Actor Allusion: Wilbur Nelson who appeared in the "American the Beautiful" episode was voiced by Alan Young, who previously played two other characters sharing the first name: Main character Wilbur Post from Mister Ed and Wilbur Bowser in an episode of Encounter.
Duckman is said to have had a relationship with a Seinfeld-obsessed blind woman who thought he was Jason Alexander in a duck suit.
Composers: Scott Wilk and Todd Yvega composed for all 70 episodes. Various music and songs from Frank Zappa were also used in the first two seasons.
The Other Darrin: When Dana Hill (the original voice of Charles) died while in a diabetic coma, Pat Musick was hired to replace her.
Screwed by the Network: While USA treated the first three seasons fairly well (even though it did air on Saturday evenings, which is when TV ratings aren't really sky-high), most of season 4 aired in the wee hours of the morning. Is it any surprise it was canceled after that?