Harsher in Hindsight: After Castiel's Love confession, it's hard to watch every one of his moments with Dean, especially the ones where they are at each other's throats, knowing that all this time Castiel has been in love with Dean.
People have relentlessly mocked the Bury Your Gays nature of the situation, with people referring to being taken to the Empty as going to "super ultra mega Hell" for not being straight.
"So you're telling me I had to learn about [x] from a Destiel post?" or similar statements. Explanation With the explosion of Destiel posts on Twitter and Tumblr, a lot of people ended up first hearing unrelated news items because they were referenced in a Destiel post, with (debunked) rumors about Vladimir Putin stepping down being the most famous example.
Destielputinelection.Explanation A parody of the Superwholock fandom, referring to how Destiel became canon and took over the internet on one of the most politically tense nights of the year (Day 3 of the U.S. Presidential election going without a winner being called, Georgia and Pennsylvania's vote counts coming within a fraction of a percentage point of flipping both states for Joe Biden, Donald Trump repeatedly lying about the election and trying to interfere with the vote-counting process, and the above-mentioned false rumors about Putin).
The most homophobic gay love confession possible. Explanation Between the Dull Surprise and Bury Your Gays mentioned above and Supernatural's long history of being accused of queerbaiting, people joked that the show somehow managed to make a romantic scene that was gay and homophobic at the same time. Dean in particular being homophobic is a common iteration.
"[x] is going to become canon (Spanish dub)." Explanation The South American dub for the episode has Dean respond to Cas' love confession with "y yo a ti, Cas", which translates to "And I you, Cas". Meaning that in the Spanish dub, Dean reciprocates Cas' feelings.
"In the [x] dub, Dean says..." Explanation After the Latin American dub aired, people began joking about how other dubs might alter Dean's reaction to the love confession, such as "In the Russian dub, Dean calls Cas a slur" or "In the cowboy dub, Dean says, 'I wish I knew how to quit you.' "
"Remember Remember the 5th of November"Explanation Tumblr has turned the day that the episode aired, into it's own special Holiday. Due to the craziness surrounding that night, that was mostly heralded by the Cas' love confession.