History Main / MasterPoisoner

* Sucy of ''Anime/LittleWitchAcademia'' is supposedly a general potions specialist, but all we really see her do is make poisons. And she is ''very'' good at it; in [[Anime/LittleWitchAcademia2013 the OVA]], one of her concoctions turned it's victim to into [[ImMelting a pile of goo]], which then melted through the solid stone floor!

* The Assassins in ''Literature/{{Journey}}'' are very good at this. Also, Ruen concocts poisons for his sister to use.

* The Silent from ''VideoGame/SlayTheSpire'' has this as her modus operandi, if she isn't [[KnifeNut shivving her enemies to death]]. She can summon poison clouds, use PoisonedWeapons, or throw flasks with lethal poison. She can even double or triple the poison's effectiveness if her poisons don't work fast enough.

* ''LightNovel/BeastTamerAndTheCatGirl'': A common tactic Rain uses is the contracting of poisonous creatures to subdue enemies. He has a thorough knowledge of which animals can do what, as he uses different poisonous beasts each time he uses this trick. Against Tania he used poisonous ravens he detected in the area, against the Jet-Black Fangs and Arios he used bees, and when rounding up corrupt guardsmen he incapacitated them by trapping them in an enclosed area into which he sent butterflies with paralyzing poison scales. In the last case Rain and company can watch from the area's upper floors because he's aware of the scales being heavier than air.

A Master Poisoner is a character who is an expert in the preparation and administering of poisons. He can tailor a toxin to any situation: to paralyse, to knock out, to kill, or even other, more exotic, effects that others would consider beyond the realms of conventional toxicology.

* ''Franchise/{{Batman}}'':
** This was ComicBook/PoisonIvy's original shtick in the ''Franchise/{{Batman}}'' comics, before she became a PoisonousPerson.
** Another ''Batman'' villain, ComicBook/TheJoker, was a prodigy at this. In both the [[Film/Batman1989 1989 movie]] and the [[WesternAnimation/BatmanTheAnimatedSeries animated series]], he developed "binary compounds" by which he could succeed in murdering victims with the ''second'' exposure, thus appearing not to have been directly responsible for their deaths. The man's chemistry skill is such he can create incredibly toxic compounds out of nothing but the contents of a janitor's closet.
** Yet '''another''' ''Batman'' villain, ComicBook/TheScarecrow, concocts fear toxins to give targets nightmarish hallucinations.

** ComicBook/RasAlGhul's [[Characters/BatmanLeagueOfAssassins League of Assassins]] generally keeps a few in its employ, most commonly [[Characters/TeenTitansCheshire Cheshire]] who keeps her weapons drenched in poisons. Other poisoners associated with the League include "Viper", a non-combatant whose entire job revolved around creating new poisons and whose concoctions once nearly killed Ben Turner before he came up with the code-name Bronze Tiger.
** ''ComicBook/RedHood'': Poison is listed as one of his specialties, and he was able to showcase this in ''ComicBook/GrantMorrisonsBatman'' where he secretly poisoned a prison cafeteria, killing 82 and others severely ill.
** ''Comicbook/RedRobin'': Funnel of the Council of Spiders takes pride in creating quick-acting incredibly painful poisons, and is insulted by other poison using murderers whose poisons don't fit what she thinks a perfect poison should be or are "boring".

* ''Franchise/TeenTitans'' rogue [[Characters/TeenTitansCheshire Cheshire]] is considered as one of the greatest poison experts in the ''Franchise/DCUniverse'', possessing a vast amount of knowledge about chemicals and toxins, to the point she has created some positively awful concoctions to unleash upon her opponents while also making them [[PerfectPoison almost undetectable]] and has [[AcquiredPoisonImmunity made herself immune to most of them]]. Most of her weaponry is also [[PoisonedWeapons coated in poisons]] making a [[DeadlyScratch single scratch being extremely deadly.]]

* ''Series/{{Millennium}}'': Art Nesbitt in "Loin Like a Hunting Flame", who's picked up his skills through his legit job as a pharmacist. He is a killer driven by sexual neuroses and who uses mood-altering drugs to gain control of his victims.

** This was Poison Ivy's original shtick in the ''Franchise/{{Batman}}'' comics, before she became a Poisonous Person.

** Yet '''another''' ''Batman'' villain, Scarecrow, concocts fear toxins to give targets nightmarish hallucinations.

* ComicBook/RasAlGhul's League of Assassins generally keeps a few in its employ, most commonly Cheshire who keeps her weapons drenched in poisons. Other poisoners associated with the League include "Viper", a non-combatant whose entire job revolved around creating new poisons and whose concoctions once nearly killed Ben Turner before he came up with the code-name Bronze Tiger.
* ''ComicBook/RedHood'': Poison is listed as one of his specialties, and he was able to showcase this in ''ComicBook/GrantMorrisonsBatman'' where he secretly poisoned a prison cafeteria, killing 82 and others severely ill.
* ''Comicbook/RedRobin'': Funnel of the Council of Spiders takes pride in creating quick-acting incredibly painful poisons, and is insulted by other poison using murderers whose poisons don't fit what she thinks a perfect poison should be or are "boring".

* ''WesternAnimation/CarmenSandiego'': Lady Dokuso (who's name means [[MeaningfulName Lady Poison]]), a member of V.I.L.E, is one of these. She has a masterful knowledge of all kinds of poison and is capable of using any numbers of means to introduce poisons to her targets, from darts and blades, to innocuous things like chopsticks.

** A Master Alchemist in ''[[VideoGame/TheElderScrollsIVOblivion Oblivion]]'' can produce a staggering variety of poisons with StandardStatusEffects beyond all those listed in the trope definition. Though poisons in-game aren't as instantly lethal, a full stack of damage-over-time effects make it a foregone conclusion. Replace one of those with fatigue-drainer, and you can safely look your opponent in the eye as it dies.

* Alfyn Greengrass from ''VideoGame/OctopathTraveler'' is primarily a [[TheMedic healer]] who just wants to help people, but is certainly capable of using his knowledge as an apothecary to inflict harm when needed. One of his class skills, Empoison, always succeeds if the target is vulnerable to poison--and the vast majority of enemies, including most chapter bosses and ''several of the setting's gods'', are. He can also mix items to Concoct harmful powders that have a chance of inflicting various StandardStatusEffects, including poison, to the whole enemy team. In story, he carries a plant called ''slumberthorn'' whose toxin not only pulls the victim into a deep sleep but [[spoiler: plagues the victim with horrifying nightmares if they have any evil deeds weighing on their conscience. He uses this to subdue and partially reform the Chapter 2 boss after their battle.]]

* In ''TabletopGame/{{Pathfinder}}'', a number of classes such as rogues, assassins, and the currently experimental ninjas are proficient poisoners, but it's the [[TheRedMage Alchemist]], which can not only make poisons but becomes completely immune to them, can refine them into a more deadly, harder to resist form, make them last longer on the weapon and make them in a fraction of the time with reduced material costs.

* In the ''D&D'' lawyer-friendly spinoff ''TabletopGame/{{Pathfinder}}'', a number of classes such as rogues, assassins, and the currently experimental ninjas are proficient poisoners, but it's the [[TheRedMage Alchemist]], which can not only make poisons but becomes completely immune to them, can refine them into a more deadly, harder to resist form, make them last longer on the weapon and make them in a fraction of the time with reduced material costs.

* ''ComicBook/SonicTheHedgehogArchieComics'': Patch, Antoine's MirrorUniverse [[EvilTwin counterpart]], was revealed to be this during the time he impersonated Antoine on Mobius Prime in a bid to take over the Kingdom of Acorn. To this end, he poisoned both King Max and Antoine's father using a toxin native to his own dimension, with Dr. Quack being unable to pinpoint the cause of their deteriorating health until after Patch was exposed. By that point, however, the damage is done; Max is left wheelchair-bound once again, and Armand, who was given much heavier doses thanks to Patch [[TamperingWithFoodAndDrink lacing his food with it]], ends up dying in the hospital.

* In ''Franchise/{{Dune}}'' poison is almost an accepted science.
** Definitely a favorite (after the Hormu kick) of the Honored Matres in ''Literature/ChapterhouseDune''.

* ''Literature/TheMalloreon'': First introduced as a reluctant antagonist in the ''Literature/{{Belgariad}}'', Sadi is shown to be exemplary even by Nyissan standards especially after becoming a protagonist. He has an encyclopaedic knowledge of, and incredible skill at, pharmacology, drug-dealing, and anything related to potions and chemicals in general. He is creative, clever and wily, able to weaponise almost any chemical concoction, favouring PoisonedWeapons, and is a rare fictional example of a truly badass eunuch. Garion's page quote is NotHyperbole, as Sadi eventually proves through some excellent people-watching skills and a [[CleanFoodPoisonedFork poisoned spoon]].

* In ''Literature/TheCountOfMonteCristo'', the poisoner Madame de Villefort is frequently compared to Locusta (see RealLife examples below).

* Newsuit Nan in ''ComicStrip/DickTracy''. She was a chemist who specilised in the creation of blood-based toxins which she would use in poisoned nail polish and inject into her victims by scracthing them with her FemmeFatalons. Her creations included an instantly fatal poison; a 100% reliable TruthSerum; and a poison that sapped the target's free will, making them a puppet.

* This was Poison Ivy's original shtick in the ''Franchise/{{Batman}}'' comics, before she became a Poisonous Person.

** Professional hitman Somg specializes in poisoning people. He is obsessed with a quality of his poisons and makes all of them himself, in his own laboratory. On top of regular poisons, he is able to create deadly artificial viruses and can tailor their effects for various situations - [[spoiler:like a virus that makes target appear seriously sick, but becomes inactive after a few hours, leaving only minor damage.]] His talents work even beyond the poisons - for example, he creates highly effective nutrients.

** Professional hitman Somg specializes in poisoning people. He is obsessed with a quality of his poisons and makes all of them himself, in his own laboratory. On top of regular poisons, he is able to create deadly artificial viruses and can tailor their effects for various situations - [[spoiler:like virus, that makes target appear seriously sick, but becomes inactive after a few hours, leaving only minor damage.]] His talents work even beyond the poisons - for example, he creates highly effective nutrients.

* ''ComicBook/ArchieComicsSonicTheHedgehog'': Patch, Antoine's MirrorUniverse [[EvilTwin counterpart]], was revealed to be this during the time he impersonated Antoine on Mobius Prime in a bid to take over the Kingdom of Acorn. To this end, he poisoned both King Max and Antoine's father using a toxin native to his own dimension, with Dr. Quack being unable to pinpoint the cause of their deteriorating health until after Patch was exposed. By that point, however, the damage is done; Max is left wheelchair-bound once again, and Armand, who was given much heavier doses thanks to Patch [[TamperingWithFoodAndDrink lacing his food with it]], ends up dying in the hospital.

* French movie ''Film/LeCapitan'': In 17th century France, conspirators are shown using the services of an expert poison-maker who's a DepravedDwarf. When asked where his deadly talent is coming from, he answers "Nature has played a mean trick on me. I'm not done paying it back."

*** The [[PrivateMilitaryContractors Dogs of War]] special character Lecrezzia Belladonna[[note]]a ShoutOut to the [[DatedHistory traditional view]] of Lucrezia Borgia[[/note]] is the most beautiful woman in Tilea [[BlackWidow whose husbands have a tendency to die]] from poisoning soon after making a mistake. In-game Lecrezzia has a number of special rules and items involving poisons, such as poisoned weapons and the Phial of Poison that can be used on enemy characters before a battle.