"Derek...I'm sorry. Your mother and father...they're dead..."
- The death of Wheels' parents is, for all intents and purposes, the Tear Jerker moment for many, as not only is it an extremely traumatic turn of events, but it heralds his long and protracted downfall into Jerkass territory.
- Spike's looks of fear and despair in It's Late, knowing that her adolescence will never be the same again now that she is pregnant.
- Shane's entire story arc. Between his unsupportive parents and a strained relationship with Spike, he is kept out of Emma's life. And then while on acid, he falls from a bridge and is rendered permanently brain damaged for life.
