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Tear Jerker: House
The season finale for the fourth season is full of them.
When House talks to Amber in the Limbo-bus. "I don't want him (Wilson) to hate me." A classic example of petting the dog. "Because...because it doesn't hurt here. I don't want to be in pain. I don't want to be miserable. And I don't want him to hate me."
It didn't help that the music selection used as the bed for that scene was Iron & Wine's "Passing Afternoon".
Taub clinging to his wife.
Wilson finally going back home to try and sleep and finding Amber's last note.
The scene where Amber dies in Wilson's arms, after having him to pull the plug on the machine keeping her alive. And the dialogue, especially, Wilson: "Just a little longer." Amber: "We're always going to want just a little longer." and Wilson: "It's not okay. Why is it okay with you? Why aren't you angry?" Amber: "That's not the last feeling I want to experience." - and Wilson kissing her so that it isn't.
Just the fact that it was Wilson showing such raw emotion when he's usually cast as the straight man.
House's recovered memory of what happened. The moment when he realizes that by taking the pills Amber has sealed her fate is heartbreaking. And having to explain to Wilson that there is nothing to be done...
All the team comes to say goodbye, the bit where they were clinging to each other and having their last conversation, and the bit where Thirteen's Huntington's test shows positive.
The look on Cuddy's face when House wakes up.
"What is my necklace made of?"
And the beginning of the fifth season when he told House they'd never been friends? Hugh Laurie makes House look like a kicked puppy at times.
The second part of season 6 opener "Broken" has a few, when the man who thought he was a super hero gives another patient a music box that makes her say "thank you" the first words she's spoken in over 10 years and near the end of the episode when House's room mate from the mental wards says he wants to take his pills and get better after House leaves.
Because House is usually such a jerkass, the moments when he's vulnerable/human are that much more striking. Take, for instance, the scene in "Skin Deep" where he's asking Cuddy for some morphine. He drops his trousers and cane, shows her the ugly scar and says, near tears, "I could swear I remember a thigh muscle being here".
The end of "Honeymoon". It's near impossible not to feel a massive wave of sympathy in the scene where he tries to walk properly but instead collapses on a nearby chair in agony.
"Half-Wit", with the idiot savant concert pianist who gets half his brain removed. "Are you happy?"
The end of "House Training". Foreman has just managed to kill a patient (she died of a fricking bra infection!) and goes home to his mother, who has Alzheimer's, for some reassurance. It's all going along swimmingly as she hugs him and says she forgives him. The next words out of her mouth? "My little boy's name is Eric." His face crumples in despair.
"Aren't you ever gonna leave?" "No."
The episode "Histories", where a homeless woman sent to the hospital after collapsing. At the end after they find out she has rabies so advanced there's no hope for survival, Foreman and Wilson go to investigate her past using her comics as a guide. They find out this 'James' she kept talking about was her son, who died in a car accident that also killed her husband, and that she felt guilty ever since. After realizing what happened, Foreman, enters her room, claims to be her husband, and tells her he forgives her. She breaks down crying.
The two-parter "Euphoria", especially the second half. For so many reasons.
"Three Stories". Especially this piece of heartbreaking conversation in one of the flashbacks:
Stacy: We've got to let him cut the leg off.
House: (in massive amounts of pain) It's my leg. It's my life.
Stacy: Would you give up your leg to save my life?
House: Of course I would.
Stacy: Then why do you think your life is worth less than mine? If this were any other patient, what would you tell them to do?
House: I would say it's their choice.
Stacy: What? Not a chance! You'd browbeat them until they made the choice you knew was right. You'd shove it in their face that it's just a damn leg! You don't think you deserve to live? You don't think you deserve to be happy? Not let them cut off your leg? (They're both near tears.)
House: I can't, I can't, I'm sorry.
The treadmill scene in "Cane and Able". To see House like that - close to crying because of all the pain he's in but still running anyway - is just excruciating for the viewer.
Soon after the beginning of the Season Five episode "Simple Explanation", Kutner is found dead in his apartment, having committed suicide for no known reason. The biggest Tear Jerker comes at the end of the episode, where a montage depicting Kutner's funeral is shown, including a shot of Taub breaking down as he sits alone in one of the hospital corridors. As if that weren't enough, the montage ends with a black screen showing contact details for mental health organisations and an "If you are thinking of suicide..." message.
The last ten or so minutes of the season five finale, especially the very end, when Wilson drops House off at the psychiatric hospital.
The season 2 finale, "No Reason." Four words: "You're miserable for nothing."
"Birthmarks": "Wilson? My dad's dead."
House starting to crack when he's speaking at the funeral.
The scene in "Wilson" where Wilson asks House if he'll be there for his liver surgery:
Wilson: The operation is in two hours and I'd like you to be there.
House: Because if you die, I'm alone.
And then he goes anyway. It shows that in the end, House cared for Wilson's feelings more than his own.
The first season episode "Babies and Bathwater" features two successive impossible choices for a pregant mother and her husband. The team struggle to save the mother and child...and fail. The baby's cries at the end are the epitome of the tear jerker.
It gets even worse in "Forever". The mother's cancer caused her to kill her child and the father is so traumatized as well that he doesn't even try to convince her not to let herself die.
The episode "Maternity", because it featured the first patient to actually die on the show: a newborn baby. Then there's the scene right afterwards, when Cameron and Wilson go to tell the parents that their baby has died, the sight of them breaking down in each other's arms is only made worse by the lack of audible dialogue.
There are a few moments in the episode "One Day, One Room", especially at the end when House says, "It was true."
"Lockdown", when House's would-be patient calls his daughter and leaves his message.
"Joy", when after all the stuff Cuddy went through she still doesn't get the baby.
In the season 5 episode, "Emancipation", when the poor girl reunites with her parents.
"The Dig" in season 7, when 13 confesses she assisted her brother's suicide. The whole episode was a massive tearjerker, what with House hearing 13 crying in the night, and when she lashes out at him in grief for his percieved lack of emotions.
"I have cancer."
Made even worse by the fact that House had just been abandoned again by a woman he loved, and had come to Wilson seeking comfort, only to hear this.
The following episode, "The C-Word", has Wilson breaking down as he pores over gifts from dead patients who statistically should have made it, and the suffering and insanity he suffers during his chemo.
The penultimate episode "Holding On", where Wilson has only five months to live and House is begging him to undergo chemo, which will extend his lifespan to a few years but comes with pain and being mostly hospitalbound. And when House and Wilson finally come to terms and are planning how to spend the last five months of their friendship House is told he violated his parole (with a stupid prank on Foreman that resulted in severe water damage to the hospital and destroyed an MRI machine) and has to go back to jail. His sentence? Six months.
Wilson breaking down crying in his car begging House to tell him that he loves him and his life was worth it.
In "Everybody Dies", House's death and funeral, at least until you realize he's still alive.
In "Guardian Angels," when the patient that sees her dead mother accepts that it's a hallucination and says goodbye to her. The music during that scene really doesn't help.
House's rant in Season 8, episode 21 about how every waking moment is pain for him due to his leg and that he's considered ending it before.
In season four, 97 Seconds, the dying patient requests his assistance dog, gets Thirteen to place his hand on the dog's head, and then with his last breath tells the dog: "Don't get scared."