Franchise Killer: Streetwise sold and was received poorly, spelling an end to Final Fight as a standalone franchise. Some of the more popular characters (Guy, Cody, Haggar, Maki, Poison, Rolento, etc.) began making appearances in the Street Fighter series as early as Street Fighter Alpha.
Port Overdosed: In close competition with Double Dragon for the title of "most-ported beat 'em up ever". Almost every contemporary home computer and console had a version, and Capcom has frequently re-released it since then, too.
Shrug of God: Adding even more complexity to the gender confusion, Yoshinori Ono, when asked about Poison, said Capcom doesn't have an official policy to what Poison's gender is, stating that in North America she is a post-op transsexual but in Japan she is a pre-op transsexual/futanari/newhalf who "tucks her business away to look female".
For years, it has been speculated that there was a Final Fight animated series with The Ocean Group doing the voice work much like they did for Mega Man, Street Fighter and Darkstalkers. Sites like IMDB even use to have a full voice cast for the show. It's uncertain whether if the show never existed, a Pilot Episode was produced but that went into obscurity like Battletoads, or if the series was planned but never materialized. Granted the Street Fighter animated series did end up having a Final Fight episode but still.
Vanessa was supposed to be a playable character in the story mode of Streetwise.
The first game was orginally going to a sequel of the original Street Fighter titled Street Fighter '89. The reaction from the audience noted how different it was from the previous game, and was retitled.
Poison was supposed to be included in Streetwise.
Sodom was slated for an appearance in Streetwise. Concept art shows him sporting a more modernized version of his attire (namely ragged jeans).
The amount of points the player gets when picking up Edi.E's gum at full health is 42910. This number forms a date: 42, September 10th. Said date is developer Akira Nishitani's birthday, but the 42 doesn't refer to 1942, instead meaning "Showa 42" or "1967".