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* ''Webcomic/ImTheGrimReaper'': Scarlet’s comes very early in the story. At first she’s more apprehensive about killing sinners, but when the seemingly nice young man she meets who’s marked as one turns out to be a cold blooded serial killer, she quickly becomes more jaded and willing to do the job.

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* ''Webcomic/ImTheGrimReaper'': Scarlet’s comes very early in the story. At first she’s more apprehensive about killing sinners, but when the seemingly nice young man she meets who’s marked as one turns out to be a cold blooded serial killer, she quickly becomes more jaded and willing to do the job.


* Leon Oswald from ''Anime/KaleidoStar'' has a dead little sister. Her name was Sophie, she was [[BrotherSisterTeam his partner]] as well, and was killed in a car accident before a big competition ''in front of Leon himself''. He [[MyGreatestFailure still blames himself]], and is always [[ReplacementGoldfish looking for someone like Sophie]] ([[FamilyUnfriendlyAesop to a pretty destructive extreme]]), which leads him to main girl Sora Naegino.

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* Leon Oswald from ''Anime/KaleidoStar'' has a dead little sister. Her name was Sophie, she was [[BrotherSisterTeam his partner]] as well, and was killed in a car accident before a big competition ''in front of Leon himself''. He [[MyGreatestFailure still blames himself]], and is always [[ReplacementGoldfish looking for someone like Sophie]] ([[FamilyUnfriendlyAesop to a pretty destructive extreme]]), extreme), which leads him to main girl Sora Naegino.

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* ''{{Film/Clara}}'': It's revealed that the source of Isaac's bitterness was his infant. Though not explicit, it's implied this is why he's an atheist and sees no meaning in the universe.


* ''Franchise/ShinMegamiTenseiPersona'':

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* ''Franchise/ShinMegamiTenseiPersona'':''Franchise/{{Persona}}'':

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* In ''VisualNovel/ShinraiBrokenBeyondDespair'', this is zig-zagged with Raiko when it comes to [[spoiler:her sister's death]], [[ItsAllMyFault a tragedy she believes is her fault]]. On the one hand, Raiko became more gloomy after the event in question, as her parents [[spoiler:and Kamen, who met Raiko shortly before the incident]], can attest to. On the other hand, [[TheAtoner Raiko resolved to become a better person to make up for the guilt of letting such a thing happen]].





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** From the same series, [[spoiler: Luke Castellan]] was a pretty normal kid [[spoiler: even accounting for his mom who went crazy trying to become the Oracle and rambled off about his inevitable terrible fate]], but then he had to watch a good friend's sacrifice. [[spoiler: This solidified his belief that the gods don't care and caused him to side with Kronos.]]

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* Before Kyle Rayner leaves Earth after being traumatized by the brutal hate crime inflicted on his gay assistant Terry, he tells his then-girlfriend Jade (Jennifer-Lynn Hayden, daughter of the first Green Lantern) about his insights into the human psyche during his time as Ion, and what they revealed to him about man's inhumanity to man, which unfortunately is still true today:
--> '''Kyle Rayner:''' Jen, I can't do this anymore.
--> '''Jen:''' Do what?
--> '''Kyle Rayner:''' Protect Earth. I've been thinking about something Brainwave said a few months back. About what drove him insane. He said that he had reached into the minds of millions, and all he found was hate. When I was Ion I felt it, too. Jen, there is good in this world, but it doesn't measure up to the bad. In the hearts of humanity, there is anger, there is rape, there is brutality... there is hate. It took this happening to Terry to... ...to break me. I can't help these people now. I don't want to. Earth will have to get by without me.
--> ''Green Lantern #155 (2002)''


* ''Disney/BigHero6'': [[spoiler:Professor Callahan became the villain Yokai to avenge his daughter, who was enveloped in a malfunctioning experiment of Allstair Krei, whom he held responsible for it.]]

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* ''Disney/BigHero6'': ''WesternAnimation/BigHero6'': [[spoiler:Professor Callahan became the villain Yokai to avenge his daughter, who was enveloped in a malfunctioning experiment of Allstair Krei, whom he held responsible for it.]]


* ''Series/StarTrekPicard'' opens with the reveal that [[Film/StarTrek2009 Nero]] was right to blame the Federation as this is why [[Series/StarTrekTheNextGeneration Picard]] left Starfleet: The Federation really did leave the Romulans to die and Picard was so disgusted he resigned.[[note]]This was a case of ThreatBackfire as Picard threatened to resign if Starfleet didn't help -- and they accepted his resignation[[/note]]

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* ''Series/StarTrekPicard'' opens with the reveal that [[Film/StarTrek2009 Nero]] [[VillainHasAPoint was right to blame the Federation Federation]] as this is why [[Series/StarTrekTheNextGeneration Picard]] left Starfleet: The Federation really did leave the Romulans to die and Picard was so disgusted he resigned.[[note]]This was a case of ThreatBackfire as Picard threatened to resign if Starfleet didn't help -- and they accepted his resignation[[/note]]


* In ''Film/RevengeOfTheSith'', the ''fear'' of the loss of Padmé Amidala [[DeathByChildbirth by childbirth]] is what drives Anakin Skywalker over the edge to TheDarkSide. Before that, there was the death of his mother in ''Film/AttackOfTheClones'' which started his descent. For extra irony, she dies from childbirth because she loses her desire to live after seeing the monster Anakin becomes in trying to prevent her death.

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* In ''Film/RevengeOfTheSith'', the ''fear'' of the loss of Padmé Amidala [[DeathByChildbirth by childbirth]] is what drives Anakin Skywalker over the edge to TheDarkSide. Before that, there was the death of his mother in ''Film/AttackOfTheClones'' which started his descent. For extra irony, [[SelfFulfillingProphecy she dies from childbirth because she loses her desire to live after seeing the monster Anakin becomes in trying to prevent her death.death]].


* ''Series/StarTrekPicard'' opens with the reveal that [[Film/StarTrek2009 Nero]] was right to blame the Federation as this is why [[Series/StarTrekTheNextGeneration Picard]] left Starfleet: The Federation really did leave the Romulans to die and Picard was so disgusted the resigned.[[note]]This was a case of ThreatBackfire as Picard threatened to resign if Starfleet didn't help -- the they accepted his resignation[[/note]]

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* ''Series/StarTrekPicard'' opens with the reveal that [[Film/StarTrek2009 Nero]] was right to blame the Federation as this is why [[Series/StarTrekTheNextGeneration Picard]] left Starfleet: The Federation really did leave the Romulans to die and Picard was so disgusted the he resigned.[[note]]This was a case of ThreatBackfire as Picard threatened to resign if Starfleet didn't help -- the and they accepted his resignation[[/note]]


* Ho from ''Webcomic/TowerOfGod'' feels guilty for not being strong enough to protect his friends from a berserk stray warrior. It has made him rather jealous and loathing towards anyone with greater power than him, especially Bam.

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* Ho Hoh from ''Webcomic/TowerOfGod'' feels guilty for not being strong enough to protect his friends from a berserk stray warrior. It has made him rather jealous and loathing towards anyone with greater power than him, especially Bam.

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* Ogen, an apothecary and one of the supporting characters in ''VideoGame/OctopathTraveler'', used to be a WideEyedIdealist who would treat anyone without question, [[spoiler:until one of his patients, after receiving his life-saving medical treatment, murdered [[TheLostLenore his late wife]], causing him to become TheCynic he's now known in-game. Seeing his late wife's murderer with a family of his own when Ogen tracked him down only served to exacerbate Ogen further, to the point that he snapped and killed the man using the same method said man murdered Ogen's wife.]] His cynicism has stayed with him -- in fact, he outright states "Some lives are [[BeyondRedemption not worth saving]]."

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