Popeye's most well known actor, Jack Mercer, is also known for his role as Felix the Cat (and many other voices) in the 1960's TV cartoon.
Olive Oyl has the same voice as Betty Boop, Mae Questel.
For a brief period of the Miami Florida produced Popeyes, Bluto was voiced by Pinto Colvig, more known as the original voice for Goofy.
The Other Darrin: Popeye has gone through several voice actors through his time. His first, William Costello (AKA Red Pepper Sam) was fired due to his ego getting to his head, and he became impossible to work with. And for "Be Kind to Aminals", the studio inexplicably hired Popeye's radio voice actor, Floyd Buckley, to voice him. Jack Mercer would assume the role of Popeye for decades starting with "King of the Mardi Gras", but on one occasions where he was not available, another voice actor briefly substituted for him, and even Mae Questel would substitute for Mercer now and then!
Olive Oyl and Bluto also had rotating voice actors; Bluto is especially notable for having two major actors throughout the theatrical run; Gus Wickie for the bulk of the B&W cartoons, and Jackson Beck for the Famous Studios shorts, both bringing very distinct interpretations of the character.
Nintendo's Super Mario franchise, probably the most significant in videogame history, was essentially made with original characters because the company lost the rights to make Popeye arcade games and had to retool what they already had into Donkey Kong... Ironically, they did produce a Popeye video game a year later. It played nothing like Donkey Kong, however.
Some sources claim that the Popeye franchise only exists because a scientist Misplaced a Decimal Point when reporting the amount of iron in spinach. This claim is false. There was no erroneous decimal point. Segar created Popeye and later added spinach.
Artistic License - Biology: In Females is Fickle, Olive's goldfish jumps over the edge of Popeye's ship, and she screams "Oh Popeye save my goldfish! He'll DROWN!!"