- The death of M-24. 'Nuff said. It's also accompanied by a detailed flashback of what M-21 and M-24 suffered through when being used as experimental material by the Union. Amazingly, it's treated as a happy memory, as M-21 remembers his bond with the other members of the M-series. Then we're treated to M-21 bawling his eyes out as he says that he doesn't want to loose M-24, and another flashback of M-24 saying that he thinks he might have had younger siblings before he became an experiment, and asking M-21 if he'd be OK with calling him by the Korean term for big brother.
- Shark is about to kill the children, one at a time. M-21 is having an internal debate with himself, saying that he only has to stand still and let it happen, and he'll be able to keep his promise to his deceased friends from the M program, complete with an image of them in his mind. He then apologizes for having to betray them before leaping in to save the children. And then he sees his dead friends smiling about his decision.
- Rai's entire existence. He's spent thousands of years living in isolation, the only special thing he had was to gaze out the window of his mansion. And then he finally gets to live in a world with friends and companions, and in less than a year he's already dying.
- The decision made by the RK after learning of Rai's circumstances - if ever a situation arises where Rai must use a lot of his power for them, they should simply die. Especially poignant in the case of the enhanced humans, who have only lived free from the control of the Union for a relatively short time.
- The deaths of Urokai and Zarga, where we get treated to a flashback where they always wanted to entertain and impress Rai.
Tear Jerker / Noblesse