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This is a "Wild Mass Guess" entry, where we pull out all the sanity stops on theorizing. The regular entry on this topic is elsewhere. Please see this programme note.
Final Fight
Poison is actually a case of complete androgen insensitivity syndrome
Complete androgen insensitivity syndrome is an actual condition in which a person will have male chromosomes, but develop physically female. Poison is always depicted with a female body, including very large breasts, and in recent games is voice acted by a woman. Despite Capcom's inability or unwillingness to outright say what Poison is, this would make more sense than Poison being a cross-dressing man or undergoing Easy Sex Change surgery- and being realistic, a low-level street punk with no money and a probable criminal history probably isn't paying for any extensive surgery. CAIS would likely better explain the gender confusion without breaking current canon or going against her character artwork.
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