Franchise Killer: Streetwise sold and reviewed poorly, spelling an end to Final Fight as a stand-alone franchise. Some of the more popular characters (Guy, Cody, Haggar, Maki, Poison, Rolento, etc.) began making appearances in the Street Fighter series as early as Street Fighter Alpha.
Port Overdosed: In close competition with Double Dragon for the title of "most-ported beat 'em up ever". Almost every contemporary home computer and console had a version, and Capcom has frequently re-released it since then, too.
Vanessa was supposed to be a playable character in the story mode of Streetwise.
The first game was orginally going to a sequel of the original Street Fighter titled Street Fighter '89. The reaction from the audience noted how different it was from the previous game, and was renamed.
Poison was supposed to be included in Streetwise.
Sodom was slated for an appearance in Streetwise. Concept art shows him sporting a more modernized version of his attire (namely ragged jeans).