- "I can heal the sick, an' even raise the dead—
And make you little girls talk outta your head!"— Willie Dixon, "Seventh Son"
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- Johnny Thunder, an early member of the Justice Society of America, got his powers from being the seventh son of a seventh son, born on the seventh hour of the seventh day of the seventh month of 1917.
- The villain Man-Witch from Common Grounds is a deliberate case; when his mother found out her husband was a seventh son she decided to have seven sons to see if it worked. It did. Incidentally, it really is seven sons; they had somewhere around fifteen children because girls kept messing up the math.
- In Fables, the prophecy concerning Snow and Bigby's seven children claims that the seventh child will live to ages old and is blessed by heaven. This child is almost certainly the zephyr Ghost, the youngest of the siblings.
- In Weres Harry Tom Riddle's shade was extremely upset that Ginny had given his diary to Luna.
"...The Weasley brat is the seventh child and first daughter born in seven generations. Sacrificing her soul while absorbing her magic would have been enough to give me life of my own..."
- In Son of the Desert Trisha is the seventh daughter of a seventh daughter, a batsheva which means she has a sacred place in Ishvalan society. Everyone is allowed to call her by name, marrying her will allow someone to start a new family name and she's free to speak her mind around anyone. She marries the immortal Hohenheim.
- In The Seeker, a movie based on Susan Cooper's novel The Dark Is Rising, Will is the seventh son of a seventh son, and destined to save the world from darkness.
- In Ernest Scared Stupid, Old Lady Hackmore says "you're the seventh son of the seventh son" when listing all the auspices that make Ernest The Chosen One for fulfilling his ancestor's legacy and defeating Trantor the Troll once and for all. (It's not clear if she's being metaphorical or not, though, especially since she refers to him as the direct descendant of Phineas Worrell.)
- In Hope and Crosby's Road to Bali, they sing "Hoot Mon", which has the lyric "The seventh son of the seventh son of a son-of-a-gun from Perrrrrrrrrth".
- In Seventh Son, the trope is unsurprisingly played straight as Tom is the seventh son of a seventh son. At the same time, he's the offspring of a human father and a witch mother, making him a unique combination with astounding potential.
- Taken Up to Eleven in Orson Scott Card's The Tales of Alvin Maker. Alvin is not only a seventh son, he is the seventh son of a seventh son, his parents' thirteenth child, and to top it all off was born with a caul, and is a powerful "maker"—a rare and powerful form of magic. The first novel in the series is even named Seventh Son.
- Alvin's younger brother, interestingly, is also (sort of) the seventh son of a seventh son, because their oldest brother died just after Alvin was born. Calvin doesn't have quite Alvin's level of power, but he's more powerful than average by a good bit.
- And their father, Alvin Sr., is also above average.
- In the Discworld series, the magic number is eight, not seven, so the eighth son of an eighth son is a wizard.
- In Equal Rites, Eskarina is the eighth daughter of an eighth son, which isn't supposed to work, but somehow it does. Women are supposed to be witches, not wizards, but Eskarina is simply too wizardy.
- In Sourcery, we learn that the eighth son of an eighth son of an eighth son becomes a super-powerful "sourcerer", a wizard that is actually a source of magic, and almost too powerful for the world to bear. (This is one of the reasons wizards are discouraged from having sex.)
- In Septimus Heap, Septimus is a powerful wizard, and the seventh son of a seventh son.
- In The Forgotten Beasts of Eld, when Sybel is puzzled that Coren, an ordinary human, knows so much about the magical beasts under her care, he simply explains that he's the seventh son of a seventh son.
- In Dan Abnett's Gaunt's Ghosts novel The Guns of Tanith, Soric reveals that his great-grandmother was a witch, and that his father said it would come to him, as the seventh son of a seventh son. On the other hand, what it causes him doesn't seem very lucky at all...
- In Patricia C. Wrede's Frontier Magic, Lan is the seventh son of a seventh son, and so a natural magician. Others point out to Eff that she's a seventh daughter, even if she is a thirteenth child. The Always Male part of the trope is averted by the series, as double-seventh daughters are also magically gifted. It just takes a while for anyone to realize that the seventh daughter of a seventh son counts as a double-seven - all previously recorded double-sevens are seventh sons of seventh sons or seventh daughters of seventh daughters.
- In The Wardstone Chronicles, being the seventh son of a seventh son is literally a job requirement to be a spook.
- In Mercedes Lackey's Tales of the Five Hundred Kingdoms series, Sasha has some small magics, in part because he's a seventh son. Also, in One Good Knight, Gina mentions that three of her siblings have magical abilities.
"That kind of startled my parents, they had no idea that there was magic in their blood,but the sibs in question are the seventh born, the ninth born, and the thirteenth born, so that probably explains it."
- In The Secrets of the Immortal Nicholas Flamel, Perenelle Flamel is a female example. Being the seventh daughter of a seventh daughter allows one to speak to ghosts.
- In the Daughter of the Forest, the first book in the The Sevenwaters Trilogy:
- Sorcha is the seventh daughter of Lord Colum (himself a seventh son). Her six brothers are bound in a curse to be forever swans by her stepmother that only the seventh child can lift.
- Oonagh and Colum's son Ciarán is the seventh son of a seventh son. Even Sorcha herself comments on this when she hears about the birth.
- In The Secret of Platform 13, Odge the hag is the seventh daughter of a seventh daughter. Her mother was eagerly expecting what would surely be her most terrifying child yet, and was disappointed when she came out looking remarkably human, except for heterochromia, one blue tooth, and a small bump that hopefully will grow into an extra toe one day.
- In Susan Cooper's novel The Dark Is Rising, Will is the seventh son of a seventh son, and was born with a caul. He has a major role to play in the battle between the Light and the Dark.
- It doesn't come up as an important plot point in Harry Potter, but Word of God notes that Ginny being the seventh child in her family (albeit the first daughter) was supposed to symbolize her as someone special. She is also the first girl born into the Weasley family in several generations.
- A variant in the Piers Anthony novel Fractal Mode - Nona is the ninth born of the ninth generation, granting her the ability to have truer and stronger magic then other girls, and the potential to flip the magical patriarchy to a matriarchy. Which will flip again when there is born a male ninth of the ninth.
- A seventh son of a seventh son can allegedly see the torcs of Droods in the Secret Histories series. In Live and Let Drood, a seventh daughter of a seventh daughter proves she can, too.
- In The Balanced Sword, Tobimar Silverun is "Seventh of Seven", the seventh child of a seventh child; he completes a quest that his family has been unsuccessfully attempting for centuries, and in the process learns to unlock the power he's inherited from a divine ancestor.
Live Action TV
- The Doctor Who episode, "Terror of the Zygons" has a landlord who claims to have the power of second sight because he's the seventh son of a seventh son.
- In the Soap Opera Days of Our Lives, a shadowy crime lord called "The Phoenix" claims to be the seventh son of a seventh son and to have magical powers.
- In Charmed, a seventh son of a seventh son is revealed to be The Chosen One to defeat a powerfull witch, by using her own wand against her.
- In The Twilight Zone episode "Still Valley", a Confederate soldier met an old man who had magical powers because he was the seventh son of a seventh son. He also had a Deal with the Devil thing going on.
- In Highlander, the fortune teller mentions Duncan being this. The mystical part is probably in connection with his immortality.
- Willie Dixon's classic and much covered blues song, "Seventh Son" claims various powers for the singer.
- Led Zeppelin's song "Poor Tom" recounts a middle-aged laborer named Tom, who was the seventh son of a seventh son, and could see reality as it really is. This leads him to kill his promiscuous wife.
- Iron Maiden's album Seventh Son of a Seventh Son, and the title track, are all about this trope; the album was inspired by Orson Scott Card's novel, Seventh Son (see Literature).
- From The White Stripes' "Ball and Biscuit":
I might be your third man, girl
But it's a fact I'm the seventh son.
- In the tabletop role-playing game Changeling: The Lost, being the seventh son of a seventh son is one of the conditions that can help someone penetrate a Changeling's glamour.
- In Mage: The Awakening, "Magical Traditions" introduces Southern Conjure as a "flavor" which offers a special merit called "Seventh Son of a Seventh Son" that basically turns any mage into a walking, talking Fate Arcana magnet.
- The New World of Darkness book Skinchangers gives us the Lobison, an Argentinian werewolf story wherein the seventh child of a family, if a boy, will be cursed to change into a bloodthirsty wolf-creature when stressed. (In real life, the tale of the lobison led to so many children being abandoned or killed that the government had to step in.)