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Created by Naomitsu Madaraki, the world's greatest biologist, she was given superhuman surgical skills and left to handle the Madaraki estate and its engineered inhabitants. She is frequently sought by those eager to make use of Naomitsu's or her skills. Unfortunately, while given incredible skills by the Professor, she has also been left with an extreme aversion to killing, and possesses an almost child-like naivete in regards to the often horrific consequences of her actions.
Artificial Human: Like all of Madaraki's creations, Fran is a human made out of multiple body parts which are simply pointed out by the stitches.
Half the Man He Used to Be: She accidentally gets split straight down the middle by a laser in Chapter 60: "Left And Right". She simply replaces the necessary things for each half, ending with two Frans (which later become one again). That's right, she managed to survive and cure BISECTION.
Helpless Good Side: While recovering from getting cut in half bilaterally, Fran-M is nice and actually cares about her patients' quality of life, but is rather a pushover.
Obliviously Evil: Doesn't seem to be aware of the horror she constantly causes with her work.
Nor does she seem to care that much when she does realize it, though this is mostly because she thinks that no matter how shitty a life can get, it's still better than death. And boy is she wrong.
Off with His Head!: Almost ended up with this—a hired killer slit her throat deeply enough for her head to barely hang on to her neck. Predictably, she not only survives, she performs emergency surgery on herself and lives on like normal.
Red Oni, Blue Oni: The Blue to both Veronica and Gavril, though not so much to Veronica. And then she manages to establish this dynamic with herself in "Left and Right"when she ends up as two Frans, with one being aggressive, greedy and rude, but logical, while the other is much more passive, gentle and kind, but so altruistic that other people can easily push her into doing what they want.
She's quite talented at finding loopholes around this when she has sufficient cause to, whether it's merely inflicting a Fate Worse Than Death, or empowering someone else to kill the people she wants dead under the excuse that it was up to them to use their powers and she had no way of being certain how they would.
If someone is about to die anyway, she does let Adorea harvest the person's organs. This has to happen before death or the organs could suffer damage.
Up to Eleven: First she gets a close shave due to Off with His Head!...and then she goes and makes Half the Man He Used to Be seem trivial to deal with. In all fairness, she's not a normal person by any stretch, and in the later case she admitted she was fortunate enough to have been split straight down the middle so that her brain hemispheres were simply divided and not damaged.
Another, later, creation of the Professor, she was created to serve as his bodyguard, and is thus very much willing to resort to murder, though quick about it. She initially shows up as an antagonist, attacking the Madaraki estate after having been separated from the Professor. At first quite hostile to Fran, out of envy of her comfortable life and dislike for Thou Shalt Not Kill attitude, though after some experiments by Fran she becomes her willing bodyguard and foil.
X Marks the Hero: The scars on her face form an X shape. It's sometimes hard to see in full because of her fedora, but it's there.
A man with the body of a cat (or possibly a cat with the head of a man), Okita is another member of the Madaraki Estate, and much more down-to-earth than Fran. He usually serves as a voice of reason, that is, when Fran listens to him.
A young girl saved from death by Naomitsu Madaraki, though by the time he did it was too late to fully restore her. She now serves as a walking organ bank, consuming and storing organs for whenever they might be needed.
AB Negative: To be precise, because she stores so many organs for Fran to use, she's got a lot of different blood types in her body, the dominant type constantly changing. This becomes a major plot-point in chapter 57.
I'm a Humanitarian : That's one of the ways she can store spare organs and different blood types for Fran. It makes her look a bit chunky, though.
It's also not necessarily lethal, as she can spit them out before they die (Fran does still need to heal them, though).
Pop Goes the Human: In chapter 57, her body basically goes like this and her zippers all break open because she's eaten so many students. It's as nasty as it sounds, but surprisingly and fortunately, she survives.
The Ingenue: Well she's definitely gentlier and kinder than the sisters but as for innocence....
A recurring minor character; A female police officer who crosses paths with Fran and/or the results of Fran's experiments several times.
Butt Monkey: In just about every chapter with her, something happens at the expense of her sanity.
Sanity Slippage: She snaps during the latest chapter featuring her after finding out the latest batch of clones of her Fran made are being used for the fantasy of some lightly crazy dude. And as if that wasn't bad enough, she is then mistaken for one and turned into a monster.
At one point, she was attacked by the monster of the week, despite having nothing else to do with (or even appearing in) the chapter. She immediately chalks it up to Fran's antics and never mentions it again.
Tomato in the Mirror: Whenever Fran needed clones for anything, she usually comes to Kuhou for the necessary "genetics". Due to her method of cloning (which was Cell Mitosis done on a full human being), the implication is that Kuhou seen in subsequent chapters isn't technically the same girl that Madaraki keeps kidnapping off the streets. Given Fran's loose moral ethic, she sees no problem in this.
Unexplained Recovery : A few chapters after being transformed into a Cute Monster Girl, she is seen again as a human, with no explanation of how she was turned back or even the slightest mention of her time as a monster girl.
The elder sister of Fran and Veronica, Gavrill is one of the earliest creations of Naomitsu Madaraki. She is violent and quite foul mouthed. Also, unlike her younger sisters she has absolutely no value for life.
Awesome by Analysis: With her sense of smell, she can basically deduce everything about a person. And if her "lessons" during her time as high school teacher is anything to go by, she's one hell of a Diabolical Mastermind. Sherlock Holmes would be screwed trying to outsmart her...
Ax-Crazy: Just to give you an idea, her preferred form of combat is transforming herself into a huge wolf-like beast and ripping her opponents to shreds. All the while with an insane grin on her face. It's slightly subverted as well, though, for as insane and bloodthirsty as she is, she's very sly and intelligent.
Badass Teacher: In two volumes, Amatsuka asks her to become teacher at high schools, one of which was filled with spoiled brats from rich families, three of which tried to beat and probably rape her. She was forbidden to kill anyone, but she managed to make all students like and come to her for councils, simply because she bluntly stated how they should solve their problems. Sounds good so far, right? Said problem-solving started when she gave the aforementioned boys some pointers in rape, and continues with solutions such as the girl who asked for study help so she could get a good job:
Gavrill:For you, I recommend spreading your legs for some gullible rich fucker while you've still got your looks. Once you're all good and knocked up, force him into a marriage, then mess with his medications and you'll inherit all of his money.
Although she does occasionally give good advice, like when she told a fat girl seeking to lose weight that TV diets are cash-grab scams and told the girl seeking to get taller that while she could try to eat and exercise more, it would be more effective to start thinking of ways to take advantage of her short height.
Berserk Button : If you value your life even a little, then for the love of Chrysler, do NOT fuck with Dr. Amatsuka.
Body Horror: This is what happens when a character is labeled a "transformer" without being a robot. Apparently she is capable of rearranging every part of her body (muscles, organ, even bone) to her desire as long as she has the willpower to do so, allowing her to produce whatever she needs to maul someone at a moment's notice with her flesh.
Determinator: Fran notes that, until she saw Gavrill, she thought that a "transformer" was impossible because you need to have an extremely strong willpower to keep your body from imploding into the various tiny muscular organs that now made up the body. Gavrill not only can keep her form without any sort of effort, but can also change into her combat form fluidly, indicating she has exceptionally strong willpower to maintain her body.
Diabolical Mastermind: For an ultra-violent cannibal monster, she has got great wits and some persuasion skills. She controls an gang (read "army") of thugs and she can be so insightful and convincing as a school counselor, she could very well become a professional Crime Boss like Kingpin if she ever wanted to.
I'm a Humanitarian : The very first thing we see her doing is eating the severed arm of a guy she had killed moments earlier.
Jerkass: The series has a lot of them, but she's one of the worst. As if casually slaughtering people for no apparent reason isn't enough, she loves to see people suffer, mentally or physically. An example is in chapter 59 : Veronica pretty much begged her to tell her who were the guys who had murdered her best friend. Gavrill told her that a lot of people were involved, more or less directly, in her death, but forbid her from laying a hand on any one of them or else she would kill Fran and everyone else that lives in the Madaraki mansion. Why did she do that ? Because she wanted her sister to wallow in despair. Holy shit.
Then again, that particular example may be a particularly twisted case of Pet the Dog, as Gavrill had stated shortly earlier that her sense of smell was so good that she could smell any illnesses people had... meaning that she knew that the murderers were going to die soon anyway, and in a far nastier way than the brutal but efficient Veronica would have killed them. So in her own warped way, she may have been doing Veronica a kindness...
The Juggernaut: A low-yield nuke (despite destroying the island she was currently standing on) did little more than mildly annoy Gavrill because she had to swim all the way back to land.
When Dr. Amatsuka was attacked, Gavrill went on a Roaring Rampage of Revenge and killed one of the men responsible for it. The guy's bodyguards obviously tried to defend him by basically unloading their machine guns at her. She didn't even flinch. Hell, she even laughed all the way.
As mentioned above, a low-yield nuke was only a minor annoyance to her.
Morality Chain: Doctor Amatsuka is this for Gavrill during the chapter where she serves as a relief teacher. It's only his requests that stop her from literally eating her students despite her general contempt for them.
Cursed with Awesome: She points out that having supersenses in a school full of teenagers is absolute hell, since she can smell even the faintest trace of semen and menstral fluid, but given that the boys arn't exactly discreet about it and the girls can't control it, they're basically grinding their crotches against the inside of her nose.
Another recurring minor character. He's been a friend of the Madarakis (Even Gavrill) since the days of the old Japanese Empire. His various achievements have earned him the title of Viscount of England. He sometimes aids Fran in whatever she's doing at the time, and performs check-ups on Gavrill every month.
Alternate Character Interpretation: In-universe, people tend to have wildly different opinions on him. The general public (at least, those who know about him) tend to regard him with fear and awe, Fran and Veronica idolize him, and Gavrill seems to despise him.
The Unreveal: We see a young Naomitsu when we're introduced to his colleague Dr. Amatsuka, who has a flashback to a moment the two shared. Unfortunately, Naomitsu's face is partially obscured by the shadow cast by the brim of his naval hat. On top of that, when we see a young Dr. Amatsuka, he looks nothing like the wrinkled old man in the present day, so there's no way to even guess at what Naomitsu would look like now.