- California Doubling: Takes place in New England but was filmed New Brunswick, Canada.
- Colbert Bump: Children of a Lesser God received renewed attention and interest in 2022 following the success of CODA, which also stars Marlee Matlin and features similar themes about relationships between the deaf and the hearing. William Hurt coincidentally passing away at the same time that CODA was cleaning up at awards ceremonies may have been a contributing factor.
- Disabled Character, Disabled Actor: Marlee Matlin, who would become the first (and for 35 years, the only) deaf performer to win an Academy Award for her performance as Sarah.
- Romance on the Set: William Hurt and Marlee Matlin dated for a couple years afterwards. Matlin would later allege that Hurt was abusive to her and that the abuse began while they were still filming.
- Star-Making Role: For Marlee Matlin, while cementing William Hurt's status as a critical favorite.
Trivia / Children of a Lesser God