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** In "[[Recap/BatmanBeyondS2E8HookedUp Hooked Up]]", total-immersion virtual reality (basically computer-generated euphoric hallucinations) is portrayed as being very addictive, with catastrophic side effects inevitably resulting from prolonged use.

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** In "[[Recap/BatmanBeyondS2E8HookedUp Hooked Up]]", total-immersion virtual reality (basically computer-generated euphoric hallucinations) is portrayed as being potentially addictive. Spellbinder creates an even more potent version that is ''designed'' to be very addictive, addictive because it also stimulates the subject's emotional need for love and affection, with catastrophic side effects inevitably resulting from prolonged use.use.
** In "[[Recap/BatmanBeyondS2E12Babel Babel]]", Shriek creates "the fork"; a small, handheld device that can emit soundwaves that directly stimulate the brain's pleasure centers. Whilst this mechanically falls under ElectricInstantGratification, the effects are depicted as very much akin to a drug addiction -- Shriek's assistant Ollie becomes a giggling, useless idiot whilst playing with the fork, and he's so hooked on it that he happily helps Shriek in his plans in exchange for being allowed to use it.

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* DirtyOIdMan Happosai in ''Manga/RanmaOneHalf'' is so committed to lechery that the act of indulging in his perversions -- groping women and playing with women's underwear -- is physically necessary for him. He can literally replenish his depleted stamina by nuzzling a woman's breasts or rubbing a brassier or a set of panties, and if he goes too long without indulging, he rapidly gets weaker, to the point that people believe ''in-universe'' that he'd '''die''' if he spent too long without being perverted. He's even been outright described as addicted to his chosen perversions. Protagonist Ranma Saotome readily exploits his need for lecherous contact with women's bodies, as well as the corresponding fact that [[WeaksauceWeakness contact with men's underwear weakens Happosai]].



* ''ComicBook/ElfQuest'' has "dreamberries". In the Russian version, they're called "Drunkberries".

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* ''ComicBook/ElfQuest'' has "dreamberries"."dreamberries", a fantastic equivalent to grapes that are eaten when fermented for their mildly intoxicating effects -- they can also can be fermented into a primitive but far more potent liquor. In the Russian version, they're called "Drunkberries".



** There is a drug that gives immortality to humans, made by killing and harvesting glands of a sapient alien race, the Stookies, that have heart attacks at the slightest things (similar to fainting goats). Naturally, stookie glanding is completely illegal and people who deal in it are dealt with in Dredd's normal manner (most of them wind up dead). So do most of the Stookies he's trying to save. Stookie glands are so addictive, that the symptoms of coming off them involves rapid ageing.

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** There is a The drug Stookie can physically undo the effects of aging and prolong life to the point of virtual immortality. The problem is that gives immortality to humans, it's made by killing and harvesting glands of a sapient alien race, the Stookies, that have heart attacks at the slightest things (similar to fainting goats). Naturally, stookie glanding is completely illegal and people who deal in it are dealt with in Dredd's normal manner (most of them wind up dead). So do most of the Stookies he's trying to save. It's unclear if Stookie glands is innately addictive in its own right, or if users might as well be addicted because they revert to their actual age ''extremely'' quickly once the drug wears off, which mostusers are so addictive, that the symptoms of coming off them involves rapid ageing.understran

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* In ''Literature/TheDarkProfitsSaga'', healing potions are a fantastic drug that's essential for adventurers...and also highly addictive. They do exactly what they claim to do, which is heal wounds, but they also provide a general sense of "feeling good" as wounds are healed, resulting in some people becoming "healing junkies", desperate to get their next healing potion, and willing to hurt themselves, sometimes badly, so that it works that much better. [[spoiler: Kaitha]] is one such addict, and the narrative doesn't have to go far to show how dangerous the addiction is to everyone around [[spoiler: her]].

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* In ''Literature/TheDarkProfitsSaga'', healing potions are a fantastic drug that's essential for adventurers...and also highly addictive. They do exactly what they claim to do, which is heal wounds, but they also provide a general sense of "feeling good" as wounds are healed, resulting in some people becoming "healing junkies", desperate to get their next healing potion, and willing to hurt themselves, sometimes badly, so that it works that much better. [[spoiler: Kaitha]] [[spoiler:Kaitha]] is one such addict, and the narrative doesn't have to go far to show how dangerous the addiction is to everyone around [[spoiler: her]].[[spoiler:her]].



** The "[=ThreeEye=]" in ''Literature/{{Storm Front|DresdenFiles}}'' is supposed to give its users second sight. Harry is skeptical [[spoiler:until a junkie notices a rather nasty psychic scar of his. It turns out that it actually ''does'' work; it's a potion mass-produced by an EvilSorcerer after he realized that it was addictive]]. Harry also notes that regardless of any other circumstances, the drug will result in insanity more often than not, as [[spoiler: anything seen with Second Sight can ''never'' be forgotten. Wizards are trained on how to handle that. Mundanes are not.]]

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** The "[=ThreeEye=]" in ''Literature/{{Storm Front|DresdenFiles}}'' is supposed to give its users second sight. Harry is skeptical [[spoiler:until a junkie notices a rather nasty psychic scar of his. It turns out that it actually ''does'' work; it's a potion mass-produced by an EvilSorcerer after he realized that it was addictive]]. Harry also notes that regardless of any other circumstances, the drug will result in insanity more often than not, as [[spoiler: anything [[spoiler:anything seen with Second Sight can ''never'' be forgotten. Wizards are trained on how to handle that. Mundanes are not.]]not]].



** ''Series/LegendsOfTomorrow'': During the back half of Season 6, Constantine compensates for the loss of his inherent magic earlier in the season by drinking vampire blood to give himself a boost. This quickly becomes a metaphor for drug use, as he's manic and unpredictable when on it and sickly and irritable when in withdrawal, and the plot line culminates with Zari threatening to leave him if he doesn't sober up, which he attempts by going cold turkey. [[spoiler: Unfortunately, the nature of the addiction causes him to develop an EnemyWithin manifesting his darker impulses, which eventually [[SplitPersonalityTakeover takes over]] during the final episodes of the season.]]

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** ''Series/LegendsOfTomorrow'': During the back half of Season 6, Constantine compensates for the loss of his inherent magic earlier in the season by drinking vampire blood to give himself a boost. This quickly becomes a metaphor for drug use, as he's manic and unpredictable when on it and sickly and irritable when in withdrawal, and the plot line culminates with Zari threatening to leave him if he doesn't sober up, which he attempts by going cold turkey. [[spoiler: Unfortunately, [[spoiler:Unfortunately, the nature of the addiction causes him to develop an EnemyWithin manifesting his darker impulses, which eventually [[SplitPersonalityTakeover takes over]] during the final episodes of the season.]]



* In ''Series/TorchwoodChildrenOfEarth'', the alien species named the 456 return to Earth (after abducting 12 children back in 1965) and demands 10% of the children of the world, [[spoiler: as the children's bodies create chemicals that act as narcotics for them to "feel good" as they did with one of the children from 1965 (who is now a [[BodyHorror shrivelled husk that has never aged for 40 years]] but [[AndIMustScream still conscious]])]].

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* In ''Series/TorchwoodChildrenOfEarth'', the alien species named the 456 return to Earth (after abducting 12 children back in 1965) and demands 10% of the children of the world, [[spoiler: as [[spoiler:as the children's bodies create chemicals that act as narcotics for them to "feel good" as they did with one of the children from 1965 (who is now a [[BodyHorror shrivelled husk that has never aged for 40 years]] but [[AndIMustScream still conscious]])]].



** ''VideoGame/BatmanArkhamOrigins'' introduces TN-1, the precursor to Titan, which causes brain damage (primarily to the memory centers of the mind) as a side-effect. This is used to {{Retcon}} Bane's appearance in ''Asylum'' and ''City''; in ''Origins'' he's similar to his comics counterpart (a GeniusBruiser who's larger than normal men but not ''too'' unrealistic), but after taking TN-1, he turns into a walking mountain of muscle and seems to lose some brainpower in the process. [[spoiler: It also causes him to forget that he'd figured out Batman's secret identity, which was a plot point in ''Origins'' but was never acknowledged in ''Asylum'' or ''City'']].

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** ''VideoGame/BatmanArkhamOrigins'' introduces TN-1, the precursor to Titan, which causes brain damage (primarily to the memory centers of the mind) as a side-effect. This is used to {{Retcon}} Bane's appearance in ''Asylum'' and ''City''; in ''Origins'' he's similar to his comics counterpart (a GeniusBruiser who's larger than normal men but not ''too'' unrealistic), but after taking TN-1, he turns into a walking mountain of muscle and seems to lose some brainpower in the process. [[spoiler: It [[spoiler:It also causes him to forget that he'd figured out Batman's secret identity, which was a plot point in ''Origins'' but was never acknowledged in ''Asylum'' or ''City'']].''City''.]]



* ''VideoGame/CrueltySquad'':
** Whatever the hell the police chief in Androgen Assault has been smoking, the mission briefing blames it for his current state of mind. It turns out that it's his [[BodyHorror state of body]] that's the more relevant problem, given that he is now a psychopathic, ranting zombie blown into something resembling a bouncy castle of flesh who spits acid at people.
** There's an implication that Biocurrency can serve as this, as your very first target is more interested in screaming about investing in Biocurrencies, becoming God, "vomiting blood all over his office", and has a ''noticeably'' deformed face.
** The yuppies in Neuron Activator regularly talk about ingesting Gore, some kind of party drug that overclocks your biological processes. Side effects include [[LudicrousGibs exploding into agonized meat]].



* ''VideoGame/FallenLondon'' has "prisoner's honey" which transports you physically into a DreamLand. It's regulated, but legal. But stay away from red honey, which is one of the few things that's outright illegal in Fallen London. [[spoiler: Red honey lets you [[MindRape enter somebody else's memories and mess around]]. And then there's Cardinal's Honey, which thrusts you into dreams of the dead; this is such a massive backfire it's used as an especially awful poison more than a drug]].
** One subplot in ''VideoGame/SunlessSea'' involves [[spoiler: sphinxstone]], which turns out to be this for [[GeniusLoci Genii Locorum]], or at least for [[spoiler: the Bazaar]]. Also, for Neathers, sunlight is a dangerously addictive experience that produces feelings of euphoria even as [[WeakenedByTheLight you burn to ashes]]. Smugglers visit the surface with special mirror-lined boxes to bring it back to the Neath.

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* ''VideoGame/FallenLondon'' has "prisoner's honey" which transports you physically into a DreamLand. It's regulated, but legal. But stay away from red honey, which is one of the few things that's outright illegal in Fallen London. [[spoiler: Red [[spoiler:Red honey lets you [[MindRape enter somebody else's memories and mess around]]. And then there's Cardinal's Honey, which thrusts you into dreams of the dead; this is such a massive backfire it's used as an especially awful poison more than a drug]].
drug.]]
** One subplot in ''VideoGame/SunlessSea'' involves [[spoiler: sphinxstone]], [[spoiler:sphinxstone]], which turns out to be this for [[GeniusLoci Genii Locorum]], or at least for [[spoiler: the [[spoiler:the Bazaar]]. Also, for Neathers, sunlight is a dangerously addictive experience that produces feelings of euphoria even as [[WeakenedByTheLight you burn to ashes]]. Smugglers visit the surface with special mirror-lined boxes to bring it back to the Neath.



* Dream Leaf in ''VideoGame/GoldenSunDarkDawn'' is an iridescent tree leaf from a semi-sentient (?) tree that acts as a sedative and gives the user good dreams. It is typically used is by old people and insomniacs. In war-torn Border Town, it is taken recreationally by those who want to dream of the good old days [[spoiler: or by our heroes, [[GuideDangIt to access the Haures summon in the blocked-off part of town]]]]. When the Dream Tree is under attack by the ghostly monster Sludge, its leaves instead induce nightmares.

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* Dream Leaf in ''VideoGame/GoldenSunDarkDawn'' is an iridescent tree leaf from a semi-sentient (?) tree that acts as a sedative and gives the user good dreams. It is typically used is by old people and insomniacs. In war-torn Border Town, it is taken recreationally by those who want to dream of the good old days [[spoiler: or [[spoiler:or by our heroes, [[GuideDangIt to access the Haures summon in the blocked-off part of town]]]]. When the Dream Tree is under attack by the ghostly monster Sludge, its leaves instead induce nightmares.



* The city of Billion in ''VideoGame/{{Gungrave}}'' is overrun with crime and a mysterious drug known only as "seed". It's highly addictive and gives the user increased resilience and strength, along with lowered inhibitions and euphoria. However, it eventually drives the user insane and leads to death. Turns out that seed is really [[spoiler: derived from a malevolent race of alien parasites whose [[AlwaysChaoticEvil only reason to live is to reproduce by taking control of other lifeforms]]]]. And it's used in the technology that brought the protagonist back from death and nearly all the enemies he fights throughout the series.

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* The city of Billion in ''VideoGame/{{Gungrave}}'' is overrun with crime and a mysterious drug known only as "seed". It's highly addictive and gives the user increased resilience and strength, along with lowered inhibitions and euphoria. However, it eventually drives the user insane and leads to death. Turns out that seed is really [[spoiler: derived [[spoiler:derived from a malevolent race of alien parasites whose [[AlwaysChaoticEvil only reason to live is to reproduce by taking control of other lifeforms]]]]. And it's used in the technology that brought the protagonist back from death and nearly all the enemies he fights throughout the series.



* ''VideoGame/StyxMasterOfShadows'' has processed amber, with amber being the liquid sap of the world tree and double as {{Mana}} for Styx to use his various abilities. Though officially prohibited, amber was seen widely traded and smuggled in various parts of Akenash, providing a justified source of bottles of amber lying about or being carried around for Styx to steal. The sequel, ''VideoGame/StyxShardsOfDarkness'' reveals that [[spoiler: after the Fall of Akenash, the primary source of Amber is the Dark Elves, who juice goblins to get their fix!]]

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* ''VideoGame/StyxMasterOfShadows'' has processed amber, with amber being the liquid sap of the world tree and double as {{Mana}} for Styx to use his various abilities. Though officially prohibited, amber was seen widely traded and smuggled in various parts of Akenash, providing a justified source of bottles of amber lying about or being carried around for Styx to steal. The sequel, ''VideoGame/StyxShardsOfDarkness'' reveals that [[spoiler: after [[spoiler:after the Fall of Akenash, the primary source of Amber is the Dark Elves, who juice goblins to get their fix!]]fix]]!



* In ''WesternAnimation/TheSpectacularSpiderMan'', the series pays homage to the storyline about Harry Osborn's drug addiction in [[ComicBook/SpiderMan the comics]] by using the PsychoSerum "Globulin Green". This has the fortunate side-effect of merging two of Harry's biggest storylines, his drug addiction and his eventual becoming of the Green Goblin. This is alluded to in the series, as [[spoiler: he is originally thought to be the Green Goblin before it's revealed Norman's been manipulating Harry into taking the fall for him. Besides making the Harry story tighter it also makes the reveal of Norman Osborn being the Green Goblin a genuine shock for the first time in over forty years!]]

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* In ''WesternAnimation/TheSpectacularSpiderMan'', the series pays homage to the storyline about Harry Osborn's drug addiction in [[ComicBook/SpiderMan the comics]] by using the PsychoSerum "Globulin Green". This has the fortunate side-effect of merging two of Harry's biggest storylines, his drug addiction and his eventual becoming of the Green Goblin. This is alluded to in the series, as [[spoiler: he [[spoiler:he is originally thought to be the Green Goblin before it's revealed Norman's been manipulating Harry into taking the fall for him. Besides making the Harry story tighter it also makes the reveal of Norman Osborn being the Green Goblin a genuine shock for the first time in over forty years!]]years]]!

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* ''Literature/TheHanSoloTrilogy'': Spice, which has various types and is highly restricted, thus also very profitable for smuggling. There's the Exultation as well, which isn't an actual substance but in fact the mating call male t'landa Til use with a drug-like effect on members of other species. It is equally addictive, though, and used to hook "pilgrims" in their fake religion on Ylesia.

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* ''Literature/TheHanSoloTrilogy'': ''Literature/TheHanSoloTrilogy'':
**
Spice, which has various types and is highly restricted, thus also very profitable for smuggling. Glitterstim, the most powerful kind, can give a user {{telepathy}} temporarily as well.
**
There's the Exultation as well, which isn't an actual substance but in fact the mating call male t'landa Til use with a drug-like effect on members of other species. It is equally addictive, addictive though, and used to hook "pilgrims" in their fake religion on Ylesia.
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* ''Literature/EmpireOfTheVampire'': '''Sanctus''' is a powder made from extracted [[ThePowerOfBlood vampire blood]], smoked through a pipe by the Silversaints in order to slake [[HorrorHunger their own thirst for human blood]] and boost their own powers before going into battle. Vampiric blood itself is highly addictive and repeated consumption renders one enthralled to the undead from which it came. To avoid this, and dull its potency in general, the blood is distilled and powdered, and only smoked once a day at most, usually during evening mass. Even so, ''sanctus'' is incredibly potent and almost as addictive, with the highs it provides to the ''palebloods'' unlike any other sensual experience, and sooner of later, all Silversaints will wind up completely dependant upon it.
-->'''Gabriel de León:''' “There’s an art to smoking sanctus. Hold the flame too close, the blood will burn. Hold it too far, it’ll melt too slow, liquefying rather than vaporizing. But get it right… God Almighty, get it right, and it’s magik. A bright red bliss, filling every inch of your sky... Words can’t describe it. You might as well try to explain a rainbow to a blind man. Imagine the moment, that first second you slip between a lover’s thighs. After an hour or more of worship at the altar, when everything else has run its course and there’s naught but want for you in her eyes and finally she whispers that magic word … please... Take that heaven and multiply it a hundredfold. You might be close.”
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* ''Westernanimation/Phantom2040'': Dimulations of the natural environment from before the Resource Wars are portrayed like addictive drugs, complete with strung-out junkies going without food for a hit, and getting violent when their session is interrupted.

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* ''Westernanimation/Phantom2040'': Dimulations Simulations of the natural environment from before the Resource Wars are portrayed like addictive drugs, complete with strung-out junkies going without food for a hit, and getting violent when their session is interrupted.

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* ''Literature/TheInfernalDevices'': Yin Fen is a highly-addictive stimulant and poison. It provides a feeling of exhilaration and ecstasy, but slowly kills its user and leaches the color from their body.


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* ''Franchise/TheShadowhunterChronicles'': Yin Fen is a highly-addictive stimulant and poison. It provides a feeling of exhilaration and ecstasy, but slowly kills its user and leaches the color from their body. A major character in ''Literature/TheInfernalDevices'', Jem Carstairs, is [[ForcedAddiction unwillingly made reliant]] on the drug, which causes him to grow weak and sickly.
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* ''Literature/TheInfernalDevices'': Yin Fen is a highly-addictive stimulant and poison. It provides a feeling of exhilaration and ecstasy, but slowly kills its user and leaches the color from their body.

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* ''Series/KamenRiderW'' has the Gaia Memories, specialized items forged from the world's internal data which people use to become [[MonsterOfTheWeek Dopant]] and are distributed by criminals around the city of Futo. While not directly compared to drugs, the series makes many very unsubtle allusions to them being such, with the Dopants MeaningfulName being in part the word "doping", one villain expressing outrage when he hears they are being distributed to children, them being directly injected into the body via a marked spot on their body given by a dealer, possessing addictive qualities, and gradually rendering the users personalities violently unstable over time, eventually either killing or severely injuring them after their bodies are unable to sustain their developing powers. Notably, while both the heroes and villains also use them to battle, as is tradition in ''Rider'', this involves the use of equipment specifically designed to harness the power safely.
* ''Series/KamenRiderFourze'' follows up the above example with the Astro Switches used by [[MonsterOfTheWeek Zodiarts]]. Like Gaia Memories, the Switches are distributed to high schoolers by the villains, and their use is shown to result in addiction and insanity. In one episode, a previous Astro Switch user is shown having withdrawal symptoms, refusing to go to school out of fear of receiving another Switch and having a relapse.

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* Franchise/KamenRider:
**
''Series/KamenRiderW'' has the Gaia Memories, specialized items forged from the world's internal data which people use to become [[MonsterOfTheWeek Dopant]] and are distributed by criminals around the city of Futo. While not directly compared to drugs, the series makes many very unsubtle allusions to them being such, with the Dopants MeaningfulName being in part the word "doping", one villain expressing outrage when he hears they are being distributed to children, them being directly injected into the body via a marked spot on their body given by a dealer, possessing addictive qualities, and gradually rendering the users personalities violently unstable over time, eventually either killing or severely injuring them after their bodies are unable to sustain their developing powers. Notably, while both the heroes and villains also use them to battle, as is tradition in ''Rider'', this involves the use of equipment specifically designed to harness the power safely.
* ''Series/KamenRiderFourze'' follows up the above example with the ** ''Series/KamenRiderFourze'': The Astro Switches used by [[MonsterOfTheWeek Zodiarts]]. Like Gaia Memories, the Switches are distributed to high schoolers by the villains, and their use is shown to result in addiction and insanity. In one episode, a previous Astro Switch user is shown having withdrawal symptoms, refusing to go to school out of fear of receiving another Switch and having a relapse.
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* ''Manga/AfterGod'': Vollof has become addicted to some substance Alula made for him and can only think about getting more. Orokapi's venom helps with the withdrawal symptoms. It's so bad, when Alula asks between Orokapi and drugs, Vollof shamelessly picks drugs.

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* ''Literature/RedDwarf'' has "Bliss", a brown powder that literally makes the user believe that they're God, can supposedly get someone hooked just by looking at it, and causes the user to become suicidally depressed for decades after coming down, which is probably what makes it so addictive. There's also Better than Life, which is a sort of LotusEaterMachine in the books rather than the more innocuous artificial reality video game of [[Series/RedDwarf the TV series]].

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* ''Literature/RedDwarf'' has ''Literature/RedDwarf'':
**
"Bliss", a brown powder that literally makes the user believe that they're God, God. The high from taking Bliss lasts only 15 minutes and is followed by 25 years of suicidal depression, causing most users to become addicted immediately. It can also supposedly get someone hooked just by looking at it, and causes the user to become suicidally depressed for decades after coming down, it.
** The [[InsideAComputerSystem Total Immersion Videogame]] ''Better than Life'',
which is probably what makes it so addictive. There's also Better than Life, which is a sort of LotusEaterMachine in gives the books rather than player [[YourHeartsDesire their heart's deepest desires]]. Unlike the more innocuous artificial reality video game of version from [[Series/RedDwarf the TV series]].series]], the book version acts as a LotusEaterMachine: it hides its existence from the player's memory, and comes up with plausible reasons for why all their fantasies are coming true. Without someone in the real world to care for them, a "Game head" will typically waste away and die fairly quickly.



** Outrazone (pronounced vaguely like "ultrazone" in a mock-Canadian accent) is a chemical gunk that is apparently [[AIGettingHigh marijuana for mechanoids]].
** A second season episode mentions a powerful hallucinogenic mushroom species native to Titan (one of the moons of Saturn).
** Apparently, by the time before Arnold Rimmer caused Red Dwarf's fatal accident, humanity had learned to create a form of gin out of marijuana. They called it [[CaptainObvious Marijuana Gin]].

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** Marijuana gin, which is probably simply cannabis-infused gin. Lister has drunk it at least once before, according to Rimmer.
** Titan mushrooms, "more popularly known to the space-beatnik community as 'freaky fungus'": hallucinogenic mushrooms grown on Saturn's largest moon, where Red Dwarf had stopped off for shore leave. Lister fed Rimmer some Titan mushrooms as part of a fried breakfast, causing Rimmer to show up to inspection parade almost naked and "attack two senior officers, believing them to be giraffes who were armed and dangerous".
** Outrazone (pronounced vaguely like "ultrazone" in a mock-Canadian accent) is a chemical gunk that is apparently a highly-addictive drug [[AIGettingHigh marijuana for mechanoids]].
** A second season episode mentions a powerful hallucinogenic mushroom species native to Titan (one of the moons of Saturn).
** Apparently, by the time before Arnold Rimmer caused Red Dwarf's fatal accident, humanity had learned to create a form of gin out of marijuana. They called it [[CaptainObvious Marijuana Gin]].
mechanoids]]. Kryten's outrazone-addicted [[RoboFamily "brother"]] Able is TheStoner.
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* The Night Howlers from ''WesternAnimation/Zootopia'' are this.
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** The "[=ThreeEye=]" in ''Literature/StormFront'' is supposed to give its users second sight. Harry is skeptical [[spoiler:until a junkie notices a rather nasty psychic scar of his. It turns out that it actually ''does'' work; it's a potion mass-produced by an EvilSorcerer after he realized that it was addictive]]. Harry also notes that regardless of any other circumstances, the drug will result in insanity more often than not, as [[spoiler: anything seen with Second Sight can ''never'' be forgotten. Wizards are trained on how to handle that. Mundanes are not.]]

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** The "[=ThreeEye=]" in ''Literature/StormFront'' ''Literature/{{Storm Front|DresdenFiles}}'' is supposed to give its users second sight. Harry is skeptical [[spoiler:until a junkie notices a rather nasty psychic scar of his. It turns out that it actually ''does'' work; it's a potion mass-produced by an EvilSorcerer after he realized that it was addictive]]. Harry also notes that regardless of any other circumstances, the drug will result in insanity more often than not, as [[spoiler: anything seen with Second Sight can ''never'' be forgotten. Wizards are trained on how to handle that. Mundanes are not.]]
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** Of these, flects are the most plot-relevant and the strangest: hallucinogenic ''shards of glass'' used by looking into them, which induces intense visions. Mention is made of "viewing parties" where groups of people share a large, intact pane.
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* The plot-relevant drug in ''Literature/PerdidoStreetStation'' is Dreamshit, which is made up of dreams made physical and sawdust. A dose knocks the user unconscious while they experience all the dreams (of all "genres") semi-simultaneously. It's very intense but the hangover doesn't last long.

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* The plot-relevant drug in ''Literature/PerdidoStreetStation'' is Dreamshit, which is made up of dreams made physical and sawdust. A dose knocks the user unconscious while they experience all the dreams (of all "genres") semi-simultaneously. It's very intense but the hangover doesn't last long. [[spoiler:The "dreams made physical" part are the secretions of a slake-moth, an incredibly dangerous monster that eats minds -- Dreamshit is almost literally dream shit, the digested consciousnesses of its victims.]]
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* The ''VideoGame/{{Fallout}}'' series features a wide array of drugs (called chems in universe) that have major stat boosts but come with the risk of addiction and withdrawal symptoms. Many of them have very clear real-life analogs (e.g. Buffout, which boosts strength and endurance, is a steroid, mentats, which boost intelligence and are often taken by students, are adderall, and psycho, which boosts damage but causes some heavy bloodlust seems to be based on the amphetamines given to soldiers in wartime) while some are weirder (e.g. Cateye, which grants night vision, and X-Cell, which boosts all stats).

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* The ''VideoGame/{{Fallout}}'' ''Franchise/{{Fallout}}'' series features a wide array of drugs (called chems in universe) that have major stat boosts but come with the risk of addiction and withdrawal symptoms. Many of them have very clear real-life analogs (e.g. , Buffout, which boosts strength and endurance, is a steroid, mentats, which boost intelligence and are often taken by students, are adderall, and psycho, which boosts damage but causes some heavy bloodlust seems to be based on the amphetamines given to soldiers in wartime) while some are weirder (e.g. , Cateye, which grants night vision, and X-Cell, which boosts all stats).
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* In ''Literature/TheDarkProfitsSaga'', healing potions are a fantastic drug that's essential for adventurers...and also highly addictive. They do exactly what they claim to do, which is heal wounds, but they also provide a general sense of "feeling good" as wounds are healed, resulting in some people becoming "healing junkies", desperate to get their next healing potion, and willing to hurt themselves, sometimes badly, so that it works that much better. [[spoiler: Kaitha]] is one such addict, and the narrative doesn't have to go far to show how dangerous the addiction is to everyone around [[spoiler: her]].
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** The "[=ThreeEye=]" in ''Literature/StormFront'' is supposed to give its users second sight. Harry is skeptical [[spoiler:until a junkie notices a rather nasty psychic scar of his. It turns out that it actually ''does'' work; it's a potion mass-produced by an EvilSorcerer after he realized that it was addictive]].

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** The "[=ThreeEye=]" in ''Literature/StormFront'' is supposed to give its users second sight. Harry is skeptical [[spoiler:until a junkie notices a rather nasty psychic scar of his. It turns out that it actually ''does'' work; it's a potion mass-produced by an EvilSorcerer after he realized that it was addictive]]. Harry also notes that regardless of any other circumstances, the drug will result in insanity more often than not, as [[spoiler: anything seen with Second Sight can ''never'' be forgotten. Wizards are trained on how to handle that. Mundanes are not.]]



* In ''Literature/TheExpanse'', spaceship occupants take a special drug, colloquially called "the juice", when preparing for high-speed maneuvers. This drug is a mixture of various blood thinners, blood vessel reinforcers, adrenaline, and other stimulants that provide protection to internal organs against the crushing gravitational forces of a high-speed boost.

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* In ''Literature/TheExpanse'', spaceship occupants take a special drug, colloquially called "the juice", when preparing for high-speed maneuvers. This drug is a mixture of various blood thinners, blood vessel reinforcers, adrenaline, and other stimulants that provide protection to internal organs against the crushing gravitational forces of a high-speed boost. While it works exceptionally well for that purpose, it's also dreaded by everyone that uses it, as the comedown effect is debilitating at best.
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* Ed Nygma's invention, the "Mind Blender"... er, the Box from ''Film/BatmanForever'', which allows him to suck the neural energy of everybody watching TV with the thing. Taking hits from Nygma's machine is apparently quite addictive. The Riddler himself spends hours on a stylized throne shaped like "The Thinker", jittering like a coke fiend as he sucks up more energy.

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* ''Film/BatmanForever'': Ed Nygma's invention, the "Mind Blender"... er, Blender" a.k.a. the Box from ''Film/BatmanForever'', Box, which allows him to suck the neural energy of everybody watching TV with the thing. Taking hits from Nygma's machine is apparently quite addictive. The Riddler himself spends hours on a stylized throne shaped like "The Thinker", jittering like a coke fiend as he sucks up more energy.
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** ''WesternAnimation/MyLittlePonyEscapeFromCatrina'' features a {{Cat Pe|ople}}rson witch named Catrina who is addicted to a powerful PsychoSerum called witchweed potion. She tries to capture the ponies as ''slave labor'' for gathering the ingredients so that she can make more. Interestingly, while Catrina ''does'' eventually kick the habit and make a HeelFaceTurn, this only happens at the last moment before she would have otherwise died by falling into a well. [[GoodIsNotSoft It's only because of her promise to kick the habit that the heroes save her life]].

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** ''WesternAnimation/MyLittlePonyEscapeFromCatrina'' features a {{Cat Pe|ople}}rson CatFolk witch named Catrina who is addicted to a powerful PsychoSerum called witchweed potion. She tries to capture the ponies as ''slave labor'' for gathering the ingredients so that she can make more. Interestingly, while Catrina ''does'' eventually kick the habit and make a HeelFaceTurn, this only happens at the last moment before she would have otherwise died by falling into a well. [[GoodIsNotSoft It's only because of her promise to kick the habit that the heroes save her life]].
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* Taduki from the ''Allan Quartermain'' novels (see below) also features in ''ComicBook/TheLeagueOfExtraordinaryGentlemen'', in which it's a thinly disguised version of opium, and Allan is hooked on it. ''The League of Extraordinary Gentlemen Century: 1969'' also has the drug of choice in [[TheSixties Swinging London]] as "Tadukic Acid" (or "taddies") instead of LSD.

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* Taduki from the ''Allan Quartermain'' novels (see below) also features in ''ComicBook/TheLeagueOfExtraordinaryGentlemen'', in which it's a thinly disguised version of opium, and Allan is hooked on it.it. While it was a thinly-disguised version of opium in the original it's actually opium in this one. ''The League of Extraordinary Gentlemen Century: 1969'' also has the drug of choice in [[TheSixties Swinging London]] as "Tadukic Acid" (or "taddies") instead of LSD.
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* ''Webcomic/MarbleGateDungeon'': [[https://marblegate.webcomic.ws/comics/276/#content-start Opponi drops]] are apparently dropped into the eyes and leave long-term users with black bags under the eyes. Exactly what the drops do is unclear, but they are implied to be highly addictive and stereotyped as a "poor person drug". Ozzi is revealed to be a former Opponi user (he has the black bags, but hasn't been seen using drops on-page).
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* ''Anime/CowboyBebop'': The Red Eye, a stimulant which is sprayed in the eye and grants incredibly fast reaction times and dissociation from reality.

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* ''Anime/CowboyBebop'': The Red Eye, Eye is a stimulant which is sprayed in the eye and grants incredibly fast reaction times and dissociation from reality.reality. The first episode deals with a man trying to sell a stolen supply of Bloody Eye, a "purer" form of Red Eye.
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* ''Film/RoboCop2'' has "Nuke", which is "injected" via disposable eyedrop vials. There is [[ChemicalMessiah a cult based around the drug]].

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* ''Film/RoboCop2'' has "Nuke", which is "injected" via disposable eyedrop vials. There is [[ChemicalMessiah a cult based around the drug]]. It is implied that the drug is playing off of or countering negative emotions made by the brain's chemistry. Nuke actually comes in a number of different varieties, including Red Ramrod, White Noise, Black Thunder and Blue Velvet.
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* The "true wine" brewed by the Soma Familia in ''Literature/IsItWrongToTryToPickUpGirlsInADungeon'' is alcohol so impossibly delicious that [[InstantTasteAddiction a single sip leaves you addicted to it]]. This has led to the Soma Familia essentially devolving into an entire Familia of junkies, [[DescentIntoAddiction desperate to scrape up enough wine to afford their next fix]]. They even deliberately addict particularly promising up-and-coming adventurers so they'll bend their considerable fortunes and talents towards producing more of Soma's "true wine".
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** Umpty is a candy which is simply so extremely delicious that anyone who eats it develops an instant psychological addiction to it and will do anything to gain more Umpty to eat.

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** Umpty is a candy which is simply so extremely delicious that anyone who eats it develops an instant psychological addiction to it and will do anything to gain more Umpty to eat. Because it lacks a clear biochemical side to the addiction, it has proven very difficult to develop treatments to wean addicts.
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Juggalo TRS cleanup, now a Useful Notes page.


** The [[OurTrollsAreDifferent trolls]], a race of aliens plagued by violent night terrors, sleep in cocoons filled with a powerful sedative gel called sopor slime, which has effects similar to marijuana when eaten. [[LoveFreak Gamzee]] [[{{Juggalo}} Makara]] is a [[TheStoner chronic user]]. [[spoiler:[[SplitPersonality For]] [[MadArtist a]] [[AxCrazy good]] [[MonsterClown reason]]!]]

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** The [[OurTrollsAreDifferent trolls]], a race of aliens plagued by violent night terrors, sleep in cocoons filled with a powerful sedative gel called sopor slime, which has effects similar to marijuana when eaten. [[LoveFreak Gamzee]] [[{{Juggalo}} Gamzee Makara]] is a [[TheStoner chronic user]]. [[spoiler:[[SplitPersonality For]] [[MadArtist a]] [[AxCrazy good]] [[MonsterClown reason]]!]]

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* In ''Literature/DragonBones'', Muellen, the mother of the protagonist, is drugged most of the time. One of her favorites is "dreamroot", but she also has other plants in her garden. It's what happens when a botanist becomes severely depressed -- she was a well-adjusted, but delicate soul in Ward's childhood. Then her abusive husband became too much to bear, and she started seeking solace in the psychoactive plants in her garden. She doesn't seem to be quite there even when she's not drugged, having effectively fled reality and turned herself into a full-time {{Cloudcuckoolander}}.


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* ''Literature/{{Hurog}}'': In ''Dragon Bones'', Muellen, the mother of the protagonist, is drugged most of the time. One of her favorites is "dreamroot", but she also has other plants in her garden. It's what happens when a botanist becomes severely depressed -- she was a well-adjusted, but delicate soul in Ward's childhood. Then her abusive husband became too much to bear, and she started seeking solace in the psychoactive plants in her garden. She doesn't seem to be quite there even when she's not drugged, having effectively fled reality and turned herself into a full-time {{Cloudcuckoolander}}.

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* Kef from ''Literature/AncillaryJustice''. It suppresses emotions, so people either take it in the mistaken belief they will become [[TheSpock transcendent beings of pure rationality and logic]] or they use it to dull emotional trauma. If used for the latter, it can be incredibly habit forming and addictive.


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* Kef from ''Literature/ImperialRadch''. It suppresses emotions, so people either take it in the mistaken belief they will become [[TheSpock transcendent beings of pure rationality and logic]] or they use it to dull emotional trauma. If used for the latter, it can be incredibly habit-forming and addictive.

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** ''Series/StarTrekPicard'' has the snakeleaf, which one character smokes like it's offworld marijuana.

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** ''Series/StarTrekPicard'' has the snakeleaf, which one character ''Series/StarTrekPicard'':
*** Raffi
smokes snakeleaf like it's offworld marijuana.marijuana.
*** A Ferengi named Sneed created a concoction that's sprayed into the eye. He calls it "splinter" because it makes the user feel like they're being repeatedly pulled apart.

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