History HalfHumanHybrid / AnimeAndManga

** In anime later the half-demon Izumo/Gyu-oh appears. His father was a temple monk, and his mother was a bull demon.
** The film ''InuYasha:FireOnTheMysticIsland'' is an island off the coast of Japan, in which once lived together peacefully many demons and humans, and also had many half-demons as children. In the film the last six surviving half-demons be saved from four very strong and very vicious demons.
** Some half-demons are not born as such, but were originally humans who are voluntarily merged with "lesser demons". The Big Bad Naraku has arisen in this way, and in the anime, we see that even with the dark priestess Tsubaki and the princess Sara Asano.

** The film ''InuYasha:FireontheMysticIsland'' is an island off the coast of Japan, in which once lived together peacefully many demons and humans, and also had many half-demons as children. In the film the last six surviving half-demons be saved from four very strong and very vicious demons.

* At the end of the manga of ''SpiceandWolf'' the wolf goddess Horo from the human Lawrence is pregnant.

* ''Manga/DragonHalf'' has the heroine Mink, whose mother was a dragon and whose father was a (human) dragon hunter. And Princess Vina whose father was a king, and whose mother was a slime (similar to those in ''VideoGame/DragonQuest'').

* According to ''PokemonSpecial'', Mewtwo was partially augmented with human DNA.

* In ''{{Sekirei}}'', it is revealed that [[spoiler: Minato and the other Ashikabi are essentially this because their ancestors were Sekirei that mated with humans in ancient times. Their alien heritage is expressed to a degree that they've been described as something other than human, but lack a Sekirei's core or powers.]]

* In ''Manga/TokyoGhoul'', One-Eyed Ghouls are said to be half-human and half-Ghoul. Protagonist Kaneki Ken becomes one after an organ transplant, and learns that others may exist as well. The legendary One-Eyed Owl is rumored to be a naturally-occurring hybrid, though this is the stuff of urban legend in the Ghoul community. However, these hybrids are noted to be more powerful than ordinary Ghouls and are invisible to the RC scanners the [[TheHunter CCG]] uses to detect Ghouls. Their name comes from the fact their GameFace only has one [[BlackEyesOfEvil Kakugan]], as opposed to both eyes changing.

* ''Manga/DragonHalf'' has the heroine Mink, whose mother was a dragon and whose father was a (human) dragon hunter. And Princess Vina whose father was a king, and whose mother was a slime (similar to those in DragonQuest).

* Both Averted & Justified in Creator/OsamuTezuka's ''{{Phoenix}}'' series, where there is only one species capable of breeding with others, the Moopies, who are able to do this due to VoluntaryShapeshifting (which is a completely different scientific impossibility, but what the hey).

* The manga version of ''ChronoCrusade'':

* The Crow special agents in ''DGrayMan'' are half-human and half-akuma - they're akuma enough to set off [[CursedWithAwesome Allen's eye]], but human enough to not actually be seen with it. Exactly how they got that way has yet to be revealed, but Black Religious Order experimentation by their Chief is a big part of it.

** Additionally, some of the background material state that Mikhail is part-Zentraedi and/or Zolan (as mentioned in the ''7'' section, the franchise seems to have retconned away the original reproductive incompatibility between Zolans and humans).

*** Averted, however, by the Zolans. Despite the Protoculture also messing with their evolution in the distant past and making them look very much like humans as a result, the Zolan are evolved from marsupials and their reproductive system is incompatible with humans and Zentraedi (which is the subject of some tension in an InterspeciesRomance radio drama in-universe). Whether they are ''still'' marsupials is rather unclear: the only unclothed female we see does not have an obvious pouch, and had not entered puberty yet anyway.

** ''Anime/MacrossDelta'' gives us another 2nd generation part-Zentran character in Mirage Fallyna Jenius, the granddaughter of Max and Millia (and Mylene's niece). Again, as with Ranka this goes to show how much mixed heritage is that big a deal now at this point in the timeline.

** ''Anime/MacrossDelta'' gives us another quarter-Zentran character in Mirage Fallyna Jenius, the granddaughter of Max and Millia (and Mylene's niece).

* ''Anime/SuperDimensionFortressMacross'' is certainly full of these, usually Zentraedi/Human hybrids. {{Justified|Trope}} in that the entire premise of the show is that Zentraedi and humans are two genetically modified offshoots of the same species.
** The original was baby Komillia ("little Millia", after one of her mother's [[SpellMyNameWithAnS various romanized name spellings]]).
** In ''Macross 7'', we meet Mylene, the series's GenkiGirl, who is naturally also a hybrid (Komillia's little sister, at that). In fact, when they discover an ancient ([[RagnarokProofing yet remarkably still functional]]) ruin, it's Mylene's hybrid nature that unlocks the final chamber, allowing the ruin's computer to see that the different races had stopped fighting and had children together.
** In TheMovie to the same series, we meet Mylene's ''other'' older sister Emillia, though their relation is only confirmed by a few seconds of dialogue.
** Official material has confirmed that there are actually four MORE sisters never seen in the series. Max and Miriya apparently REALLY hit it off.
** By ''Anime/MacrossFrontier'', we have at least one character who is ''quarter'' Zentran, as enough time has passed for grandchildren of the original Zentraedi defectors to begin to reach maturity, and there are mixed-heritage folks running around all over the place.
** Averted, however, by the Zolans. Despite the Protoculture also messing with their evolution in the distant past and looking very much like humans as a result, they are evolved from marsupials and their reproductive system is incompatible with humans and Zentraedi (which is the subject of some tension in an InterspeciesRomance radio drama in-universe). Whether they are ''still'' marsupials is rather unclear: the only unclothed female we see does not have an obvious pouch, and had not entered puberty yet anyway.
** Finally, the character of Ranka Lee (quarter-Zentran) is also revealed [[spoiler:to have psychic Vajra bacteria in her digestive tract. This is what allows her to communicate with the Vajra, and causes them to see her as one of their own. Notably, other humans/Zentraedi have been infected with this bacteria, but Ranka is the only person to have ever achieved symbiosis with it, apparently due to contracting it ''in utero''; everyone else was killed.]]

* Everyone except the hero in ''{{Utawarerumono}}'' has a varying combination of wings, long furry ears, and tails. It is revealed in the end that [[spoiler:they're all descendants of genetically engineered research experiments who escaped shortly before [[AllThereInTheManual the end of mankind]]. Despite having only minimal animal features, they were on the level of lab rats and dissected for research.]]
* In ''VoltesV'', [[spoiler: the Go/[[CulturalTranslation Armstrong]] brothers]] are revealed to be half-Boazanian.

* ''DragonHalf'' has the heroine Mink, whose mother was a dragon and whose father was a (human) dragon hunter. And Princess Vina whose father was a king, and whose mother was a slime (similar to those in DragonQuest).

* Gohan, Trunks, Goten and Bulla from ''Anime/DragonBallZ'' were half-Saiyans, an alien race. Even though humans and Saiyans are not the same species and seem to share no relation, they are capable of producing fertile offspring: Gohan has a quarter-Saiyan daughter named Pan, and Pan has at least one child and one grandson. Furthermore, while humans are much weaker then saiyans, taking much longer to train up to the same power levels, and have a lower strength cap, Saiyan/Human bybrid are exceptionally strong for some reason. All of the male hybrid characters gained power extremely rapidly and attained the Super Saiyan forms as children, and Gohan was the first character ever to reach the level of Super Saiyan 2 and by the end of the series was the most powerful (unfused) being in the universe by a long shot.

* In ''NagasareteAirantou'', we have Michiru. Her father is human while her mother is a [[{{Youkai}} Yuki-onna]].

* In ''SaintBeast'', brothers Kira and Maya are half-angel (their father) and half-human (their mother) and suffer FantasticRacism as a result.

* ''SilverDiamond'' has Chigusa: half-man, half-plant. Which apparently makes you damn near immortal. [[spoiler: Apparently, it's a family trait of the Senroh clan, earning them the title of Immortal Monsters.]]

* ''Anime/SuperDimensionFortressMacross'' is certainly full of these, usually Zentraedi/Human hybrids. [[JustifiedTrope Justified]] in that the entire premise of the show is that Zentraedi and humans are two genetically modified offshoots of the same species.

* ''{{Shuffle}}'' involves two extra humanoid races, the Gods and Demons... and hybrids will happen.

* ''{{Slayers}}'' has Zelgadis, an artificial example of this trope. He was born pure human, but was merged with a Blow Demon (a kind of Astral Goblin) and a stone {{Golem}} through the magic of Rezo, the Red Priest. This gives him pointed ears, blue skin, purple/lavender hair, patches of pebble-like "growths" all over his body, and either skin or flesh of solid rock.

* Being a ''TabletopGame/DungeonsAndDragons'' {{expy}}, ''RecordOfLodossWar'' has a few of these, the most traditional of these being Leaf, the Shaman from the Chronicles of the Heroic Knight TV series. Being Half Human and Half Elven, she is correctly referred to as a Half-Elf.

* This seems to happen a lot in ''OnePiece''. There are several variations between common species, including but not limited to; Humans, [[FishPeople Mermen, Fishmen,]] and Giants. And since One Piece usually adheres to the RuleOfCool most hybrids get strengths of both parents' species with few, if any, of the relative weaknesses.

* In {{Manga/Green Worldz}}, there are humans with different forms and abilities that are hunting humans down for reasons of their own. They are literally just refered to as "Hybrid humans". Few info is known about them except they are [[FromASingleCell near impossible to kill through conventional means]] and [[RunOrDie avoiding them would be a priority for survival]]. Even {{Bad Ass}} Iwatobi who [[spoiler: time traveled from 30 years of the future]] could not come up with easy tips to deal with them.

* Both Averted & Justified in OsamuTezuka's ''{{Phoenix}}'' series, where there is only one species capable of breeding with others, the Moopies, who are able to do this due to VoluntaryShapeshifting (which is a completely different scientific impossibility, but what the hey).

* In ''NagasareteAirantou'', we have [[WhoIsThisGuyAgain Michiru]]. Her father is human while her mother is a [[{{Youkai}} Yuki-onna]].

* In a cyberpunk, non-DNA variant, the original ''GhostInTheShell'' movie ended with Kusanagi merging with the Puppet Master's formless entity to become something else entirely.

* The Arume in ''BlueDrop'' regularly have offspring with earth women -- which takes some help from technology, since they are [[OneGenderRace all female themselves]].

* In the manga/anime ''{{Claymore}}'', the heroes are a sect of all female half-human, half-''youma'' who hunt full ''youma'', although [[spoiler:the main heroine Clare is actually only a quarter youma]]. A fallen Claymore warrior is called an "Awakened One" and is far ''more'' powerful than a pure-blooded ''youma''.\\

* ''[[Anime/JungleWaItsumoHaleNochiGuu Guu]]'' is a half human, half HumanoidAbomination. She's a mix between Merlin and Loki (but maybe that's just with Haré). To everyone else, she's just a CreepyChild, and they don't seem to mind. They just think she's a little odd, but nothing to worry about.