History Main / MegaMicrobes

* In ''Film/FantasticVoyage'', the heros had to survive being caught in the crossfire of antibodies versus bacteria, "recticular fibers" that clog the intake ports, an direct attack on Grant and Cora by antibodies, and white corpuscles.

* In one episode of ''WesternAnimation/CaptainNTheGameMaster'' Kevin gets sick and the source of the disease is microbe called Viroid. In response to this the N Team shrinks down to confront him inside Kevin's body

* ''X Multiply'' is an old shmup by Irem, similar to their flagship series ''VideoGame/RType'', where an experimental ship gets shrunk and injected into a human body to destroy the diseases from within. Said diseases look like the cyber-organic foes from ''R-Type'', complete with a BattleshipRaid against some huge multi-part monstrosity.

** ''ComicBook/DisneyDucksComicUniverse'': In the Creator/DonRosa Scrooge [=McDuck=] story "The Incredible Shrinking Tightwad", Scrooge and Donald are eventually shrunk down to microscopic size due to the effects of a malfunctioning shrinking ray, and are menaced by a horde of microbes.

** An episode of ''Series/StarTrekVoyager'' has the crew dealing with [[ArtisticLicenseBiology Giant Basketball-sized flying viruses]].

* The protagonist of ''Manga/{{Moyashimon}}'' has the ability to perceive and interact with microbes as if they were macroscopic and sapient creatures.

* In the Creator/DonRosa [[ComicBook/DisneyDucksComicUniverse Scrooge McDuck]] story "The Incredible Shrinking Tightwad", Scrooge and Donald are eventually shrunk down to microscopic size due to the effects of a malfunctioning shrinking ray, and are menaced by a horde of microbes.
* In a ''[[WesternAnimation/{{Goofy}} Super Goof]]'' story, a villain used a ray gun to enlarge animals. In the final battle, Super Goof was pitted against a van-sized amoeba.
* One old horror comic dealt with an alien seeking the most ferocious creature on Earth but as he probes the human protagonist's mind he finds everything offered up (like bears and tigers) to be quite boring, until he picks up on a subconscious thought from the protagonist and teleports them where a truly horrific tentacled beast awaits that the alien quickly photographs then kills. The monster? It was the CANCER infecting his terminally ill wife, only now she's cured.
* An old Silver Age Superman story dealt with a sheltered bubble boy who believed a futuristic version of the Fugitive on TV was real after seeing that Superman was real and deciding that his parents had lied and that everything on TV was real so escapes to warn the TV character being hunted that the future cop's about to capture him. He tries to trick the kid into killing the other actor to save his career only to end up consumed by one of the kid's white blood cells, as his parents never informed him that exposing his blood to air caused them to grow to blob monster size and he'd scratched himself on a bush earlier.

* ''Film/{{Evolution}}'' used a giant microbe. Technically, it's an amoeba...
* The B-Movie ''The Flesh Eaters'' features the titular micro-organisms joining together to become one large creature.

* In some ''Literature/ChooseYourOwnAdventure'' books that involve some shrink-ray device, a few bad endings have microbes (e.g. paramecium, or white blood cells) attach themselves to an object which returns to normal size. In the case of an amoeba, it took Kentucky for breakfast, then [[ArtisticLicenseGeography Louisiana]] for lunch. Even at their normal microscopic size, they look very large.

* There's a ''TabletopGame/YuGiOh'' card called [[http://yugioh.wikia.com/wiki/Giant_Germ Giant Germ]] that deals damage and acts like an AsteroidsMonster.

* The protagonist of ''Manga/{{Moyashimon}} has the ability to perceive and interact with microbes as if they were macroscopic and sapient creatures.

* ''Franchise/{{Bionicle}}'': While hunting for the Mask of Life, the Toa Inika encounter some strange monsters that self duplicate when struck and figure out that they are actually enlarged microbes.

* One of the monsters of the week in WesternAnimation/StaticShock is a bacterium enlarged into a massive BlobMonster by bang baby gas.

[[folder:Card Games]]
* Phyrexian Living Weapons in ''TabletopGame/MagicTheGathering'' come into play automatically attached to a 0/0 Germ token. The germ can't survive on its own outside of the weapon, but with a few buffs to its toughness and power it's possible to beat things up with a giant Germ. Though these "germs" aren't as much microbes as baseline phyrexian life forms.
[[/folder]]

[[CaptainObvious Diseases are scary.]] However germs are rather small. This leads to a bit of a problem. You see, scary things can make good villains, but you need to be able to ''[[RuleOfPerception see them]]''.

This has led to writers coming up with two different but functionally similar solutions to this problem. Either have the microbe get really really big or have the hero get really really small. This runs almost entirely on YouFailBiologyForever and the most extreme form of SquareCubeLaw.

* In some ''Literature/ChooseYourOwnAdventure'' books that involve some shrink-ray device, a few bad endings have microbes (e.g. paramecium, or white blood cells) attach themselves to an object which returns to normal size. In the case of an amoeba, it took Kentucky for breakfast, then [[YouFailGeographyForever Louisiana]] for lunch. Even at their normal microscopic size, they look very large.

** An episode of ''Series/StarTrekVoyager'' has the crew dealing with [[YouFailBiologyForever Giant Basketball-sized flying viruses]].

* In ''Literature/{{Illuminatus}}'', the massive sentient one-celled creature Leviathan is beleived to have been inspired by the [[http://en.wikipedia.org/wiki/Xenophyophore xenophyophores]] discussed in Real Life, below. Creatror/RobertAntonWilson and Robert Shea realised an amoeba is practically immortal - if it evades diseases and predators it has no reason or need to die - and wondered what would happen if one grew rather than divided. Over ''millenia''.

* Phyrexian Living Weapons in ''TabletopGame/MagicTheGathering'' come into play automatically attached to a 0/0 Germ token. The germ can't survive on its own outside of the weapon, but with a few buffs to its toughness and power it's possible to beat things up with a giant Germ.

* "Webcomic/Unity" has, in the [[https://beesbuzz.biz/comics/unity/invasion/ Invasion story arc]], a number of sentient single-celled organisms which the colonists end up calling "macrobes."

* In ''VideoGame/{{Pikmin}}'', one of the creatures Captain Olimar can encounter is a Goolix. Its a giant unicellular organism at least a foot across (gigantic compared to the tiny Olimar) with a watery interior and two nuclei.

* In ''VideoGame/{{Pikmin}}'', one of the creatures Captain Olimar can encounter is a giant unicellular organism at least a foot across (gigantic compared to the tiny Olimar) with a watery interior and two nuclei.

* Toys/GiantMicrobes [[http://www.giantmicrobes.com/ toys]] are this trope (in plush form) and are the former TropeNamer. However not all are infectious microbes. One is yeast, a few are cells.