Following her meltdown in the last episode, Amy tries to relax using a deprivation tank. Unfortunately, the pressure of winning a Noble Prize gets to her. Meanwhile, Howard and Raj use a scooter to try and relive their single days.
- Call-Back: To the time Howard had a scooter.
- Guilt by Association Gag: Due to being Amy's husband, Sheldon ends up getting chewed out by President Siebert for her blowup.
- Hollywood Mid-Life Crisis: When Howard and Raj see a scooter for sale in "The Inspiration Deprivation", Howard purchases it so he and Raj can ride it together like they did when they were both younger and single. Too bad for him Bernadette makes him sell it once she finds out, arguing that it's too dangerous. Howard then sells the scooter to Bert late in the episode.
- Reality Ensues: After Amy explodes at Dr. Pembleton and Dr. Campbell, she and Sheldon are forced to do damage control by the university in order to not lose their chances at winning a Nobel. They also have to apologize to Pembleton and Campbell.