These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Family-Unfriendly Aesop: The episode "Ice Man" basically tells us that ugly people can only find love with other ugly people.
Jerkass Woobie: Hercules is a mean Chihuahua with a spiked collar who is one of the bully dogs in the neighborhood. Turns out he's just lonely and wants a friend, which is why he stole Pookie in one episode.
Take That, Scrappy!: In "Parrot Blues", Nermal breaks down in tears because Paxton called out on him for his conceit and told him that he was a sickening sight to those around him.
Tear Jerker: "Desperately Seeking Pookie". The scene where Hercules breaks down in tears when he has to part with Garfield's teddy bear. Even though he stole it, the scene is enough to qualify poor Hercules as a Jerkass Woobie and makes the viewer want to hug him. Luckily Garfield decides to Throw the Dog a Bone, and donates his numerous failed replacements for Pookie.
"Long Lost Lyman: Part Four", where Odie had to part ways with Jon and Garfield after reuniting with Lyman. The part where a downhearted Garfield reminisces the times he had with Odie really sells it. Thankfully, Lyman decides that Odie should live with Jon.
Also, it could be argued that the humor is much more tame, less funny, too many 4th wall jokes and forced aesops comapred to Garfield and Friends.
Uncanny Valley: Believe it or not, Garfield moving his lips when he talks is this for some fans, especially those who grew up watching Garfield and Friends. It's so unbelievably jarring.
Some viewers have noted how wrong most of the characters look in CG. It's especially notable when characters such as Garfield or Odie switch from walking between two to four legs meaning different models with different body lengths/shapes must be used thus making the transition between them so obvious.
The Rowdy Reviewer: "...no one can replace the late, great Lorezno Music. He was Garfield. But legendary voice talent Frank Welker? I must say that....I'm less than impressed. With him, it's all lethargy and no sarcasm, while Music always had the best mix of both."