Leslie Hope and Sarah Clarke, who played the female leads in the first season of Fox's other big hit of the early 2000s, 24, each appears as a patient of the week in the first season, and both have fates that mirror those of their 24 characters. Hope, who played Teri Bauer, plays the first patient in the series to die on House's watch, while Clarke, who played Nina Myers, pulls a Karma Houdini.
The Sarah Clarke's character did die in a later season of 24.
In one episode, Blackadder can be seen on House's list of Tivo'd shows.
Cameron: Then come up with a cunning plan and fast!
The dual-joke of House showing up to an 80s party in Regency period costume, referencing Blackadder the Third.
And occasionally he will imitate a posh English accent, which is ironically LESS of a departure for him as an actor.
Also, at one point House prescribes someone cigarettes for management of irritable bowel syndrome. It's hard to imagine this isn't a reference to the sketch on A Bit of Fry and Laurie where a man named Pepperdine who looks suspiciously like House gets a prescription for cigarettes.
In one episode Jolene Blalock plays a porn star who mentions that emotions are emotions and sex is mechanical, and there's no reason to overlap the two.
In another episode, Taub comments that he figured Foreman's house would have a more "Mod Squad" kind of feel.
Season 7, Episode 17 wasn't the first time Chris Marquette and Amber Tamblyn worked together. They have a lot of appropriately intimate scenes between them.
It's very brief, but, while discussing various possible diagnoses, House says that one is lower and "lonelier," possibly a reference to a line from Snowbell cat in Stuart Little 2.
Ascended Fanon: The Portmanteau Couple Name"Fourteen/Foreteen" was invented for the Foreman/Thirteen pairing, natch. This is an Official Couple, and that particular name has an added connotation (fourteen = thirteen + one), so House has used that portmanteau name. He does not want them shipped, but...
The 15-year old model in "Skin Deep" is played by a then-27 year old actress.
Cuddy's daughter is usually played by a much older child actress (looking about four or five) but is treated as though she's two. This is pretty jarring as it looks like the child has developmental disabilities.
Fake American: Hugh Laurie as Dr. House. His American accent is one of the better examples, though the way he pronounces some words can give it away. Strangely, he keeps the accent even when he's screwed up lines, as can be seen in the outtakes. When executive producer Bryan Singer saw Hugh Laurie's audition tape, he turned to the casting department and said, "See? This is an American actor!" The casting department had to correct him.
Lampshaded in season one when House calls a doctor in the early hours of the morning. When asked to explain why he is calling at such an early hour he "puts on" an English accent and pretends he was calling from the UK and hadn't considered the time difference. For this scene Hugh Laurie is of course putting on the silly voice he used for oddball sketch comedy in the '80s.
Like most fake-American accents, Laurie uses a "gruff voice" as a cover-up in order to fake an American accent over his British — à la Bob Hoskins in Who Framed Roger Rabbit, and John Mahoney on Frasier; not coincidentally, they're all playing stereotypical "tough American detectives" who supposedly all speak in gruff Midwestern dialects.
Michelle Trachtenberg (best known for playing Dawn Summers on Buffy the Vampire Slayer) guest starred in the episode Safe. She's admitted to having a crush on Hugh Laurie and wrote "I love you" on her inner thigh before a scene where he'd seen it. We might be getting to Stalker with a Crush territory with that.
A number of Squinterns show up late in the third season. Since they hadn't yet shown up on Bones, and since the two shows appear to have nothing in common apart from both airing on Fox, this could just be a coincidence. Still:
3x18, "Airborne", Arastoo is the guy on the plane who doesn't speak much English who House uses as a stand-in for Foreman.
3x19, "Act Your Age", Daisy is the teacher/girlfriend of the patient's father, and Fisher is the patient who can't pee in public bathrooms.
McLeaned: When Kal Penn left the show to serve in the Obama administration, the producers had his character, Kutner, commit suicide. Though this was due to the first reason, not because of any friction with the rest of the cast. They just wanted some drama and a Very Special Episode. The director later joked that if he'd left for another acting role, the death would have been autoerotic asphyxiation.
There was an Itchy and Scratchy segment with the mouse in House's role.
Lisa was seen/heard watching the show and mentioning that Dr. House and his team are about to make a final diagnosis.
Romance on the Set: Jesse Spencer and Jennifer Morrison, who play Drs. Chase and Cameron. They were at one point engaged to be married, but called it off shortly before the wedding. Meanwhile, in a case of Real Life Writes the Plot, their characters also got together romantically... but the plot didn't catch up to their real-life breakup, so the actors were filming proposal and wedding scenes well after they had broken up.
Superlative Dubbing: The Spaniard dub is one of the best in an American TV series in recent memory. Specially House's voice actor, Luis Pórcar. Eventhough his voice doesn't sound like Hugh Laurie's (although it fits him, nonetheless), his performance is so good that even a lot of people that are normally against dubs watch each episode twice: once in English and once in Spanish. All just to enjoy both voices.
This is specially surprising considering that, due to the huge popularity the series has in Spain, they have to dub every chapter insanely quickly in order to not lose TV audience when they broadcast it.
Under Age Casting: Doctors typically graduate from medical school at twenty-six. However, Olivia Wilde was twenty-three when she started on the show as Thirteen. Similarly, Jesse Spencer and Charlyne Yi were both twenty-five, and Odette Annable was twenty-six (the character had previously worked as a prison doctor and therefore, was obviously not straight out of medical school).
Felicia Day auditioned for the pilot. She showed up as the POTW in a season 5 episode.
Patrick "Dr. McDreamy" Dempsey originally auditioned for the lead role.
A physical deformity or handicap was always part of the character design for House, but early versions of the show put him in a wheelchair rather than giving him a bum leg; this was thrown out because it limited the character but showed up in the episode "Needle In A Haystack", where House tries to go a week in a wheelchair as a bet. In another early character design, he had a giant scar on his face.
"Chasing Zebras" was an early working title for the show, after the common med-school saying "if you hear hoofbeats, you think horses, not zebras" (i.e. a simple, mundane explanation for a group of symptoms is likelier to be right than an exotic or complicated one).