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* The Tuffle race in ''Manga/DragonBall'' is wiped out by the Saiyans who become giant apes at the full moon. They work under Frieza's planet trade to do this as a career choice.
** Also done when Buu unleashes a BeamSpam of epic proportions from the Lookout and kills every human '''NOT''' on the Lookout, [[ForTheEvulz just because he could]]. He later went and killed the few remaining people that were ''on'' the Lookout by turning them into food and eating them.

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* ''Franchise/DragonBall'':
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The Tuffle race in ''Manga/DragonBall'' ''Anime/DragonBallZ'' is wiped out by the Saiyans who become giant apes at the full moon. They work under Frieza's planet trade to do this as a career choice.
** Also done in ''Z'' when Buu unleashes a BeamSpam of epic proportions from the Lookout and kills every human '''NOT''' on the Lookout, [[ForTheEvulz just because he could]]. He later went and killed the few remaining people that were ''on'' the Lookout by turning them into food and eating them.

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* ''VideoGame/{{Spore}}'': The Grox are fatally allergic to the combination of gases that most other species refer to as 'breathable air'. [[HostileTerraforming Terraforming one of their planets to a level others would consider 'livable']] causes every Grox on the surface to choke to death.


* This is the BigBad's goal in ''[[Anime/MobileSuitGundamSeed Gundam SEED]]''. Due to his [[NukeEm method o]][[KillSat f choice]], it just might reach Class 4 or Class 5.

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* This is the BigBad's goal in ''[[Anime/MobileSuitGundamSeed Gundam SEED]]''.''Anime/MobileSuitGundamSeed''. Due to his [[NukeEm method o]][[KillSat f choice]], it just might reach Class 4 or Class 5.



* It's not explained what happened in ''Anime/GirlsLastTour'', but whatever it was wiped out most of the life on the artificial world where the protagonists live. At this point, humanity's population appears to have dropped well below sustainable levels.
* ''Manga/{{Devilman}}'' sees the world slowly fall apart as a result of [[spoiler:the machinations of Ryo Asuka, who is actually the fallen angel Satan. The war between demons and humanity eventually leaves humanity extinct, and the world is destroyed in the final battle between Satan and Devilman. The anime series ''Devilman Crybaby'' shows another version of this apocalypse: after the existence of demons becomes public knowledge, humanity becomes paranoid and largely wipes itself out in the world war that follows.]]

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* It's not explained what happened in ''Anime/GirlsLastTour'', ''Manga/GirlsLastTour'', but whatever it was wiped out most of the life on the artificial world where the protagonists live. At this point, humanity's population appears to have dropped well below sustainable levels.
* ''Manga/{{Devilman}}'' sees the world slowly fall apart as a result of [[spoiler:the machinations of Ryo Asuka, who is actually the fallen angel Satan. The war between demons and humanity eventually leaves humanity extinct, and the world is destroyed in the final battle between Satan and Devilman. The anime series ''Devilman Crybaby'' ''Anime/DevilmanCrybaby'' shows another version of this apocalypse: after the existence of demons becomes public knowledge, humanity becomes paranoid and largely wipes itself out in the world war that follows.]]



* In current ComicBook/MartianManhunter continuity, this is what Malefic did to Mars, using a virus to kill all Green Martians.
* ComicBook/PostCrisis. Everyone in the alternate Earth of the Pocket Universe were killed by that universe's General Zod, Faora ([[AdaptationNameChange renamed Zaora]]), and Quex-Ul. They even destroyed the planet's biosphere so no one would survive without a spacesuit. Matrix (the Post-Crisis Supergirl) is the only survivor. Also, Earth and Krypton were the only inhabited planets, thanks to the manipulation of the Time-Trapper. Likely, any other Kryptonian criminals in the Phantom Zone remain trapped there. Following ''ComicBook/ZeroHour'', the lifeless Pocket Universe is wiped from continuity, making this a Class X-4.

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* In current Post-Crisis ComicBook/MartianManhunter continuity, this is what Malefic did to Mars, using a virus to kill all Green Martians.
* ComicBook/PostCrisis. Everyone In Franchise/{{Superman}} story arc ''ComicBook/TheSupergirlSaga'', everyone in the alternate Earth of the Pocket Universe were killed by that universe's General Zod, Faora ([[AdaptationNameChange renamed Zaora]]), Zaora]]) and Quex-Ul. They even destroyed the planet's biosphere so no one would survive without a spacesuit. Matrix (the Post-Crisis Supergirl) [[ComicBook/{{Supergirl}} Matrix]] is the only survivor. Also, Earth and Krypton were the only inhabited planets, thanks to the manipulation of the Time-Trapper. Likely, any other Kryptonian criminals in the Phantom Zone remain trapped there. Following ''ComicBook/ZeroHour'', the lifeless Pocket Universe is wiped from continuity, making this a Class X-4.



* In ''[[FanFic/IcedFairysANewWorld A New World]]'', the remnant of Lunarian society is so scared of human expansion on the False Moon, they see fit to seize control of Earth's nuclear arsenals and trigger a colossal war. [[spoiler:[[AllForNothing It turns out to be worse than useless]], as it was ''[[BatmanGambit exactly]]'' what [[ManipulativeBastard Yukari]] wanted them to do. Earth ''does'' suffer greatly... but the Lunarians are left extinct and their worst nightmare, the complete fusion of the worlds of magic and science, is brought into reality by humans and the magic races.]]

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* In ''[[FanFic/IcedFairysANewWorld A New World]]'', ''FanFic/IcedFairysANewWorld'', the remnant of Lunarian society is so scared of human expansion on the False Moon, they see fit to seize control of Earth's nuclear arsenals and trigger a colossal war. [[spoiler:[[AllForNothing It turns out to be worse than useless]], as it was ''[[BatmanGambit exactly]]'' what [[ManipulativeBastard Yukari]] wanted them to do. Earth ''does'' suffer greatly... but the Lunarians are left extinct and their worst nightmare, the complete fusion of the worlds of magic and science, is brought into reality by humans and the magic races.]]


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* In ''Fanfic/TheInstituteSaga'', ComicBook/{{Magneto}} almost initiates an ''accidental'' version while trying to create a Mass Super-Empowering Event.

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* ''VideoGame/FateGrandOrder'': The Prologue features an event known as "The Incineration of Humanity". This is not an exaggeration, if anything it's an ''understatement'': the entire human race is wiped from existence in an instant, past, present, and future, such that it never existed in the first place. The player and the supporting cast are only still alive because their organization's unique status in the timestream created a paradox that is sustaining their existence... but it will only last two years before the paradox resolves itself and they get wiped out too. The first part of the game is spent investigating several other paradoxes left behind through history to figure out ''what the hell just happened''.


* Geologist Dougal Dixon wrote (and illustrated) the literally science fictional ''After Man'', a really quite detailed description of the various ecosystems of Earth 50 million years from now, with the base assumption that humans go extinct some time "soon" in geological terms (i.e. within the next 100,000 years or so).


* Another technically-non-human example in ''WesternAnimation/StevenUniverse'': about 5,000 years ago, Gems were the dominant civilization on Earth but in open revolt against their extraterrestrial masters. Eventually [[BigBad the Diamonds]] caused something, alternately described as a light or a song, that corrupted all unprotected Gems on Earth. While the corrupt Gems are still around, they demonstrate only animal-level intelligence, unable to form much of a civilization. The few Gems on Earth that are both uncorrupted and free have been hunting them down and capturing them ever since.

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* Another technically-non-human example in ''WesternAnimation/StevenUniverse'': about 5,000 years ago, Gems were the dominant civilization on Earth but in open revolt against their extraterrestrial masters. Eventually [[BigBad the Diamonds]] caused something, alternately described as a light or a song, that corrupted all unprotected Gems on Earth. [[spoiler:It was ''meant'' to just straight-up kill them.]] While the corrupt Gems are still around, they demonstrate only animal-level intelligence, unable to form much of a civilization. The few Gems on Earth that are both uncorrupted and free have been hunting them down and capturing them ever since.

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** Although this is becoming less likely now that global politics are shifting. While all current nuclear power reside primarily in the northern hemisphere, many of them have allies in the southern hemisphere that may be targeted during a nuclear war to deny them things like naval and air bases. That said, the scale of nuclear war in the southern hemisphere would still be smaller than that of the north, making it slightly more possible to live there, but global biosphere collapse could still render humanity extinct through the eradication of food sources.


* In ''VideoGame/{{Splatoon 2}}'', Commander Tartar has developed a beam weapon capable of reverting every Inkling and Octoling (and presumably all other sentient life on the planet, which would make it a Class 4) back into primordial ooze, which he also uses to power that weapon. [[spoiler:Tartar is a human-created AI programmed to pass mankind's knowledge to the next dominant sentient species on Earth. The problem is that Tartar is a LoonyFan of humanity, of sorts, and wants to wipe out the Inklings and Octolings as [[AIIsACrapshoot he doesn't consider them worthy successors]].]]

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* In ''VideoGame/{{Splatoon 2}}'', Commander Tartar has developed a beam weapon capable of reverting every Inkling and Octoling (and presumably all other sentient life on the planet, which would make it a Class 4) back into primordial ooze, which he also uses to power that weapon. [[spoiler:Tartar is a human-created AI programmed to pass mankind's knowledge to the next dominant sentient species on Earth. The problem is that Tartar is a LoonyFan of humanity, of sorts, and wants to wipe out the Inklings and Octolings as [[AIIsACrapshoot he doesn't consider them worthy successors]].]]


* Webcomic/BobAndGeorge [[http://www.bobandgeorge.com/archives/041128c We're willing to kill everyone on the planet to stop you!]] This being Webcomic/BobAndGeorge, people at the site of the asteroid strike survive.

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* Webcomic/BobAndGeorge ''Webcomic/BobAndGeorge'': [[http://www.bobandgeorge.com/archives/041128c We're willing to kill everyone on the planet to stop you!]] This being Webcomic/BobAndGeorge, people at the site of the asteroid strike survive.


* Literature/TheLongestJokeInTheWorld: The lever. If pulled, it kills all humans. It's a safety measure, in case the species goes bad.

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* Literature/TheLongestJokeInTheWorld: ''Literature/TheLongestJokeInTheWorld'': The lever. If pulled, it kills all humans. It's a safety measure, in case the species goes bad.


* ''Spiral'', the second book in Koji Suzuki's ''{{Ring}}'' trilogy ends like this. [[spoiler: Sadako's curse will inevitably spread across the world, destroying the human species. That is, of course, until the next book turned everything on its head by revealing that it all took place inside of a computer]]

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* ''Spiral'', the second book in Koji Suzuki's ''{{Ring}}'' ''Literature/TheRing'' trilogy ends like this. [[spoiler: Sadako's curse will inevitably spread across the world, destroying the human species. That is, of course, until the next book turned everything on its head by revealing that it all took place inside of a computer]]


* By the time of ResidentEvilTheFinalChapter, the ZombieApocalypse has caused the human population to dwindle from seven billion to less than five thousand. [[spoiler: The Umbrella Corporation considers this disappointingly incomplete.]]

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* By the time of ResidentEvilTheFinalChapter, ''Film/ResidentEvilTheFinalChapter'', the ZombieApocalypse has caused the human population to dwindle from seven billion to less than five thousand. [[spoiler: The Umbrella Corporation considers this disappointingly incomplete.]]


** In ''Anime/DragonBallSuper'', [[spoiler:Goku Black hunts down and kills off 99 percent of humanity in Future Trunks's timeline with Trunks and Mai being of the only known survivors.]]

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** In ''Anime/DragonBallSuper'', [[spoiler:Goku Black hunts down and kills off 99 percent of humanity in Future Trunks's timeline with Trunks and Mai being of the only known survivors.timeline.]]

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* ''VideoGame/BeyondTwoSouls'': The main character receives premonitions of this happening, and it does if you fail to stop the [[spoiler: second Condenser]] after [[spoiler: Nathan Dawkins goes kuku and shuts its forcefield down.]]

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