventing her from drinking it. It ultimately results in Khal Drogo's furious march to the west, his untimely death, Dany's meeting with Mirri Maz Duur, and the blood magic ritual she unwittingly uses to birth the dragons back to the world.
** In the prologue of ''A Clash of Kings'', Maester Cressen attempts to kill Melisandre using wine mixed with the Strangler, an extremely lethal poison which can induce choking on its drinker within seconds. Melisandre, being a powerful priestess, drinks most of it and comes out unharmed, then urges Cressen to drink the rest (he originally offered her to share the drink). He tastes a sip and dies instantly.
** King Joffrey Baratheon is poisoned during his wedding feast in ''Literature/AStormOfSwords'', in what the fans dub the "Purple Wedding". As it turns out, he was poisoned using the Strangler, as well; the crystals were hidden in a hairnet given to Sansa Stark by Ser Dontos, who in turn received it from Baelish. Olenna Tyrell discreetly took one of them from Sansa, then dipped it into a wine Joffrey was about to drink.
** In the closing days of the Dance of the Dragons, Aegon II Targaryen was poisoned less than a year after he fed his half-sister Rhaenyra to his dragon. Who exactly did the deed is unknown, but it's likely a conspiracy to assassinate him brewed when he refused to heed Corlys Velaryon's advice to abdicate, instead threatening to cut off and send Rhaenyra's son Aegon (the future Aegon III)'s ear to her ally Cregan Stark as a warning, therefore dragging the conflict further. Many people, both Blacks and Greens, were tired of the war and just wanted to end it already.
* In the ''Literature/LordPeterWimsey'' novel ''Strong Poison'' the victim died of arsenic poisoning. [[spoiler:It was put into the cracked egg that was made into an omelette, which he shared with his cousin (the murderer, who had built up an immunity to it over time so he could vouch that the poison wasn't in that particular meal)]].
* In ''Literature/SummersAtCastleAuburn'', the Crown Prince is poisoned at his wedding feast, despite his using a taste tester and without anyone else at the feast dying. Only two people figure out who did it, and only one of them figures out how: The poisoner put the poison in the main course, of which the prince was certain to have a large helping. The poisoner then put the antidote for the poison in the water pitchers. Since the prince never drank water (due to a paranoid belief that someone had tried to poison the well years previously, despite considerable evidence to the contrary), he was the only person at the feast who took the poison but did not take the antidote as well.
* In ''[[Literature/EddieLaCrosse The Sword-Edged Blonde]]'', it's done to a whole village with poisoned wine. The poison doesn't kill directly but incapacitates well enough that one mercenary can kill the whole population without resistance.
* ''Literature/TeaShopMysteries'':
** In ''Death by Darjeeling'', Hughes Barron is killed when the murderer slips poison into his tea.
** In ''Dragonwell Dead'', Mark Congdon suffers what appears to be a heart attack after drinking some iced tea. It's latter confirmed that there was a toxic substance within his drink.
* In the ''[[Literature/CormoranStrikeNovels Cormoran Strike]]'' novel ''Literature/TroubledBlood'', this is revealed to be the [[spoiler:M.O. of Janice Beatty, the [[MasterPoisoner serial poisoner]] who is ultimately discovered to be the culprit in the Margot Bamborough case.]]
* The romance novel ''Literature/WhisperToMeOfLove'' has a young woman's maid placing poison in her milk. Poison that she thinks is an antidote to a drug supposedly being given to her by her lover to trick her into a relationship with him (she has been told all this by the novel's villain, who wants to kill the heroine in order to claim her inheritance). What saves her life is the arrival of the hero, just after she's poured some milk out into a saucer for the cat. As the two sit and chat, he is horrified to see that the cat has died after drinking the tainted milk.
* In ''Literature/WingsOfFire'', Peril has been told by Queen Scarlet that she needs to eat coal or she'll die. When Peril stops eating coal for a day, she gets sick. It isn't until later that Peril learns that she's perfectly healthy. On that day Scarlet had poisoned her food to make her go back to eating coal.
* In ''Literature/TheWitches'', the Grand High Witch gives [[BigEater Bruno Jenkins]] a candy bar laced with Formula 86, which turns people into mice. She tells him to come to the ballroom in two hours to get more chocolate; when he does, the potion kicks in. The Witches' plan is to poison enough candy to turn ''all'' of England's children into mice, but in the end, they only succeed on Bruno and [[NoNameGiven the boy protagonist]], who comes up with a plan involving some food tampering of his own to defeat the witches.
* ''Literature/WarriorCats'':
** In ''Shattered Sky'', Violetpaw hides poppy seeds in the prey meant for [[BigBad Darktail]] and his henchmen in order to make them fall asleep, but unfortunately she's seen doing so and they don't eat it.
** In ''The Raging Storm'', Juniperclaw sneaks deathberry seeds into the prey [=SkyClan=] caught in the hope of killing them. One cat falls ill but survives.
* ''Literature/WilderGirls'':
** The reason Welch throws away most of the food that arrives in the boat drops, even though the girls at the school are going hungry: [[spoiler: to sabotage the government's efforts to conduct tests on the girls via contaminated food.]]
** [[spoiler:Headmistress has been holding back supplies and food and keeping them in her office, in case she needs to escape. Reese and Hetty are set to distribute the bottles, but notice that they have broken seals and a black powder in the bottom. It's gunpowder, which will kill whoever drinks the water.]]

[[folder:Live-Action TV]]
* In ''Series/TheATeam'' episode "[[Recap/TheATeamS3E6DoubleHeat Double Heat]]", it's subverted as a part of the scheme. Hannibal, posing as a waiter, takes a bite of the sandwiches Mr. Olsen ordered up to his room and fakes choking, causing the Federal agents to hustle Mr. Olsen to safety, fearing a security breach. Hannibal, of course, is just fine and simply wanted Olsen out of harm's way.
* ''Series/AlienNation'': In the television movie "The Udara Legacy" Susan recalls having poured a substance on some food meant for the Overseers, and that the Overseer who consumed the food she poisoned died a few minutes later.
* In ''Series/BabylonFive'', Londo makes a request of Lord Refa to break the association with [[spoiler:the Shadows]], and explains why he believes Refa will cooperate:
-->'''Londo:''' Because I have asked you, because your sense of duty to our people should override any personal ambition, and because I have poisoned your drink.
* In the second episode of ''Series/TheBorgias'', there's some poisoned wine at a banquet; it's intended for Pope Alexander, but Cesare brought a monkey to test it and when the monkey dies, Cesare and his father avoid the wine and storm out.
* ''Series/BreakingBad'':
** Walter attempts to kill Tuco by slipping ricin into his burrito while Tuco's back is turned, [[SubvertedTrope but he's foiled]] by Hector, whom he thought was senile, who notices Walt adding something to Tuco's lunch. Although Hector can't talk, he uses his bell to convince Tuco to switch lunches with him and then knocks the burrito onto the floor, clueing Tuco in that Walter and Jesse are up to no good.
** A non-fatal version occurs in "Fly", as Jesse is noticing that Walt has gotten incredibly obsessive over [[FlyCrazy trying to kill a housefly]] that's gotten into the lab, even spending a whole night up trying to catch it. He attempts to force Walt to go to sleep by slipping sleeping pills into his coffee. They start taking effect at the worst possible moment however, as Walt is steadying a precarious ladder so Jesse can reach the fly while struggling to even keep his eyes open.
** This is part of Walter's endgame plan in the GrandFinale. Knowing she's a CreatureOfHabit, he takes out Lydia by spiking the Stevia at the table she always sits at with ricin, dooming her to a slow death.
** Gus Fring takes out [[spoiler: Don Eladio, his clan and the remaining member of the Salamanca family (aside from Hector) with a poisoned bottle of Zafiro Añejo. Gus Fring drinks the tequila as well to avoid suspicion, he took a pill to minimize its effect and vomits it up a few minutes later, but still has to be hospitalized for its lingering effects.]]
* ''Series/BurnNotice'' has Michael slip peanuts into the dinner of a mercenary with an allergy. He then steals the man's [=EpiPen=] and interrogates him before he falls into anaphylactic shock.
* ''Series/{{Castle}}'':
** In "The Late Shaft", the VictimOfTheWeek is killed when the murderer spikes his cranberry juice with balsamic vinegar, which has a fatal interaction with his medication.
** In "The Squab and the Quail", the VictimOfTheWeek is killed by poison sprayed upon an appetizer in an exclusive restaurant.
* Used as an important plot point in ''Series/Chelmsford123'' [[spoiler:when Grasientus attempts to poison an entourage from the local British tribe]].
* ''Series/TheCoroner'': In "That's the Way to Do It", the VictimOfTheWeek has their food spiked with shellfish to trigger a fatal allergic reaction. However, someone else murders them before the allergic reaction can take effect.
* ''Series/{{CSI}}'' has a case where one juror wants to induce an allergic reaction in another but decides not to at the last minute.
* ''Series/{{CSINY}}'':
** In one episode, a guy dies of anaphylactic shock when two others prank him by sneaking lobster broth into his soup even though they know he's allergic to shellfish.
** In "Blood Actually", a woman murders her diabetic husband by giving him a 2 lb box of chocolates with a sugar-free label on it. Actually, they are normal chocolates. She also replaces his insulin with a sugar syrup, so when he injects himself, he just shoots up more sugar.
* ''Series/Daredevil2015'': In season 1, Madame Gao and Leland Owlsley make an attempt to kill Wilson Fisk's girlfriend Vanessa Mariana by spiking her champagne and the champagne of some other guests at a gala that Fisk is hosting. It fails, as Fisk rushes Vanessa to the emergency room in time for the doctors to pump her stomach.
* ''Series/DeathInParadise'': In "Damned If You Do...", the killer poisons the stew being eaten by everyone in an attempt to make the murder look like food poisoning.
* ''Series/DeadMansGun'': In "Black Widow", Lillian Posey poisons her husband by using a hypodermic to inject poison into a sealed bottle of wine through the cork.
* In ''Series/TheDickVanDykeShow'' episode "[[Recap/TheDickVanDykeShowS4E16TheImpracticalJoke The Impractical Joke]]", Rob brings Buddy some jelly donuts, which Buddy refuses to touch, believing they're somehow related to the payback he expects. Rob and Sally have to bite into all three of them to prove nothing's wrong, which of course leaves them useless for Buddy anyway.
* ''Series/DoctorWho'':
** In "[[Recap/DoctorWhoS4E6TheMoonbase The Moonbase]]", the Cyberman contaminate the base's sugar supply as a means of spreading their virus.
** In "[[Recap/DoctorWhoS30E7TheUnicornAndTheWasp The Unicorn and the Wasp]]", the Tenth Doctor drinks "sparkling cyanide". He survives it in a true SugarWiki/{{Funny Moment|s}}.
** In "[[Recap/DoctorWhoS31E12ThePandoricaOpens The Pandorica Opens]]", River Song purchases a Vortex Manipulator, offering to exchange it for a Callisto Pulse, a device that can disarm micro-explosives.
--->'''Dealer:''' What kind of micro-explosives?\\
'''River:''' The kind I just put in your wine.
* ''Series/{{Endeavour}}'': In "Arcadia", an extortionist who is targeting a supermarket has planted tainted products on their shelves, putting arsenic in the bloater paste and crushed glass in the baby food.
* ''Series/{{Fargo}}'': Happens in the [[Series/FargoSeasonThree third season]], where [[BigBad V.M. Varga]] has [[spoiler:Sy Feltz]] drink tea filled with an unknown chemical. This causes [[spoiler:Sy Feltz]] to fall into a months-long coma.
* ''Series/FatherBrown'': In "The Blood of the Anarchists", Titan--who is allergic to nuts--is murdered by someone spiking his hip flask with crushed almonds.
* In the ''Series/FrontierCircus'' episode "The Shaggy Kings", a renegade Indian poisons the circus's meat supply in order to force them to divert to Adobe Walls.
* In ''Series/TheGlades'' episode "Marriage Is Murder", the VictimOfTheWeek is an AmoralAttorney who had his drink spiked with antifreeze. However, someone else stabbed him before the poison could take effect.
* In ''Series/TheHauntingOfHillHouse'', [[spoiler: Olivia attempts to kill Luke, Nelly and Abigail. She fills a teapot with rat poison and takes them all to the Red Room for a tea party. Abigail, who is the daughter of the property groundskeepers, drinks the tea and starts to choke. Hugh rushes in before Luke and Nelly drink their tea and smacks them out of their hands. Abigail dies and Olivia realises the weight of her actions.]]
* ''Series/{{House}}'': At least one PatientOfTheWeek turned out to have been poisoned by his wife after House and his team had ruled out everything else. She did get arrested for it, although they never found out ''why'' she was doing it.
* In ''Series/{{Justified}}'', Mags Bennett kills one of her henchmen by sharing moonshine with him before revealing that the ''glass'' he was drinking out of was already poisoned, due to a combination of growing marijuana without her permission, calling the Marshals on another of her henchmen (admittedly a sex offender, but the principle stands), and due to Mags being a bit of a MamaBear to his teenage daughter whom he had been [[ParentalNeglect neglecting]] due to being stuck in mourning over his wife's death. [[spoiler:At the end of the season, she and Raylan share that same moonshine... and she [[DrivenToSuicide gives herself the poisoned glass]].]]
* Played with in the comedy series ''Series/LimmysShow:''
** In a scene parodying ''Film/IndianaJonesAndTheTempleOfDoom'', two dubious characters (perhaps spies), stand by a fireplace and make a toast 'to life.' They have a drink, retaining eye contact. One of the spies (played by Limmy) then pulls out a vial of green liquid (the antidote to the poison he just drank). The spy who drank the poison pulls out a vial of his own (also an antidote). They then awkwardly swap the vials and drink them. The first spy pulls out another vial, as does the second spy. They take their own antidotes and grab their drinks again, but hesitate to consume them.
** After a couple breaks up, they have one last drink before the boyfriend leaves. Out of his view, the girlfriend squeezes a drop of strychnine into one of the glasses and gives it to him. His hand slips and he accidentally drops it. Rather than having a new drink, he leaves. Following this, he is driving his car when he slowly grasps his face as if overcome by illness. Eerie music accompanies the scene. He then sneezes. He arrives home, then suddenly clutches his chest. His eye twitches and the music cues again, but really, he was searching his pockets for his wallet. Next, he lies in bed with his eyes wide open. His hand slowly falls to the ground, only to grab hold of his iPod. He puts earphones in his ears, and finally, looks at the camera to say:
--> "Why are you still here? You know she didn't get me, you saw the glass drop on the ground, are ye' daft?"
* In the 1989 Italian/Australian mini-series ''Series/TheMagistrate'', the wife of the title character has her shopping bag stolen, only for it to be returned by a bystander who chases the thief. She doesn't know it's a set-up to switch her tin of coffee, which has a bomb inside. TheMafia knows the investigating magistrate they're trying to kill always makes his own coffee; unfortunately, his wife decides to make some herself and gets killed.
* ''Series/MajorCrimes'': The VictimOfTheWeek in "Cheaters Never Prosper" is an out-of-town cop who is killed when his drink is spiked with antifreeze.
* ''Series/{{Merlin|2008}}'' has an attempt on Arthur's life via a poisoned chalice.
* The first crime in the ''Series/MidsomerMurders'' episode "A Vintage Murder" involves the wine being served at a wine tasting at a winery being poisoned.
* Occurs for a few of the murders on ''Series/MurderSheWrote''. In one case, the tampering just created a case of ''attempted'' murder, because another person actually killed the victim before he got to his poisoned brandy.
* ''Series/MurdochMysteries'': In "[[Recap/MurdochMysteriesS3E3VictorVictorian Victor, Victorian]]", Victor is murdered by the killer smearing crushed peanuts inside the skull cup he has to drink from as part of the Masonic initiation, which triggers a fatal allergic reaction.
* In ''Series/MythQuest'', Seth poisons Osiris's dates and feeds them to him at a ceremony, in order to kill him and gain his kingdom.
* ''Series/MyLifeIsMurder'': In "Lividity in Lycra", the killer swaps the VictimOfTheWeek's water bottle with an identical one spiked with monkshood. However, they miscalculate the dose and it is not enough to kill their target, and they are forced to finish the job by hitting him on the head with a rock.
* ''Series/{{Oz}}'':
** Nino Schibetta ate grounded glass that Ryan and Adebisi secretly put into his food for months until he dies from internal hemorrhaging, suddenly realizing one day that he's bleeding from the ears, nose, mouth...
** Also done to Supreme Allah in a more organic fashion. Once it's discovered that he's fatally allergic to eggs and must have his food cooked separately... Yeah, no more Supreme Allah.
* Both played straight and faked in ''Series/PersonsUnknown''.
** Erika gets Joe to confess this way.
** Later [[spoiler:Joe helps Janet fake her death by pretending to do this to a liquor bottle]].
* ''Series/PlanetEarthDynasties'': The lions inadvertently eat poisoned meat after coming across cows illegally grazing on lion territory. ''Most'' of the pride survives it.
* ''Series/TheProfessionals''. In "Not A Very Civil Civil Servant", an [[YouKnowTooMuch accountant]] who [[TheAlcoholic keeps a bottle of whiskey stashed in the greenhouse]] has it spiked with weedkiller. The bottle is then replaced with an untampered whiskey bottle to make it look like he committed suicide by drinking the weedkiller.
* This trope is used several times over the course of ''Series/ResurrectionErtugrul'', with such examples as:
** When Aytolun attempts to murder her husband Korkut in season 2 by [[spoiler:poisoning water intended for both herself and the Bey, while making sure she gets less of the poison in order for her to survive the symptoms. She succeeds at both.]]
** Sadettin Kopek attempts this twice, both times targeting the Sultan. [[spoiler:While the first one gets undone by Ibn Arabi, he is triumphant the second time around.]]
** In Season 5, Dragos manages to add toxic substances to [[spoiler:Teokles's water, eventually killing him during his stay at the Kayi tribe]].
** A non-fatal example occurs in Season 5 when [[spoiler:Sirma tosses an excessive amount of salt into Hafsa Hatun's soup, intent on making Selcan direct her displeasure toward Hafsa and thereby driving a wedge between them]].
* ''Series/ShakespeareAndHathawayPrivateInvestigators'': In "The Rascal Cook", a restaurant is sabotaged when the soup is spiked with syrup of ipecac. Later, the chef is murdered by being served a poisoned cup of coffee.
* ''Franchise/StarTrek'':
** In the ''Series/StarTrekTheOriginalSeries'' episode "[[Recap/StarTrekS1E13TheConscienceOfTheKing The Conscience of the King]]", someone tries to murder Kevin Riley by putting tetralubisol (a shipboard lubricant) in his milk. Tetralubisol is a milky white substance, so MakeItLookLikeAnAccident also applies.
** In the ''Series/StarTrekTheNextGeneration'' episode "[[Recap/StarTrekTheNextGenerationS4E7Reunion Reunion]]", the Klingon Chancellor K'mpec tells Picard that someone has been adding a poison to his bloodwine for months. The amount of poison itself was very small, but over time it built up to a point where it would be fatal.
** ''Series/StarTrekDeepSpaceNine'':
*** "[[Recap/StarTrekDeepSpaceNineS01E05Babel Babel]]" has a [[YourTerroristsAreOurFreedomFighters terrorist]] device that spikes the food and drink replicators with an aphasia virus being attached to the replicator systems during the station's construction. It winds up not being dispersed at the time because the virologist who planted it got captured. After Starfleet takes control of the station, O'Brien accidentally trips the device while making repairs to the replicators, and it eventually becomes aerosolized.
*** "[[Recap/StarTrekDeepSpaceNineS05E19TiesOfBloodAndWater Ties of Blood and Water]]" features a bottle of poisoned kanar. Weyoun gleefully downs a shot of the kanar just to demonstrate that his people are immune to poison.
* The main reason Louie hired Rev. Jim Ignatowski as a cab driver in ''Series/{{Taxi}}'' was because Jim slipped something in his coffee. When asked what it is, Jim just shrugged and said it could have either been a tranquilizer or a giblet. When Louie began tripping, Alex just said, "I guess we can rule out giblet."
* Happens by accident on ''Series/UntoldStoriesOfTheER'', when some student nurses practice injecting insulin into oranges, only for one such orange to be left in the break room. One of the students mistakes it for hers, eats it, and nearly dies of hypoglycemia.
* ''Series/TheVeil'': In "Food on the Table", Captain John Elwood takes his wife with him on a long voyage under the pretext of patching up their marriage and uses the opportunity to slowly poison her.
* ''Series/{{Vera}}'': In "Young Gods", the killer spikes the VictimOfTheWeek's drink with atropine. They try the same thing on a second victim, and it nearly does in him and Vera, who was sharing a drink with him. They survive because Joe is with them and calls for an ambulance.
* The Kingdom in ''Series/TheWalkingDead'' have their swine eat walkers before they're shipped off to the Saviors as tribute.
* In the ''Series/Warehouse13'' episode "The Ones You Love", Tracy tries to kill her sister Myka under the influence of an {{artifact|OfDoom}} by giving her coffee spiked with a drain cleaner. Instead, it ends up spilled on the floor, where it burns right through the carpet.
* Poisoning was one of the more common methods of murder used in ''Series/WhodunnitUK'', probably because it allows for the broadest possible suspect pool.

[[folder:Music]]
* Music/KingDiamond's album ''Abigail II: The Revenge'' has Abigail tricking Jonathan into eating food with glass shards on it after he rapes her in the songs "Broken Glass" and "More Than Pain".
* The Music/MelanieMartinez song "Milk And Cookies" is about a woman poisoning the cookies of a man who kidnapped her.
-->Do you like my cookies?\\
They're made just for you\\
A little bit of sugar\\
With lots of poison too.
* In the music video for Music/NoDoubt's "It's My Life" (pictured above), Gwen Stefani mixes rat poison into a man's dinner to kill him.
* Music/{{Saga}}'s song "Perfectionist" has the protagonist murdering his dinner guests by serving poisoned wine.
* In the song ''Music/ToKeepMyLoveAlive'', at least three times: to Sir Charles, Sir Frank and his ladies, and Sir Curtis.
* In Music/TheChicks' "Goodbye Earl," best friends Mary-Anne and Wanda kill Wanda's abusive husband Earl by poisoning his black-eyed peas.
* Music/CarrieUnderwood's "Church Bells" has the protagonist murder her abusive husband by slipping poison in his whiskey.

[[folder:Radio]]
* An old radio mystery involved a subversion of this: A man was found locked in a room full of food, yet somehow dead of starvation. The solution: [[spoiler:His murderer locked him in the room and lied to him about the food being poisoned. He believed the killer and refused to eat the food, so he eventually starved to death.]]
* ''Radio/{{Earthsearch}}''
** In Season One the Angel computers are secretly putting drugs in the food to repress the crew's puberty to keep them under their control. However Darv and Astra find the food galleries on the spaceship and start eating the food before it's been processed [[TemptingApple because it tastes better]].
** In Season Two the Angels decide certain crewmembers [[YouHaveOutlivedYourUsefulness have outlived their usefulness]] and contaminate their food, but have to intervene to stop someone they want to keep alive from taking a bite off their plate. After that everyone makes sure to only eat food they've taken right off the trees in the food galleries.

[[folder:Religion]]
* ''Literature/TheBible'': The Psalmist in [[Literature/BookOfPsalms Psalm 69:21]] (Evangelical Heritage Version) says, "They put bitter poison in my food. For my thirst they gave me sour wine to drink."

[[folder:Tabletop Games]]
* The video that accompanies the ''TabletopGame/ClueVCRMysteryGame'' (and forms part of the gameplay) includes a dinner scene in Boddy mansion where almost all of the guests end up poisoning something that is served at dinner.
* ''TabletopGame/DungeonsAndDragons'' once had "ingestive" (swallowed) poisons that could be added to food or drink. One article in Dragon magazine #59 had several dozen examples, and a Dragon #69 article extensively described seven such poisons.
* One of the ways to mess with the other players in ''TabletopGame/RedDragonInn'' is to play cards to spike their drinks, pushing them closer to passing out and being eliminated from the game.
* In ''TabletopGame/WerewolfTheApocalypse'', one of the Wyrm's most powerful servants is a global megacorporation named Pentex. Pentex has several subsidiaries devoted to alcoholic beverages, including King Beer, Ruskaiya Distilleries, and Dragon Valley Wines. The beverages they distribute are intended to physically and spiritually corrupt drinkers. King Beer is more likely than other beer to bring out the worst behavior in its drinkers. King Spirits occasionally contain teratogens and [[OurDemonsAreDifferent banes]]. Thaw Beverages' soda potentiates any banes clinging to its drinkers. Dragon Valley Wines are carcinogenic, and its Pyrrus line of wines turns the drinker into a beacon for nearby banes and increases their vulnerability to [[DemonicPossession possession]].

[[folder:Theatre]]
* In "The Ballad of Sara Berry" from ''Theatre/ThirtyFiveMillimeterAMusicalExhibition'', Sara poisons Patricia's cup of punch at the HighSchoolDance, killing her.
* In the play ''Holy Ghosts'', one character talks about his prizewinning dog, who was killed by jealous rival dog-owners by putting glass in his food.
* In ''Theatre/ThePajamaPartyMurders'', [[spoiler:Lola, disguised as Myrtle,]] attempts to poison the Cosmo heirs with arsenic in [[spoiler:the ice cubes in the drinks she's pouring]].

[[folder:Urban Legends]]
* In the U.S., many people believe stories about psychopaths [[RazorApples deliberately putting poison, razor blades and so on in candy given to children on Halloween]].
** [[https://www.snopes.com/horrors/poison/halloween.asp Poisons]]
** [[https://www.snopes.com/horrors/mayhem/needles.asp Pins and needles and razor blades, oh my]]
** [[https://www.snopes.com/rumors/candy.asp Terrorists buy candy in bulk just before Halloween]]

[[folder:Video Games]]
* In ''VideoGame/TwoDark'', an alternate way of dealing with Sylvia Scarlett is to place rat poison in her cake before it's sent upstairs through the food elevator. The player can poison her assistant/girlfriend's champagne alongside it as well.
* The online game ''Allergy Assassin'' has you play an assassin who specializes in eliminating targets via their allergies. Thus you have to figure out who your target is of the people in the room, what they are eating and what they are allergic to. In most cases, a successful kill has the target's allergy kick in as they eat, causing them to turn purple and pass out. (There are two exceptions where you must slip laxatives into their food so they must run to the bathroom and get attacked by bees or cats.)
* ''Franchise/AssassinsCreed'':
** In ''VideoGame/AssassinsCreedI'', Abu'l Nuqoud poisons the guests at his party with a wine fountain, which he reveals during his TheReasonYouSuckSpeech to them before he has his guards starting slaughtering them.
** ''VideoGame/AssassinsCreedBrotherhood'' has [[spoiler:Rodrigo Borgia]] attempt to kill [[spoiler:his son Cesare]] using this method and a poisoned apple, but he wounds up HoistByHisOwnPetard when the apples get forced into his mouth instead.
* ''Franchise/BaldursGate'':
** In ''VideoGame/BaldursGate'', your party gets poisoned around the time you get into the eponymous city, and you have to do a quest to get an antidote.
** In ''VideoGame/BaldursGateII'', when you reach the Asylum, you find out that [[spoiler:Yoshimo, or Saemon if you don't have Yoshimo,]] poisoned your food, [[spoiler:enabling Irenicus to capture you]].
* ''VideoGame/{{Ceville}}'' entails slipping Tabasco sauce into coffee.
* At the end of the Soviet campaign in ''VideoGame/CommandAndConquerRedAlert'', [[spoiler:Nadia]] successfully kills [[spoiler:Joseph Stalin]] by tricking him into drinking a poisoned cup of tea. At an earlier point in the campaign, [[spoiler:Marshal Gradenko]] is killed by the same person in the same way. It even features ''[[MeaningfulEcho the same dialogue]]''.
* In ''VideoGame/TheCurseOfMonkeyIsland'', you are required to drug yourself by [[DontTryThisAtHome mixing hangover medicine with alcohol]].
-->'''Guybrush:''' This makes the drink ''oh'' so much more appealing.
* ''VideoGame/DivinityOriginalSinII'': In one {{Sidequest}}, the player character can {{Item Craft|ing}} a special pie with [[TheDarkSide Void]]-tainted fish, feed it to an assassination target, and [[CampingACrapper Camp a Crapper]] during the resulting intestinal distress.
* ''VideoGame/DontEscape'': In the first game, the protagonist can combine meat and poison to make some bait in order to weaken his werewolf side.
* ''VideoGame/EtherOne'' has this as having happened to a mine warden (he apparently survived, but his incapacitation had severe consequences) when arsenic tablets were substituted for coffee filter cleaning tablets in a coffee machine. Whether or not this was intentional or accidental is unclear (evidence exists for either possibility).
* ''Final Cut: Death on the Silver Screen'': The PC discovers early in the game that her father's death was caused by medication tampering. (The game is set in the 1950s, which ''might'' justify the coroner not catching this before her.)
* ''VideoGame/FreeIcecream'': In order to get the duster from the killer's [[CatsAreMean cat]], you need to feed it a bowl of cat food laced with rat poison.
* In ''VideoGame/HarvestMoonDS'', you can do this at the Harvest Festival by adding a poisonous toadstool to the town's stew. Usually, doing this will result in the whole town falling ill (as well as making it taste like crap), but if you cultivate a level 99+ toadstool and add it to the stew, [[NonStandardGameOver the game ends]] with your character eating the stew, choking, collapsing, and dying, with the same fate suggested to befall the rest of the town.
* In ''VideoGame/HeroesOfMightAndMagic III'', this is how King Gryphonheart was killed.
* One of many methods of killing in the ''VideoGame/{{Hitman}}'' series is to put poison into food or drink that gets delivered to the target/victim. It's such a staple of the franchise that as of ''VideoGame/Hitman2016'', almost all of the story mission targets can be poisoned, as most of them eat or drink ''something'' as a part of their routine around a given part of the map. The recent games also add some variety with the use of emetic poison, which rather than killing people will cause them to go to the nearest bathroom to vomit, thus allowing you to drown them in a toilet.
* ''VideoGame/{{Kindergarten}}'':
** Nugget can trick the protagonist into eating a poisoned, well, nugget. Depending on your choices, he can then withhold the antidote until you [[spoiler:trick Buggs into eating another, more potent, one]].
** Ms. Applegate will serve you a poisoned meal if you have lunch with her after [[spoiler:turning down her offer to eliminate Buggs]].
* In ''VideoGame/KingsQuestIIIToHeirIsHuman'', you defeat Manannan by hiding a crumbled magical cookie in his porridge. When the unsuspecting wizard eats the porridge, the cookie [[ForcedTransformation turns him into a cat]].
* The protagonist of ''VisualNovel/KissOfRevenge'' favors poisoning as her method of taking revenge on the surgeon whose error killed her mother.
** In Issei's route, she gets her hands on some of his sleeping pills and replaces the contents of the capsules with poison; after missing a chance to slip the laced capsule back into his pill case, she tries to empty it into a glass of wine instead.
** In Junpei's route, she attempts to switch the director's diabetes medication for an antihypertensive that could cause a fatal reaction.
** In Irie's route, she tries lacing an insulin injection with poison, but gives up on the idea after Irie nearly catches her at it, making it too risky to try again.
** In Kyosuke's route, she poisons a glass of champagne. This attempt almost works, but [[spoiler:Kyosuke, guessing what she's up to, first contrives to make her spill some of the poison and then intercepts and drinks the doctored champagne himself]].
* ''VideoGame/{{Magicka}}'': Although this game is usually rather comedic, the ''Dungeons and Gargoyles'' DLC plays this trope for horror with the cultists of Old Aldrheim.
* In ''VideoGame/MitsumeteKnight'', [[spoiler:Raizze Haimer]] tries to kill Princess Priscilla by giving her a poisoned drink at the Princess's Birthday Party. Depending on your choices as the main protagonist, the Asian, it ends with either: Priscilla's [[spoiler:near-]]death, the Asian's near-death (as [[spoiler:Raizze]] will give him the antidote), or [[spoiler:Raizze]] spilling the drink to avoid the Asian being accidentally poisoned.
* In ''VideoGame/MysteryCaseFiles Ravenhearst'', In 1895, Emma falls very sick shortly before leaving England for home. Charles offers to let her stay at his mansion, Ravenhearst, "[[BlatantLies The House That Love Built]]", and personally prepares all her meals, in spite of the maid he hires to attend Emma. Through the course of the game, the Master Detective finds evidence that Charles was [[spoiler:making Emma sick, and at least some of the poison was being administered through her food.]]
* While fighting in the major leagues in the [[TournamentArc Glitz Pit]] in ''VideoGame/PaperMarioTheThousandYearDoor'', Mario gets sent two cakes from fans, the second one is laced [[spoiler: and was sent by the champion Rawk Hawk]]. If Mario eats it, his partner will be out for one Glitz Pit match; if Mario avoids it, then another fighter will have eaten it when you get back from your match. It's also heavily implied [[spoiler:Rawk Hawk]] did the same to previous champion Prince Mush prior to their match.
* In the online game ''Receptionist's Revenge'', you play as a disgruntled receptionist getting back at your lazy boss by putting disgusting things in his coffee while he flirts with the hot secretary. If you make it to the end of the game without getting caught, you're rewarded with a "you win" screen that shows your boss throwing up in the toilet.
* A bizarre example occurs in ''VideoGame/SamAndMaxBeyondTimeAndSpace - Night of the Raving Dead'': Max, knowing that he will be bitten by a vampire, drinks holy water beforehand, thereby spiking his own blood with vampire poison.
* In ''VideoGame/ShinMegamiTenseiStrangeJourney'', you can do this to a boss. Specifically, Horkos periodically summons a Katakirauwa and then eats it a few turns later to recover his HP. However, if you inflict status ailments on the Katakirauwa, and then Horkos eats the afflicted demon, Horkos will contract that same status ailment.
* In ''VideoGame/StyxMasterOfShadows'' and ''VideoGame/StyxShardsOfDarkness'', Styx can poison food or water/wine with his bile, which will kill wandering guards just a few seconds after they consume it.
* In ''VideoGame/{{Technomage}}'', the player is required to pull a non-lethal variant in one of the early stages. An essential item is stored in a warehouse, which is blocked off by a guard. The trick is to gain some castor oil from another person in the town, and then go to the inn where the guard’s favourite stew is being prepared. They then pour some of the oil into the stew and then receive a batch from the inattentive chef. They go back to the guard and give him the stew, which makes him sick, so he heads to the nearby hospital, leaving the warehouse wide open.
* ''VideoGame/YandereSimulator'': A high biology grade lets Yandere-chan identify poisons which she can swipe and slip into a student's lunch. This allows her to [[MurderTheHypotenuse eliminate rivals]] without drawing suspicion upon herself. However, if Senpai witnesses the death, particularly if the rival is his childhood friend or sister, his sanity will take a huge hit. She can also slip an emetic poison into either the rival's lunch to make her sick and get her alone to murder her out of Senpai's sight or into ''Senpai's'' lunch to make ''him'' sick and sabotage his budding relationship with the rival. There's also the option of poisoning other people's lunches with the above two and sedatives to get rid of witnesses or something to induce a headache, which will distract the nurse enough for Yan-chan to steal tranquilizer. In [[{{Prequel}} 1980s Mode]] [[spoiler:this trope plays a role in two of the 'canon' elimination methods for rivals: Sumiko dies from eating poisoned food, and Ritsuko's food is laced with a sedative which puts her to sleep and leaves her unable to stop Ryoba when Ryoba pushes her into the pool, causing her to drown.]]

[[folder:Visual Novels]]
* ''Franchise/AceAttorney'':
** In ''VisualNovel/PhoenixWrightAceAttorneyTrialsAndTribulations'', [[spoiler:Furio Tigre]] poisons Glen Elg by slipping poison into his coffee, inadvertently duplicating the actions of [[spoiler:Dahlia Hawthorne's near-murder of Diego Armando several years earlier]].
** Subverted in ''VisualNovel/ApolloJusticeAceAttorney'': It looks like [[spoiler: Vera Misham [[SelfMadeOrphan killed her father Drew]] by putting poison in his coffee]]... but in reality, [[spoiler: ''Kristoph Gavin'' poisoned a stamp that Drew licked few minutes before having the supposedly fatal drink]]. And later [[spoiler: he poisons Vera herself--but rather than lacing her food with anything, he uses ''her nail polish'', knowing that she has the habit of biting her nails when nervous.]]
** ''VisualNovel/TheGreatAceAttorney: Adventures'':
*** [[spoiler:Jezaille]] poisons [[spoiler:Wilson]]'s drink. [[spoiler: In the next game, [[LaserGuidedKarma her own drink gets poisoned]].]]
*** The [[spoiler:Burya's crew drugs the food to the passengers]].
* ''VisualNovel/DaughterForDessert'':
** The protagonist butters Mortelli’s toast with raw chicken grease in order to put him out of action so he could break into the detective’s office. His plan works; Mortelli has to run to the bathroom for a while.
** Nor is this the first time he does something like this. [[spoiler:In a flashback, we see him putting laxatives in the water cooler in the office of Lainie’s family’s lawyer so he has time to hack into the man’s computer.]]
* Played with in the Onikakushi-ken arc of ''VisualNovel/HigurashiWhenTheyCry''. Rena and Mion visit Keiichi and give him a box of ohagi as part of a club activity. However, upon biting into one of them Keiichi discovers a needle, convincing him that Rena and Mion are out to get him. It's later revealed that [[spoiler:Keiichi was delusional and hallucinated that there was a needle in the ohagi when Mion had actually put tabasco sauce in the ohagi as a prank]].
* In ''VisualNovel/LongLiveTheQueen'', Elodie may be sent poisoned chocolates and die from eating them if she lacks the skills required to realize that there's something suspicious about them.
[[/folder]]

[[folder:Web Animation]]
* ''WebAnimation/GossipCity'': Keigo mixes paint in his pregnant wife Himari's food as a prank for her inability to do the chores. Thankfully, nothing happened to the baby, but Sumomo returns him the favor by spiking his cream stew with expired kalpiko.
[[/folder]]

[[folder:Webcomics]]
* In ''Webcomic/DrowTales'', the BigBad, Snadhya'rune, uses a PoisonAndCureGambit to threaten all the ruling clans, distributing vials of madness-inducing flower pollen among the population. This leads to multiple traitors poisoning their clans' meals for their own purposes.
* ''Webcomic/GirlGenius'': Venthraxus Heterodyne's favorite cook went mad and ended up poisoning everything he made [[http://www.girlgeniusonline.com/comic.php?date=20080314 later on in life]]:
-->'''Moloch:''' Oh, they haven't found the ''master kitchen'' yet. This one was built for Venthraxus Heterodyne's favorite cook. He was a real artist, but one day he went around the been and started ''poisoning'' everything. Thought he was the reincarnation of some Borgia or something. The Heterodyne thought he was funny, so he built him this place and locked him in. So the old guy was happy for ''years'' until he accidentally ate his own cooking.
[[/folder]]

* In the ''WebAnimation/BestFiends'' web short "The Immortal Cockroach", one of the attempts to off Lapoleon is a plate of poisoned fruit. The fruit itself is obviously wrong, coated in an obvious cloud of green poison, but Lapoleon, being a [[NighInvulnerable cockroach]], eats it no problem and ''belches out'' the poison. The Slug that was attempting to poison him is dumbfounded, and eats a remaining single cherry to see how he failed, only to immediately keel over.
* ''Wiki/SCPFoundation'': The Foundation has been known to dose witnesses of [=SCPs=] with amnesiac drugs, or even just conventional psychedelics, and occasionally their own agents too. The presenter at their UsefulNotes/{{Memetics}} and Infohazards Division [[http://www.scpwiki.com/memetics-and-infohazards-division-orientation orientation session]] is very open about the hallucinogens in the food there and assures them [[GoMadFromTheRevelation they'll need it.]]
* Parodied in ''WebVideo/ScottTheWoz'':
** In "Homecoming", after Scott decided he wants his homecoming party to allow alcohol and drugs, he starts to deliberately spike all the food and drinks. Cue Scott filling the punch bowl with cigarettes, putting a beer can between two halves of a slider sandwich, [[TheLastOfTheseIsNotLikeTheOthers and pouring beer into the homecoming ballot box]].
** Also shown in "It's A Bargain Bin Christmas"; some of Scott's guests for the gala are vegan, [[ComicallyMissingThePoint so Scott laced all the meat dishes with tofu]].

*** [[spoiler:Jezaille]] poisons [[spoiler:Wilson]]'s drink.

* Early in ''Film/{{Kate}}'' the protagonist is poisoned when her date spikes her drink.

* Downplayed and subverted in ''Film/ChildrensPartyAtThePalace''. The Grand High Witch planned to put her potion in the [[UsefulNotes/HMTheQueen Queen]]'s cake that would [[BalefulPolymorph turn whoever eats from it into mice]], until she finds out there was no cake to begin with. Eventually the villains bake their own cake with her potion in it...but turns out the potion had no effect on the Goodies.

* In ''VideoGame/KingsQuestIIIToHeirIsHuman'', you defeat Manannan by hiding a crumbled magical cookie in his porridge. When the unsuspecting wizard eats the porridge, the cookie [[BalefulPolymorph turns him into a cat]].

** Gus Fring takes out [[spoiler: Don Eladio, his clan and the remaining member of the Salamanca family (aside from Hector) with a poisoned bottle of Zafiro Añejo. Gus Fring drinks the tequila as well to avoid suspicions and vomits it up later, but has to be hospitalised for its lingering effects.]]

** [[spoiler:Hisamichi]] slipped poison into the food and drink of Yoshimune's older sisters and the closest rival to the throne to ensure that Yoshimune got the shogunate. She has to clarify that she did ''not'' do that to Ietsugu, as Ietsugu was an IllGirl and not expected to make it to adulthood.

* In ''Literature/BattleRoyale'', Yuko Sakai, mistakenly believing Shuya Nanahara killed another classmate in an altercation (the death was actually accidental), attempts to poison Shuya's meal with potassium chloride while he's recovering at a lighthouse where she and her friends are holed up. Another friend eats the meal instead, her subsequent death causing a chain reaction that leads to all of Yuko's friends [[MexicanStandoff shooting and killing each other]] and Yuko, herself, to be DrivenToSuicide.

** ''Testament'' opens with the protagonist noticing that his cat has dropped dead after drinking from its bowl. He suddenly realises the milk has been poisoned (this was when milk was delivered to your door in bottles) but is too late to stop his wife from feeding their baby son from his baby bottle. Things don't improve from there as his family is being targetted by a right wing terrorist organisation.

*** "[[Recap/StarTrekDeepSpaceNineS01E05Babel Babel]]" has a [[YourTerroristsAreOurFreedomFighters terrorist]] device that spikes the food and drink replicators with an aphasia virus that ends up never being dispersed because the virologist who planted it got captured. O'Brien accidentally trips the device while making repairs, and it eventually becomes aerosolized.

* ''Literature/AndThenITurnedIntoAMermaid'': After Molly's falling-out with Ada, Molly's sister Margot puts cayenne pepper in Ada's ketchup, knowing how much she hates spicy food.

* The romance novel ''Whisper to Me of Love'' has a young woman's maid placing poison in her milk. Poison that she thinks is an antidote to a drug supposedly being given to her by her lover to trick her into a relationship with him (she has been told all this by the novel's villain, who wants to kill the heroine in order to claim her inheritance). What saves her life is the arrival of the hero, just after she's poured some milk out into a saucer for the cat. As the two sit and chat, he is horrified to see that the cat has died after drinking the tainted milk.