These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Chapter 46 adds Steabe Jocks to the list: he is a Corrupt Corporate Executive whose company is developing a medicine to make fat people become compulsive overeaters (or more so than they were, depending) so they can profit as their customers consume more of their products. He is also the first character in the series to outsmart Fran, and apparently didn't care that the girl who Fran was trying to help with his medicine ended up killing a classmate and then died consequently.
Evil Is Sexy: The only one of the Madaraki sisters to be indisputably evil, Gavrill also has the most fanservice-laden chapters and has the most voluptuous figure.
Family-Unfriendly Aesop: It's not known whether the author intended to put them in the story, but there are still subtle messages. The most obvious one is in chapter 23 Justice, where a man gets modified by Fran into a super hero named Sentinel. He starts killing criminals, only to be hunted down later by the relatives and loved ones of those he killed.
Well, it's a deconstruction of the typical Toku program. The hero, by using Fran to become stronger and stronger, eventually morphs into a toku-esque monster, who is then attacked by new Toku-esque heroes, who are then augmented themselves... and so on.
In-universe example: Gavrill goes to teach at a school, and promptly starts giving students advice involving: how to rape a girl, how to buy your way into universities, and how to become a Gold Digger.
I Am Not Shazam: The title character is named Fran Madaraki. She has never actually been referred to as Franken Fran.
Nightmare Fuel: This manga is not for the faint of heart. Or for those with a particularly strong religious conviction. (Not that it portrays religions badly in most cases, just the content of the work.) Or those who don't want to see human entrails rendered in loving detail. Now, if you excuse me, I've just finished the second chapter and feel a particularly strong desire to vomit and repent, followed by a helpful round of tossing in my bed. Consider yourself warned.
Then there's Gavrill who first appears in Chapter 40. Never mind the fact that she's a cruel and sadistic killer. Never mind the fact she was first introduced in the manga as she was eating someone's remains. Never mind the fact that she flat out tears Veronica apart. It's what she can become that puts her into this territory. And she always appears to be very hungry. Very, very, hungry.
In chapter 30 the people who get off on nearly killing themselves manage to squick out Fran.
Tear Jerker: Chapter 38. One of the few times the final result of Fran's work is not played for Nightmare Fuel.
Also in the ending of chapter 43, where a rich girl's uncle who formerly came to Fran for a brain transplant ended up sharing a body with her due to an "incomplete" opperation. When a bomb goes off in her house and several people who were after the inheritence she recieved were killed, the uncle has his own brain put in the girl's old body while he made Fran put the girl's brain into a clone of her. The other people who got killed ended up sharing the old body along with him, as was the uncle's wishes just so that the girl could live freely.
Chapter 25 when Veronica is almost sold to a pedophile group by the only friend she made on school. The saddest part? She knew it all the time, but stuck around as the girl was the only one at school who treated her nicely. And at the end, Veronica said the only phrase that can be used to comic relief and heartwarming at the same time: I'm not crying...I SAID I'M NOT CRYING!
Chapter 48. The somewhat Sympathetic Murderer Nogizaka finally finds happiness... comatose and dreaming of a fantasy world where, finally, there are people who love her. Come to think of it, this fact is what makes said character sympathetic.
Okita, the cat with a guy's head. Said head (if you ignore the cat body) is actually quite handsome, as demonstrated when Okita used a puppet human body. Many of Fran's other creations also count, such as her dog-headed butler.
And Veronica, if you consider that she passed through quite a hell after she separated from Professor Madaraki and before she found Fran: Having a dog as her only companion (which very likely have died), being scolded as a freak and constantly targeted by the mysterious organization that wants the professor's secret projects. Not to mention the bad things that occasionally happen to her, like the bullying she had to endure in chapter 25 - though in that case she came off as an Iron Woobie. Also, Fran apparently likes to take her apart and do...things to her.
We all know that Gavrill is a strong, bloodthirsty killer, who has no mercy and kills on a whim. Her name is of Jewish origin, and it means "God is my might," or, "Strength of God." Gavrilo Princip was the man who assassinated Archduke Franz Ferdinand and his wife, marking one of the events that started World War I. It's possible Gavrill was based off of Princip (Especially considering one of the men she killed was called Franzel).