The sixth direct-to-video installment of the Scooby-Doo franchise, Scooby-Doo and the Monster of Mexico was produced by Warner Bros. Animation and again directed by the guy who brought us Scooby-Doo comics, Scott Jeralds.Once more the film was done in a retro format resembling the classic Hanna-Barbera 1970s cartoons and this movie was the final time featuring Frank Welker, Casey Kasem, Heather North and Nicole Jaffe from The New Scooby-Doo Movies together, as this was North and Jaffe's final time voicing Daphne and Velma respectively. This was also North's final project before her death in 2017.The movie begins with Fredís Mexican pen-pal inviting him and the rest of the gang to come visit him in Veracruz, Mexico. Fredís friend Alejo Otero owns a fancy hotel and offers to let them all stay while vacationing. The gang decides itís a good chance to take a break from solving mysteries, only to find thereís a new mystery waiting for them when they arrive in Veracruz. The mythical Mexican monster El Chupacabra is supposedly tormenting the residents of the town and chasing away visitors. Of course, the gang begin investigating around the town to see what they can turn up.
- Big Bad: Mr. Smiley and Charlene.
- Bitch in Sheep's Clothing: The museum guide, also known as Charlene.
- Dating What Mommy Hates: After Charlene's revealed as one of the culprits, Luis and Alejo's mother reveals that she never really liked her, even calling her as a "Bruja" (the Spanish word for "Witch").
- Critical Research Failure: In-universe, Mr. Smiley is terrible at passing himself off as a ghost of a Mexican man, or writing Spanish. Just how was he going to carry off his scheme again?
- Damsel in Distress: Daphne get kidnapped in a tourist attraction mid-film in an attempt to scare away the gang, she is found outside shortly after.
- Dirty Coward: Luis sees himself as this after hearing his brother calling for help but being too scared to help, so he claims El Chupacabra knocked him out. He's ashamed of it, but Alejo forgives him, claiming that there are worse things than being a coward.
- Either "World Domination", or Something About Bananas: Fred's attempt to speak Spanish leave a little something to be desired.
- Evil Cannot Comprehend Good: Mr. Smiley and Charlene mock Alejo for not wanting to break the promise he and the rest of his family made to his and Luis's deceased father about not selling the family business.
- Gold Digger: Charlene.
- Gratuitous Spanish: Justified since the entire film takes place in Mexico. In fact, the fact the villain doesn't speak Spanish is an important plot point.
- Maybe Magic, Maybe Mundane: So how much of the things at the pyramids were special effects? And then (most of) the gifts Alejo's family leave at his father's grave vanish...how did that happen?
- Politically Incorrect Villain: Mr. Smiley pretends to be the ghost of the Alejo and Luis's father telling them to sell their hotel. But Velma pointed out their real father spoke only Spanish. When he's found out, he complains that they should have learned English.
- Reality Ensues: When the gang was chased by a mob of angry tourists, they used the disguises like they always did in their previous adventures. The angry tourists saw through their disguise immediately.
- Role Reprisal: Again, Heather North and Nicole Jaffe reprising their roles of Daphne and Velma, respectively.
- "Scooby-Doo" Hoax
- Shout-Out: "Pay no attention to that man behind the curtain."
- Special Effects Failure: In-Universe; the "magical eagle" is very obviously just a machine. However, it's convincing enough to fool the gullible tourists.
- Spot the Thread: Freddy when reviewing the footage of the vandalized Mystery Machine deduces that the perpetrator doesn't speak Spanish due to the word manana missing the tilde, the ~ symbol.