This is based on opinion. Please don't list it on a work's trope example list.
Tear Jerker / Final Fantasy XII
The end of the opening FMV, which shows the death of Crown Prince Rasler and the mourning of his wife, Ashe. You may not know anybody at this point, but the scene is enough to bring someone to tears when you take into account that the their wedding was shown literally minutes ago, and later scenes confirmed that they didn't get to share their wedded life for very long. Then you learn that while their marriage was arranged, the couple absolutely loved each other.
The end of the Prologue, when Reks calls out his brother's name before dying.
Later, Vaan has a dream after the Rabanastre break-in, where it's revealed that Reks survived long enough to meet his brother and told him and everyone else about how Basch is a traitor. His expression is that of not only sadness, but disappointment, and it didn't change even when Vaan brought in his favorite flowers, the Galbana lilies (which in retrospect also made the scene where the lilies got trampled earlier sad).
Vaan's angry lash-out against Basch in Nalbina Dungeon. He may not know that it's not Basch who killed Reks and betrayed Dalmasca, but from his point of view, he just met with the murderer of his only living family. From his dialogue, he sounds like he's on the verge of crying.
Basch's Trauma Conga Line, really. Not only did he witness both of his prince and king die before his eyes and all of his comrades slaughtered, his identity was taken by his identical twin who proceeded to make him branded a traitor of Dalmasca. Then he's tortured for years in a horrible dungeon until a bunch of bandits freed him, and even then, there's still a long way for him to clear up his name as people after people lash out at him for apparently betraying their trust. Even at the end, Basch's name isn't cleared up completely since an information that has been planted for two years can't be gone in a blink of an eye, many people still think that he's already executed, and thus he has to find peace elsewhere by taking his brother's position as Judge of Archadia.
The scene that plays upon your return to Eruyt Village after rescuing Mjrn. To sum up: Mjrn, having seen the world outside of their home, begs her sister, the Viera leader Jote, to change their isolationist and essentially xenophobic ways. Fran, however, convinces Mjrn to stay so she'll never have to deal with the same pain and loneliness she went through by abandoning the Wood. This leads Mjrn to run off crying. Fran then asks Jote if the Wood hates her and, after speaking to it, Jote replies that it doesn't. Fran's reply before leaving is quite solemn: "A pleasant lie, that."
Even worse, it is heavily implied that the Elder Wyrm you fight shortly after this is in fact a manifestation of the Wood itself, created specifically to punish Fran for "betraying" it.
The death of Judge Drace at the hands of Gabranth, who is forced to do it to prove that he's not in league with her. Her last request is for him to take care of Larsa, now that the young prince has enemies from everywhere in the higher ranks. This may what push him to finally rebel against Vayne in the climax of the game.
After Judge Bergan is defeated in Mt. Bur-Omisace, the devastation is terrible. Talking to the wounded refugees and seeing the burning of their tents in the distance only adds to the Player Punch. But the final blow is the sad music that plays in the background.
The fate of Nabudis. Since it's never shown in the story proper, the player may be left wondering what kind of destruction that would raze a whole city to the ground. Then you accidentally stumble upon two strange zones to the northwest of the Salikawood while busy locating the moogles to fix the broken gate and realize that the foggy and swampy valleys you see, the haphazard netherworld-like ruins you traverse through, are what remains of Nabudis.
Not only Nabudis. A whole country is shattered when its capital city got wiped completely off the map. Now Nabradia only acts as a staging point for hunters and travelers on the way to Archades, or else inhabited by lost refugees who has nothing to live in or set off to.
Throughout the game, "Nabudis" seems to be employed as a magic word that instantly humbles the recipient and makes them think twice about their position. Reddas in particular is fond of it; not surprising, since he was the person responsible for its destruction in the first place.
Reddas: (to Ashe) Do not forget Nabudis. That is my only counsel for you.
"Hadn't you best be off, fool of a pirate?" Even if you were meant to hate Cid, his death has a way of making you terribly upset, even if it is short.
All of him is a Tear Jerker. Balthier recounts how, years ago, the man was a good father and devoted to his family... until he began researching the stones. And by the end of the game, we've learned that this was because Venat chose him to carry out his plot, and Cid himself believed he was doing the right thing freeing humanity from the Occuria. So, we're subtly told that Cid went insane and neglected his family because he wanted to make a better world for them... even if he was too far gone by the end for it to make any difference.
This exchange between Basch and Judge Gabranth after the party's second boss fight with the latter:
Gabranth: *pants and points a sword at Basch* Have you your fill of this?
Basch: I would ask you the same. Let this end... Noah.
Gabranth: *falls to one knee and sighs wearily* I've no right to be called by that name.
Basch: Then live, and reclaim it.
And he does indeed: he fights alongside your party during the second stage of the final boss fight with Emperor Vayne.
When Judge Gabranth dies in the ending, and asks his brother to look after Larsa, the only person he cared about...
Admit it, his entire back story is extremely tragic in nature.
Balthier and Fran's Heroic Sacrifice at the end to stop Bahamut from crashing down on Rabanastre. Sure, they are revealed to be alive and well at the end, but the context of the scenes make it seem that they wouldn't survive, complete with Fran being knocked unconscious, Balthier deciding to sit down with her to Face Death with Dignity, and Ashe's almost-crying begging for him to get out.
The position that Larsa endures throughout the game. His wisdom makes it extremely easy to forget that Larsa is still 12 years old, a minor who has to adapt to the complex politics of not only Archadia, but the world as a whole. The one time his facade cracks, when he receives news that his father has died, unknowingly by his brother, he shuts down and can't respond to anything. Then in quick succession, Vayne and the two Judges he's closest to, Drace and Gabranth, die as well, leaving him with nothing but himself and Basch's help as he's crowned Emperor with the daunting task of managing the decolonization efforts and peace treaty with Rozarria. One wonders how he's able to keep his mind straight.
Fury's death scene.
In Final Fantasy XII: Revenant Wings, after having spent most of the game opening up to you and regaining his anima, when Llyud performs a Heroic Sacrifice, and takes an attack from Feolthanos meant for Vaan, although he survives, Llyud is striped of the anima he spent the whole game regaining. He's just an emotionless shell again. What makes this worse however, is if you go an talk to Llyud on the Bridge, or in the Sky Saloon, with him only saying that it "feels like a fire inside [of him] has gone", "words elude me", and the worst one of the lot: "..." Not only is it a Tear Jerker, it's a pretty darn big Player Punch too.
Earlier, there's the night where the party learns the truth about Velis, the man that they've been guarding since they became stranded, and who has been warming up to Penelo ever since they met. He is already dead. Not only that, but he used to be the Judge of Wings' lover, and she personally turns him into Odin and makes him fight you. Just before the battle, Penelo breaks down, unable to bring herself to fight him, and at the end of the battle, the party can't bring themselves to put him out of his misery. So Llyud, who has realized at this point that he is devoid of emotion, does it himself. Even worse, after that, Penelo breaks down crying, and Llyud says "I cannot even understand why you cry".