Cute Monster Girl: All of the characters, from the Villain Protagonist and her ex-lover to the slaves the Queen is trying to capture. The former looks like a beautiful woman's upper torso mounted on the lower body of a giant spider, drider-style, while the latter are essentially Human Aliens, being pretty women with unnatural red or yellow skin tones.
God Save Us from the Queen!: Your main character is a tyrannical lesbian who forces native Martian women into being her sex-slaves; the whole plot of the game is that they are revolting, so you have to recapture them and "re-educate" them. The "Tarantula Queen", the Hero Antagonist, is no better, as she started the revolt to get back against the Spider Queen for dumping her.
Harem Seeker: The Queen is a more aggressive version than most.