Marvelous Melmo is an early Magical GirlManga and Anime created by Osamu Tezuka about a nine-year-old girl named Melmo, who must raise her two younger brothers after their mother is killed in a car accident. To help with this, her mother briefly returns as a ghost and gives Melmo a bottle of magical candies: the blue candies will make her older, and the red ones will make her younger. The story follows Melmo as she attempts to take care of her brothers and navigate the confusing world of adults, despite still being mentally nine years old.
Full-Frontal Assault: In episode 4, Melmo fends off a group of attack dogs by throwing de-aging candies into their mouths, all while in her birthday suit. (She had just de-transformed from an animal form and thus was without clothes.)
Improbable Aiming Skills: Melmo is improbably good at throwing candies into the mouths of people and animals alike, even if they're a good distance way and/or trying to attack her.
Improbable Weapon User: Melmo finds very inventive ways of using her candies to defend herself, usually by tossing them into people's or animals' mouths or by dissolving them in water and then splashing the water on a relevant plant or animal.
Real Men Wear Pink: Melmo's spiky-haired butt-kicking motorcycle-riding boyfriend, Jiro, is usually seen wearing a bright pink shirt.
Reincarnation: The final episode shows Melmo, now a married woman, using her last candies to find out that her mother had somehow reincarnated in her own granddaugther, thus reuniting both women but with swapped roles.
Sexophone: Adult Melmo's fanservicey scenes are accompanied by a sexy saxophone leitmotif.
Shapeshifter Mode Lock: As soon as Melmo discovers the shapeshifting powers of the candies, her younger brother Totoo shapeshifts himself into a small frog. Too bad he's then unable, for almost half of the series, to eat the required candies (that now are bigger than his mouth and stomach).
When Melmo starts abusing the power of the candies, by using them for selfish reasons, the angels responsible from empowering them withold their blessing. Too bad Melmo had just transformed herself in a dog. After refusing to change her back for a whole episode, eventually the angels settle for giving Melmo her powers back, but with a finite number of candies (before, they used to renew themselves in the jar).
Shapeshifting: Early in the series, Melmo discovers that, by consuming both types of candies at once and thinking to a certain animal, she could de-age herself to embryonic stage and re-age as the animal she was thinking to, as, according to the evolutionary theory, a human embryo is genetically connected to every other lifeform. That's not exactly how science works, but for Melmo is close enough.