- Del Griffith's declaration that he knows what kind of person he is, and he's not going to change. It's clearly John Candy himself talking as much as the character, and easily the most moving scene of his far too short career.
- After Neal's long profanity-filled rant, the clerk (Edie McClurg) calmly asks him if he has his rental receipt. His response? "I threw it away." Her response? "You're fucked."
- A Real Life example, both Martin and Candy regarded their performances in this film as the best of their respective careers.
Awesome / Planes, Trains and Automobiles