- Bizarro Episode:
- The later season episode where Fran is approached by a woman who states that, due to a mix-up years ago, she might be Fran's actual mother and not Sylvia (and for a second, Fran believes it when she hears the woman's laugh, which sounds freakishly similar to Fran's own unique laugh). Of course, it turns out she's not, and the woman is never mentioned ever again.
- The animated Christmas Special "Oy to the World", in which Fran and Brighton are magically whisked to the North Pole, where they must protect Christmas against the wrath of ice princess "C.C. the Abominable Babcock".
- Foe Yay: C.C. with Niles and, to a lesser extent, Fran.
- "Funny Aneurysm" Moment:
- In the episode where Maxwell and Fran have to deal with the tabloid, we see a scene where the paper is printing lies about John F. Kennedy, Jr. And mere moments later, the tabloid editor openly brags about the way his paper exploits Princess Diana. Sadly, we all know what happened to both of these public figures within mere years of this episode's original airing...
- Even worse, Diana's eventual death occurred when she was trying to escape from the paparazzi..who happen to be the primary antagonists of this very same episode.
- Also, the fact that both Fran and her mother were so obsessed with Fran having children, it can be kind of hard to watch after you hear about Fran Drescher's battle with uterine cancer that required a radical hysterectomy and left her infertile with no children.
- In one episode, Sylvia has a freak-out where she threatens to throw herself in the Hudson River, to which Fran responded "Ma, flooding New Jersey is not gonna solve anything!" Flash forward to Fall 2012 and watch what happened to the state after Hurricane Sandy.
- Germans Love David Hasselhoff: The show the was immensely popular in many countries outside USA (Argentina, Australia, Chile and Russia, to name a few). It's also very popular in Mexico. It does help the Mexican dub was really good, and the network that had the rights to broadcasted it there was very fond of put its reruns for many years.
- Harsher in Hindsight:
- In one episode, Fran fears that her mother might be having an affair (she's not, she's just flirting with the butcher to get low priced meat) and in another, a lonely and desperate Niles asks himself if Sylvia would ever leave Morty. Skip ahead to the final season, and Sylvia really does start having an affair and almost leaves Morty.
- Fran's favorite store, Loehmann's, had filed for bankruptcy and have been liquidated before being converted to a shopping website.
- The episode in which Fran thinks she's pregnant only to reveal it was a false positive on the test leading to her crying softly to herself on the hospital bed, is a lot harder to look at after a medical procedure left the actress infertile and incapable of ever bearing children.
- Hilarious in Hindsight:
- In "Imaginary Friend", mention is made of Maxwell's great-aunt Hermione and her giant hoot owl in regards to the Sheffield family's history of dementia.
- While Maggie was doing that particular research, she also noted that Maxwell was the only member of his family to not have the title of "Sir" or "Lord" in his name (except for another uncle who thought he was a leprechaun.) In reality, Charles Shaughnessy is the 5th Baron Shaughnessy, so he is an actual Lord.
- The season 6 Thanksgiving episode (the one in which Fran finds out she's pregnant for real). Morty is seen watching the football game, and he said the he should have bet on Pittsburgh. The Steelers actually did play the Detroit Lions that Thanksgiving, and they lost on a controversial coin flip, now forever infamous to Steeler fans.
- As the series ended, Maxwell moved to Hollywood and left the theater business. After that, it was announced in real-life media Cats would no longer be on stage.
- In an early season, while snowed in at Sylvia's house, Maggie begins to flirt with another boy in the building named Kenny. At the end of the episode, he says that after he graduates from medical school, he's going to go right into stand-up comedy as kind of a giant joke on his parents. Funny then, but since Ken Jeong did the same thing (although he did spend a lot of time as a doctor and did stand-up as a hobby,) it's even funnier.
- Ho Yay: Maxwell and Niles occasionally had some. Like when Maxwell revealed he was going to propose to Fran, Niles reacted as if he was getting proposed to.
- Jerkass Woobie: CC. She may be a horrible, greedy, selfish person, but all the crap she takes, you can't help but have a tiny bit of sympathy for her.
- Les Yay:
Sydney: Well, that's a shame I would've asked you out.
- Fran and Val.
- And, overlapping with Foe Yay, Fran and C.C.
- To make the circle complete, Val and C.C.
- Played with when Maxwell hires a lesbian promoter (he thought she was straight) and she mistakes Fran for being gay since Fran "is over 30 and she has no man in her life." Fran responds with "I'm not gay, I'm just pathetic."
- Immediately afterward:
Fran: Great, a gorgeous professional asks me out and it's a woman! (brief, thoughtful pause) You're not Jewish, are you?
Sidney: (shrugs) Sorry!
Fran: Aw, that's too bad. We were this close to makin' my mother happy!
- Fran's obsession with Barbara Streisand would occasionally dip into a Psycho Lesbian Stalker with a Crush territory as well. She had a wig like Streisand's hair, stole her shoe when she visited her house, and when her sister Rosalind Kind visited the house, she declared "Close enough, same DNA!!!" and began kissing her feet.
- Magnificent Bastard: Niles to CC.:
C.C.: My mental health is just a sick GAME to you, isn't it?!Niles: Rack 'em up, let's play again sometime.
- Memetic Mutation: On the LiveJournal gossip community Oh No They Didn't, it's pretty much obligatory to include "commentary" from Maxwell Sheffield in Broadway-related posts. He still has it in for Andrew Lloyd Webber, but he's not particularly impressed with Spider-Man: Turn Off the Dark either.
- No Yay: Niles and Nanny Mueller in "The Nanny-In-Law". That's not just Squick, that's Nightmare Fuel! Noted in-universe when Maxwell—after seeing them—stammers "I...I...I don't ever want to see that again!"
- Retroactive Recognition: James Marsden as Eddie, Maggie's first boyfriend in the first season.
- Unpopular Popular Character: C.C. wasn't well liked by anyone in the main cast but Maxwell (and Niles, not that you'd know it) but was a fan favorite.