History Main / FantasticDrug

* Franchise/KamenRider:
** ''Series/KamenRiderW'' has the Gaia Memories, specialized items forged from the world's internal data which people use to become [[MonsterOfTheWeek Dopant]] and are distributed by criminals around the city of Futo. While not directly compared to drugs, the series makes many very unsubtle allusions to them being such, with the Dopants MeaningfulName being in part the word "doping", one villain expressing outrage when he hears they are being distributed to children, them being directly injected into the body via a marked spot on their body given by a dealer, possessing addictive qualities, and gradually rendering the users personalities violently unstable over time, eventually either killing or severely injuring them after their bodies are unable to sustain their developing powers. Notably, while both the heroes and villains also use them to battle, as is tradition in ''Rider'', this involves the use of equipment specifically designed to harness the power safely.
** ''Series/KamenRiderFourze'': The Astro Switches used by [[MonsterOfTheWeek Zodiarts]]. Like Gaia Memories, the Switches are distributed to high schoolers by the villains, and their use is shown to result in addiction and insanity. In one episode, a previous Astro Switch user is shown having withdrawal symptoms, refusing to go to school out of fear of receiving another Switch and having a relapse.

* ''VideoGame/BioShock1'' had ADAM and Plasmids. These originally were to grant people temporary superpowers; however, the substance proved to be extremely addictive, in addition to causing physical and mental deterioration with prolonged use, which helped spark a CivilWar. By the time the player arrives, Rapture is populated almost exclusively with ADAM-crazy slicers.

* ''WesternAnimation/BojackHorseman'': In season 5, [=BoJack=] injures himself during a stunt and is prescribed what he calls "feelbetterin", described as a highly addictive opioid. Former DoctorFeelgood Dr. Hu asks him whether he's taking "oxyproxylcortisoid", which may or may not be a BlandNameProduct of the infamously abused opioid oxycodone. [[spoiler:By the end of the season, [=BoJack=] ends up suffering from paranoid delusions, hallucinations, nightmares, and violent rages, [[ArtisticLicensePharmacology all of which are more associated with stimulant abuse than opioid abuse]].]]

* ''Fanfic/AdventuresOfTheMorningStar'': Like it's [[WesternAnimation/{{Arcane}} source material]], this fic has the drug, Shimmer. It turns people and rats into monsters that do whatever Singed and Silco say.

* ''Fanfic/AYoungGirlsGuerrillaWar'': Once stuck in a position of leadership, Tanya's magic becomes this: constant use of mental stimulation spells results in something similar to wartime usage of amphetamines due to her refusal to take any time off.

* In ''WebVideo/{{RWBY ABRG}}'', the Schnee's are involved in the drug trade. Dust, which is usually for weapons, is often used recreationally.
* Street drugs derived from Night Howler serum are very common in ''WesternAnimation/{{Zootopia}}'' fanfics. For instance, in ''Fanfic/TakeAStand'', "Morrigan" is a performance enhancer used in illegal pit fights.

* The Night Howlers from ''WesternAnimation/Zootopia'' are this.

* ''Film/AttackOfTheClones'' had death sticks, something which the writers of the Holonet News promo [[https://web.archive.org/web/20120512054854/http://www.holonetnews.com/49/life/13328_1.html had some fun with]]. The ''Franchise/StarWarsExpandedUniverse'' features harder drugs such as ryll and glitterstim (which was, incidentally, the "spice" that Han used to smuggle for Jabba the Hutt).

* ''Film/{{Barbarella}}'': At one point Barbarella smokes "essence of man" (made by trapping a guy in a giant hookah). She only smokes briefly before getting caught by the villains, so we don't see the effects.

* ''Film/TheBatman2022'' features a drug with the street name of "drops" as a central plot element.

* ''Film/AClockworkOrange'' (film and book) features substances like "synthemesc" (presumably mescaline or a close analogue), "drencrom" (presumably adrenochrome) and "vellocet" (given the resemblance to "velocity", probably "speed"-like amphetamines), all normally mixed into milk (thus why it's called ""milk ''plus''", as in milk ''plus'' whatever you put in it).

* ''Film/RepoTheGeneticOpera'': [=GeneCo=], the company that makes artificial organs and cosmetic surgery, also sells a highly addictive painkiller called Zydrate that is used in its surgeries. It comes in a little glass vial[[note]] A little glass vial?[[/note]] and glows blue. LovableRogue Graverobber sells black market Zydrate that he extracts from the brains of corpses.

* ''Film/SexualChemistry'': The key to this film's plot is a drug that not only transform the user into the opposite sex, but makes them younger, grows their hair and nails (and massive breasts), and epilates their body. It also seems to apply makeup. Given that the formula involved input from someone who's specifically stated to be a witch, the writers evidently had to admit that this looked more like magic than science.

* In ''Literature/TheDarkProfitsSaga'', healing potions are a fantastic drug that's essential for adventurers...and also highly addictive. They do exactly what they claim to do, which is heal wounds, but they also provide a general sense of "feeling good" as wounds are healed, resulting in some people becoming "healing junkies", desperate to get their next healing potion, and willing to hurt themselves, sometimes badly, so that it works that much better. [[spoiler:Kaitha]] is one such addict, and the narrative doesn't have to go far to show how dangerous the addiction is to everyone around [[spoiler:her]].
* From the beginning, drugs figure among the limitations on Literature/{{Deryni}} powers in the works of Creator/KatherineKurtz:

*** ''TNG'' also came up with synthehol, a {{justified|Trope}} version of this trope. It's a replacement for alcohol in beverages that can (apparently) be flushed from the system quite rapidly if you're called back to duty while in Ten Forward. The science book ''Life Signs: The Biology of Star Trek'' went so far as to figure a way how it could work: broken down by adrenaline when RedAlert sounds.
*** The ExpandedUniverse explains that synthehol was originally invented by the Ferengi for use in scams: a Ferengi con artist would invite the mark to drink, giving the mark their strongest booze while the Ferengi only drinks synthehol and fakes being drunk out of his gourd. But they quickly realized that there was a huge market for an alcohol substitute that lets people get as drunk as they like, but also lets them sober up as soon as they need to and skip the hangover. So just selling synthehol to everybody was an easier way to make money.

*** Luhix, made from the powdered stalks of a specific Abyssal plant, is sprinkled into a bleeding, usually self-inflicted wound that is then bound shut or magically healed. The initial effect is intense pain and 1 point of damage to all ability scores, followed by [[FeelNoPain an immunity to pain]] and a 1 or 2-point ''bonus'' to all ability scores. It's also the most viciously addictive drug in the chapter.

* ''The Book of Vile Darkness'' for ''TabletopGame/DungeonsAndDragons'' lists several fantastic drugs along with game rules for them (presumably because it's a book about everything that [[DrugsAreBad is bad]]). One of the nastier examples is distilled pain, which, [[ExactlyWhatItSaysOnTheTin well]]. There are naturally rules for addiction, but fortunately you can always remove that if you have access to the right spell.
** Also, in the Known World/Mystara setting for D&D, there's an Alphatian drug called zzonga.
** Somewhere between Fantastic Drug and AlienCatnip is Lurien Spring Cheese from the ''TabletopGame/ForgottenRealms'', also known as Halfling Cheese, mind cheese, and cheeeese. To humans, it's a rather unpleasant dairy product; to halflings, it's the most powerful narcotic imaginable.

** ''VideoGame/FinalFantasyVII'' occasionally dips into this with Mako. In combination with Jenova cells it gives people superhuman abilities and [[GlowingEyesOfDoom glowing eyes]] -- when exposed to high levels souls become intertwined and a psychedelic VisionQuest results. It's also poisonous, physically addictive, and the Mako therapy use is very bad for one's mental health.

* ''Series/{{Tracker}}'' had an Enixian who was making a drug that his species used as eyedrops into their highly sensitive eyes. It was destructive and often fatal to humans, which meant Cole and Mel had to put the producer out of business.

* Subverted in the ''TabletopGame/MutantsAndMasterminds'' fan setting ''[[https://www.echoesofthemultiverse.com/viewtopic.php?t=1631 The World Less Magical/The World in the Aftermath]]'', in which thionite is an expensive form of cocaine treated with the setting's GreenRocks -- a procedure that does not actually alter its effects in any way.