Buddy could use an aspirin.
Grant Morrison
- The ape-blob thing that closes issue 1, with tendrils and tooth and slime leaking out of it.
- Issue 2 ends with a classic one: The rat-human hybrid slices Buddy's arm and leaves him to bleed on an alley. He gets better though.
- In general, the Evil Poacher subplot from the first arc: A bunch of illegal hunters who kill animals for the sport and almost rape Ellen.
- The final fate of Myers: Fused with a gorilla and left to be experimented on by his peers. He was a Jerkass but you can't help feeling pity for the poor bastard.
- Crafty the Coyote's grotesque and highly detailed resurrections. He himself looks very uncanny.
- The dolphin massacre in the Faroe Islands. The children play with the fetuses. It's even worse because it was sadly a thing that still happens.
- Issue 17's cover: A baby ape with its eyes stitched.
- Overman is a Homelander-esque Superman from another Earth created by a government experiment who went mad with an STD and destroyed his world with a nuclear weapon.
Peter Milligan
- They might have been assholes, but the Angel Mob's final fate as lab rats is horrible, and a Moral Event Horizon for President Eagleton.
Tom Veitch
- Tom Veitch's run opens with a disturbing premise: Whenever Buddy goes, he finds dead bold eagles.
- The truth is even worse: He is killing animals he is absorbing his powers from. This is exemplified when he is absorbing the powers of animals at the San Diego Zoo and accidentally kills all of them.
- The final villain of Veitch's run is the Antagon, the sentient dark side of the morphogenetic field that only wishes for the death of animals. Sealed 10000000000 years ago by the Animal Masters, it was then forced into a cocoon which Stone and a recently empowered Buddy tried to destroy but it was too strong. Emerging on the early nineties, it first caused A-Man's powers to malfunction and it later possessed ex-superhero B'wanna Beast and recquired the strength of all the Animal Masters and avatars of the Red to finally thwart it.
Jeff Lemire.
- The "New 52" reboot has plenty. Considering that the main antagonists are beings known as the "Rotten" that take the appearance of Eldritch Abominations that can inflict a lot of Body Horror on people. Even the main characters are not immune to these effects.
