In real life, sai are very rarely actually bladed weapons, and are primarily used in defense in order to disarm and/or break blades. In fiction, however, the middle prong (or all three) is usually sharpened into a makeshift dagger. (Sometimes Truth in Television, but not normal practice.) Unusually, Dual Wielding a pair of sai is Truth in Television. The common depiction of turning them into a punch-dagger type weapon with the middle prong held between the middle and ring finger decidedly is not Truth in Television, as it would be an absurdly useless way to wield a sai.
- Elektra's Weapon of Choice in the Daredevil comics.
- Deadpool sometimes uses these.
- One of the preferred weapons of Zaran the Weapons Master in the Marvel Universe.
- Teenage Mutant Ninja Turtles: Raphael's Weapon of Choice in almost every version is a pair of sai. Teenage Mutant Ninja Turtles (2012) is the first where he uses them as intended, as a grappling/disarming weapon, rather then as a stabbing dagger.
- The Mummy Returns: A Flashback has a duel between two women Dual Wielding these, which doesn't make sense as sais originated from Asia, not Egypt. And more specifically, sai were a rice-agricultural implement, and the Nile has always been primarily wheat territory.
- The Matrix Reloaded: Neo used his powers to pull two sais off the wall and fight with them during his battle with the Merovingian's minions. He ends up using them to pin one of his assailants to the wall.
- Xena: Warrior Princess's sidekick Gabrielle makes a point of fighting principally with a pair of Sai, starting in Season 5 and lasting until the end of the show. The exclusivity of the weapon to Gabrielle made them all the more cool.
- Deadliest Warrior: the Yakuza used Sais as a weapon.
- Mele / Camille.
- Used by Vetkin in Battle Realms.
- Mileena from the Mortal Kombat series fights using a pair of sai.
- Guild Wars, starting with Factions, has sais as a type of dagger for the Assassin profession.
- AdventureQuest Worlds also uses them as daggers, the one kind of weapon that can be dual-wielded. They're quite popular with Ninjas.
- Wang Yi from Dynasty Warriors 7: XL.
- Monsoon from Metal Gear Rising: Revengeance.