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The first thing I said was that it was an Edutainment Game. So no, definitely not Futurama.
Yes, this troper did see that it was an Edutainment Game according to your message, but something does not seem to fit with it being an educational game. The description you provided makes it clear that the section you remember is a parody of 2001: A Space Oddyssey but it would not fit well in an educational game and there don't seem to be any that have a location meeting your description. The second part does not help all that much since that style of line appears in quite a few games but the first part is extremely distinctive, making it possible that you might have inadvertently combined two games.
Edited by Kevonni4Bump again. I may have been wrong about the "guide" being a frog, but I clearly recall hearing "Blue Danube" in the main hub of the game. It was edutainment, and I'm sure that this same game had the "reporting live from Springtown" line in it. Followed by something else that I can't actually remember.
Edited by thevisualboy37Well, now that I've figured out Learning Voyage and Mathosaurus by myself, and the book Not So Rotten Ralph thanks to another troper, I think I'm on a roll with these older posts so I'm gonna bump this one.
I just so happened to stumble across a list of Pop-Up Video Games (those games where you click on things and random stuff happens), and I think I may have found some stuff that will at least jog your memory:
Cosmic Osmo seems to fit your description well, except for the fact that the companion that follows you around is an alien and not a frog. He is green like a frog, so it's close enough.
This next one is on Windows, but it might have had some sort of Mac port or something. Kidspace from Packard Bell Navigator: https://m.youtube.com/watch?v=2QlLQJDOBlw
(Kidspace starts at about the 5:20 mark.)
Hope that helps!
Edited by GitarooHero Saving the world, one fret button at a time.Hmm. I never posted here once I finally figured it out. Once again, I was way off; it wasn't a frog, it was a green firefly with big eyes. I got confused between that and a big-eyed green frog from Kid Pix. This game was actually "Let's Pretend: Space is Our Playground!" and the line in question was, "This is Space Ant Joe, broadcasting live from Ringtown! We're be-boppin' with the cool cats down here at the Rockin' Rocket Café! Bring your steady for a 5-cent float and catch Our World is a Playground at the Fly-By-Night Drive-In!" (Our World is a Playground was the first game in the "Let's Pretend" series.)

This was an Edutainment Game I played in Kindergarten (around 1999 or 2000). I think it was on Mac. I can only remember two parts about it: in one, you're on a space station in zero-gravity, and if you click on something, Strauss' Blue Danube plays (recently figured this out). The other part is clicking on a radio transmitter will cause a guy to say "This is [I've forgotten the name, but it was something like "Big Bad Joe"] reporting live from Springtown!" and talk for a little while about... something. The name of this game has been bugging me for a long time. I also remember there being a guide, and I think it was a talking frog. Oh, and before you say Microsoft's Explorapedia: World of People, that's not it; I tried it, thinking that might be it, and it wasn't. I don't even think it's Mac-compatible, anyway.
Edited by thevisualboy37