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Anime and Manga
- Nobunaga no Chef: Kennyo serves French macaroons to Oda Nobunaga, and demonstrates that they are harmless when he and his staff begin nibbling on some themselves. However, he then encourages Nobunaga to eat three macaroons at once, whereupon the high concentration of nutmeg sends Nobunaga into overdose and almost results in his death.
- In Ooku, O-Shiga sacrifices her own life in an attempt to kill the sociopathic Harusada by sharing poisoned food with her. She was intending to slowly poison Harusada without killing herself, but was driven to desperate measures when Harusada decided to kill Ienari. Harusada just survives, but is left completely paralysed and forced to helplessly watch all the good people she worked against succeed.
- The Princess Bride features a "battle of wits" between Vizzini and the Man in Black. The Man in Black sets up two goblets of wine, shows Vizzini a rare, odorless, and colorless poison powder then challenges Vizzini to determine which goblet is poisoned. Vizzini does a Look Behind You and then does the Poisoned Chalice Switcheroo, and makes his choice about which goblet to drink. Vizzini then waits for the the Man in Black to drink, and when the Man in Black does so with no hesitation, it leads Vizzini to believe that the Man in Black thought he was drinking from the "safe" cup, which Vizzini now has thanks to the switch, so he drinks too thinking that he has won. The Man in Black had Acquired Poison Immunity and had poisoned both cups, leaving Vizzini Out-Gambitted (and dead).
- In Red 2 when Bailey is in custody he gets rid of his captors by sliding open the bottom of his shoe to reveal an ampule of nerve gas and a syringe of antidote. He gives himself the antidote and gasses everyone else around.
- In The Emperor's New Groove, Yzma's plan to poison Kuzco fails because Kronk forgot which cup had the poison, so he had to mix all the drinks together and he and Yzma only pretend to drink with Kuzco. It didn't matter anyway if they had, since Kronk had used extract of llama instead of poison, and only succeeds in turning Kuzco into a llama.
- This pops up several times in A Song of Ice and Fire:
- At the start of the second book, Stannis' Honest Advisor Cressen, who loves Stannis like a son, attempts to do this to the Ambiguously Evil Sorceress Melisandre, who he feels is leading Stannis astray. He expects this to be a Taking You with Me, however Melisandre is protected by her magic, (and foresaw the event beforehand and gave Cressen a chance to back out) while Cressen dies.
- In a prequel story, a Dragon Rider named Ulf the White turns into The Starscream in the middle of a civil war and opts to try to crown himself king. A knight from the side Ulf was fighting for comes to talk with him bringing poisoned wine, but Ulf suspects something is up and won't drink until the other man does. The knight quaffs a whole glass, after which Ulf drinks too and they both die.
- In the climax of Airman, Bonvilain attempts this with Queen Isabela and Conor's parents while they're having a toast. However, they suspect what he's up to and refuse to have their drinks, and he's later weakened enough by his own poison for Conor to kill him.
- The Professional Killer Achimas from The Death of Achilles recalls one of his hits where he killed an old rich industrialist by spiking the wine both of them drunk with a rare poison that caused cardiac arrest if the victim's heart started beating faster than usual. After finishing the bottle, Achimas told the industrialist that his nephew was planning to kill him, causing an immediate death, then walked home very slowly and carefully to give the poison enough time to denaturate.
- A similar incident happened in The Belgariad, where a tolnedran politician killed another by sharing with them a poison that kills the drinker if they get angry.
- In the Lord Peter Wimsey novel Strong Poison, the villain shares a poisoned omelette with the victim after building up a tolerance to arsenic. note
- In Marlfox, Queen Silth is offered wine by her daughter Lantur. After a round of I Know You Know I Know Poisoned Chalice Switcheroo, a panicking Lantur drinks the wine from her own cup and collapses, Silth drains the wine from the remaining cup... and dies, as Lantur reveals the poison was in Silth's cup the entire time.
- Swartt Sixclaw gets rid of a rival warlord by offering him wine and an ornate cup to drink it from, taking a swig from the wineskin first himself to prove it's safe. The warlord has his Giant Mook drink first before drinking, both enjoying the wine. The next morning, the latter two are found dead, and when the captain interrogates Swartt, he drinks the rest of the wine to prove it isn't poisoned (the wine wasn't poisoned, but the cup was).
- In the Agatha Christie novel Death Comes as the End, the murderer deliberately drinks poisoned wine before his brother comes to join him, being sure to only drink enough to make him sick. Because he is known as a man of moderation, while his brother tends towards excess, no one is surprised that he has only consumed a little of the wine and survives, while his brother consumes a lot and dies. And because he was the first to drink the wine, it looks like he was the killer's target and the brother was collateral damage.
- In Dune, Dr. Yueh Wellington put a poison capsule tooth on Duke Leto Atreides's mouth and told him that when he gets captured by the Harkonnens and delivered to Baron Vladimir Harkonnen himself, he must bite the capsule when the Baron goes near him in order to ensure that the poisoned gas would be released. Since they're both aware that Leto would not make out of this alive, Yueh reassures to him that Jessica and Paul are safe and out of the Harkonnens' way. The plan nearly worked except Leto only got to kill the Harkonnen's mentat, Piter de Vries, and several soldiers while the Baron was lucky to step out of the distance.
Live Action TV
- This is how how Gus defeats the Juarez Cartel in Breaking Bad. Gus brings a rare and expensive bottle of tequila (which is of course poisoned) to the meeting with the heads of the Cartel where they think Gus is going to surrender to them. Don Eladio, who is Properly Paranoid, refuses to drink until after Gus does so. Gus apparently anticipated this, as shortly before the toast he took a pill of some kind and shortly afterward he excuses himself, goes to a bathroom, and tries to vomit up the poison. Gus is still affected by the poison and would have died without prompt medical care, but he fares better than the heads of the Cartel, who drop like flies within minutes.
- When Captain Sheridan is captured in Babylon 5, he is Denied Food as Punishment for several days to soften him up before an interrogator begins torturing him into a False Confession. During one of the earliest stages of interrogation, the interrogator begins eating a sandwich right in front of the ravenously hungry Sheridan, and offers Sheridan a piece if Sheridan says what the interrogator wants to hear. Sheridan uses some Exact Words to Take a Third Option, and the interrogator appears impressed enough to give Sheridan the food anyway. Sheridan gets paranoid just before eating, until the interrogator points out "You saw me eating it, didn't you?" Sure enough, later in the scene the interrogator reveals that he has Acquired Poison Immunity, and the food makes Sheridan sick.
- The Twilight Zone (1959) episode "The Jeopardy Room". A Soviet commissar tricks a defector into drinking wine mixed with a sleep drug by drinking first. He built up an immunity to the drug by repeatedly taking increasing doses over time.
- In Versailles, the lover of Fabien Marchal, the king's chief of security, is in reality a spy from the faction who wanted to take down Louis XIV. After making fall him in love, she gives Fabien a "love potion" which both drink before making out, just to see her later vomit it thanks to some ingredients she ate previously that would throw out the poison. Later, Fabien is seen not well, including Incurable Cough of Death and Blood from the Mouth.
- In The Expanse when their complicity in the Protomolecule scheme is about to be exposed Undersecretary Errinwright and the Martian ambassador share a bottle of scotch that contains a poison tailored specifically to the ambassador's physiology and his death is passed off as suicide.
- Fear Itself: The episode "Eater" contains a variation. The last surviving cop, having been disarmed, wounded and cornered in a closet with no escape route, makes the decision to eat and powder herself in rat poison. Thus when the unstoppable cannibal serial killer-Voodoo sorcerer kills her shortly after by biting her throat out he is poisoned and dies.
- Game of Thrones Season 5 finale, "Mother's Mercy", has Ellaria Sand poisoning Myrcella Baratheon by kissing her on the lips. After getting on board on the ship that is heading back to King's Landing, Myrcella started to nosebleed and slowly collapsed into her father's arms. Meanwhile, Ellaria also had a nosebleed after being affected by the poison but she administered herself with the antidote immediately which was provided by her daughter.
- In some versions of Snow White, only half the apple is poisoned, so the queen eats the half that's not poisoned, leaving the poisoned half for Snow White.
- In one episode of Samurai Jack, there's a scientist (presumably working for Aku) who poisons a well in an attempt to kill Jack. Jack seems to realize that something is up at the last second before drinking, but then appears to drink from the well, and afterwards he falls down and seemingly dies. When the scientist goes to check the body, Jack suddenly turns towards him and spits out the poisoned water into the scientist's mouth, and because the scientist inadvertently swallows, it ends up killing him instead.
- In one episode of Star Wars: The Clone Wars Anakin and Obi-wan are partying with Hondo's crew of pirates, and are savvy enough to discretely swap drinks with two of the pirates. But then it turns out all the drinks were drugged and they wake up in a cell.