Martin Billany was born in Knutsford, which is where Nylocke's player resides.
Asterob's, hat glasses, and his tendency to use mannerisms portraying him as an apologetic brit have been said by Niosi to be a reference to the actor who plays him.
Ravenfreak's voice actor is... well, a voice actor (Lucien Dodge to be precise).
In episode 4, Rockoon, in exasperation after having been constantly misidentified as a rodent, exclaims "Do I look like a lab rat?" His voice actor, Deven Mack Jr., played the character of Lab Rat in Grossology.
In addition, while taunting Nylocke's dramatic tone, Mack performs a voice similar to the one he uses to perform DotDotDot, complete with kinetic typography.
Apparently Michele Knotz is just as goofy and lighthearted as Kindarspirit when she's out of character.
JonTron was chosen for Sniperwheel because he had a very entertaining fake New York accent that he put on in his youtube videos.
Actor-Shared Background: The characters in TTA and TOME are all based on users from, the now defunct, TV Tome forums to an extent.
Celebrity Voice Actor: Unlike most of the rest of the cast, Jafari is not a voice actor by trade, though he was chosen because of the fake Noo Yawk accent he sometimes puts on in JonTron videos.
Contest Winner Cameo: Auctioned on Ebay. These are sold to fans to promote the show in some of the episodes, The winners send Niosi their own character designs which he TOME-ifies into something that fits the show. They then get inserted into certain scenes to appear near some of the recurring characters. A couple cameos even have brief speaking lines.
The Danza: Like his creator, the character Kirbopher's username is Kirbopher, and his real name is (probably) Christopher.
Micah Solusod as Archy. His fellow voice actress and girlfriend Apphia Yu voices Whyti.
Michele Knotz provides TOME's "System Voice" narration in episode 1 and the Traveler's Guide and voices Kindarspirit in episode 10. She's most known for various voices in Pokémon from seasons 9 onward, including major characters like May and Jessie.
I Knew It: It turns out that Kirbopher and Zetto are controlled by the same player. This was a popular fan theory (just check out the WMG page for proof) which was finally confirmed in the season finale.
It Was His Sled: Kirb being Zetto quickly became this after it was confirmed. You can't even go through a Youtube comment on the reuploads without finding it somewhere.
Missing Episode: The Season Finale, "The Warring Demons", and the final short, "Plan Z", are not planned to be hosted on Newgrounds, the show's original home.
Non-Singing Voice: Anna Kingsley, Flamegirl's voice actress, wasn't confident that her singing was strong enough to do the end credits song "Starlight Speedway" justice, and referred Niosi to her friend Leila Judeh who could match her Flamegirl voice for the song. Kingsley herself described Judeh as sounding "just like me but with a better singing voice".
Real-Life Relative: Chris Niosi and Alison Fanelli (who voices Splat) are brother and sister.
Averted, surprisingly enough. Even though the cast is filled with a roster of incredibly talented and versatile voice actors, each of them plays only one character. Or rather, one player - characters who are controlled by the same player share their voice actor. This was one of the earliest hints that Zetto and Kirbopher were one and the same - both were voiced by Chris Niosi. Zetto and Tigerlilly were also credited as having been played by other actors than the ones who played Kirbopher and Kizuna respectively, before The Reveal.
This promotional video. for Kirbopher's panel, premiering a new TOME episode at Kamicon, starts with Yami Yugi, introducing Kirbopher, and failing at pronouncing Kirbopher's name correctly. Then Nylocke drops in to try to help! Hilarity ensues.
Throw It In: Nylocke interrupting his monologue about the Gemini Tournament in "Awaken the Beast" to confirm with GC that it involves pairs was actually Billany checking his line with Niosi as he was running through it, staying in character - Niosi enjoyed his reading so much that he put it into the finished episode.
What Could Have Been: Though Nylocke was always intended to be English in the remake (the original was American, though an Occidental Otaku), Niosi had originally considered Casey Mongillo (an American, who was instead chosen for Gamecrazed) and Blake Swift (who presumably would have spoken with his natural English accent instead of the Fake American he uses as Alpha) for the part. Martin Billany was considered for a part, but it was Thorment, which eventually went to Harry Partridge.
Jessi Nowack, who played Hyprelynx, was the first runner-up for the role of Flamegirl, and apparently only narrowly lost the part to Anna Kingsley.
Write Who You Know: Most of the characters in TTA and TOME are originally based on members of the TVTome forums. Kirbopher15 and Zetto are both based on (different aspects of) Niosi himself, Alpha is based on his best friend Mike Luckas (Ultimate Creature II), and Ruri and Flamegirl were based on their respective girlfriends at the time.
None of the characters appear in every episode of Season 1, but Nylocke comes closest, appearing in nine out of ten episodes (missing episode 07), and four out of seven shorts (though two of those - 02 and 07 - are in stock footage). Of the five main characters, Alpha and Gamecrazed are tied for the fewest appearances, in just eight episodes and the two stock-footage shorts (although Kirbopher, though he appears in nine episodes, is only seen at the very end of episode 09, and has no dialogue).
Short 05, "Rockoon's Modern Strife", is the only episode or short with original footage that does not feature any of the Five-Man Band. Alpha's one "new" line in Rockoon's "flashback" is provided by Deven Mack.
Alpha has never appeared in an episode without Flamegirl, and Gamecrazed has never appeared in an episode without Nylocke or Kirbopher. Only two members of the Five-Man Band have appeared solo: Nylocke (in shorts 03 and 06) and Flamegirl (in short 04).
Of the five main characters, four of them sing at some point during the run of the show:
Alpha performs "Battle On" (original version and rock remix), and "Starlight Speedway'';
Kirbopher performs "Battle On" (original version and jazz remix, though he may be performing the latter as Zetto);
and Nylocke, of course, performs "Nylocke's Theme Song". He's the only character who sings "in-universe", as opposed to over the end credits.
The longest episode is "Fraggedquest", at 29:29; the briefest is "Infectuation", at 16:31. The longest short is "The Legend of Nylocke", at 09:05; the briefest is "Hackers", at 02:44. (All lengths are taken from the Blip versions.)
The standard version of "Battle On!" has not been heard on the show since episode 04; however, eight of ten episodes end with some variation of the song. Only episodes 05 (which uses "The Devastating Aftermath", in its only appearance) and 07 (which uses a cover of "Starlight Speedway") do not.
Of all the prominent characters (which is to say, the ones who receive character bios on Niosi's Deviantart and Tumblr - merging characters who are known to share the same player, and excluding Demon Alpha and Demon Zetto):
19 are male, and 10 are female. Assuming that this is a representative sample, it means that about 1/3 of TOME's users are female.
National origins break down thusly:
14 are from the United States (again, assuming a representative sample, this means that about 1/2 of TOME's users are American)
5 are from the United Kingdom
2 are from Canada
1 is from Japan
1 is from China
1 is from Vietnam
and 5 have an unknown origin
And character classes break down like this ( this time counting all the characters shared by individual players, because their classes may differ):
7 are Fighters
4 are Swordsmen
5 are Spellcasters
3 are Morphological
9 are Animalistic, making it the most common class;
2 are Mechanical, making it the rarest class
and 2 have an unknown class
Most Mechanical-class characters have a characteristic reverb to their voice (Sniperwheel, Armoora, the Spear Carrier voiced by Liz Losey), but Elescope, strangely, does not.
Missing Episode: Newgrounds viewers would never see The Movie (leading to confusion when the season 3 finale references it) or the Anime Openings.
Promoted Fanboy: There was at one point a call for fans of the series to submit avatars for use as "extras". Most of the Netkings also seem to be Fanboys or Fangirls.
What Could Have Been: There was supposed to be a season 4 of TTA, but it has been unceremoniously canceled because Niosi had a lot less time to work on the series. A good portion of the fanbase was definitely not pleased with this outcome. And it's a shame, considering the material prepared would've been grand in scale and epic as hell.