Ramona QuimbyThe main character. Energetic and inquisitive, Ramona is sometimes a handful for her parents and teachers, despite that she enjoys school (except spelling, since she finds it boring) and gets along with most of her class.
Beatrice "Beezus" QuimbyRamona's big sister, and the main character of Beezus and Ramona. She fights with her sister often, but they still get along for the most part, especially as Ramona got older.
Roberta QuimbyBorn at the end of Ramona Forever when Ramona was eight years old. She caused Ramona to develop a slight Middle Child Syndrome, though Ramona does enjoy playing with her and tries to get her parents to let her babysit.
Dorothy QuimbyRamona's mother. Originally a stay-at-home mom, she started working part time in Ramona the Brave to help the family make money and then full time in Ramona and her Father after her husband lost his job.
Robert QuimbyRamona's father and aspiring artist. He was laid off in Ramona and Her Father but got a job as a cashier at a supermarket. Frustrated with the stress of the job he went back to college to get his teaching certificate, however due to being unable to find work as a teacher, he returned to work at the supermarket as a manager.
Aunt BeatriceDorothy's younger sister and Beezus' favorite aunt. She's an important secondary character in Beezus and Ramona but doesn't show up again until Ramona Forever.
Picky-pickyThe family cat, who is several years older than Ramona. He dies during Ramona Forever.
Henry HugginsBeezus's friend, and star of his own series. He's an important character in Beezus and Ramona, and makes a few appearances in later Ramona books.
DavyA boy in Ramona's class. In kindergarten she thought he was cute and would chase him around trying to kiss him. He has trouble in school, and Ramona often tries to help him out.
The Kemp familyHowie, Willa Jean, their grandmother, and their Uncle Hobart. Howie is Ramona's friend throughout the series, though they start to drift apart as they get older. Willa Jean is Howie's younger sister and causes a lot of trouble (in fact, she acts just like Ramona did when she was four). Howie's grandmother spoils Willa Jean, but doesn't like Ramona, making her watch Willa Jean and then blaming Ramona whenever she does anything wrong. Uncle Hobart shows up in Ramona Forever and marries Aunt Bea before the two move to Alaska.
Susan KushnerA girl in Ramona's classes throughout the series, and one of the few that Ramona doesn't get along with. In kindergarten Ramona was obsessed with tugging on Susan's curls and yelling "boing!", but their full-blown animosity didn't start until first grade when Susan copied Ramona's art project and Ramona retaliated by destroying Susan's work. Ramona makes peace with her at the very end of Ramona's World when she realizes that Susan is only the way she is because of her mother.
Daisy KiddIntroduced in Ramona's World, she quickly becomes Ramona's best friend. Her family mirrors Ramona's in many ways, and Ramona thinks that Daisy is absolutely perfect.
Yard ApeA boy in Ramona's fourth grade class. Even though he starts out teasing her and stealing her eraser, they become friends and she quickly develops a crush on him.