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Tear Jerker: Final Fantasy X-2
The whole point of the game: Yuna searching all of Spira to find Tidus, spurred by hopes that he is still alive somewhere. Doubles as a Crowning Moment of Heartwarming.
Yuna's nightmare, wherein she and Tidus are chased and gunned down in the same way Lenne and Shuyin were.
The Sad ending. 'Nuff said.
The sidequest in Luca where Yuna follows a floating moogle around. Each time she catches up to it, she recalls a memory she had with Tidus there.
Yuna being forced to fight and defeat each of the Dark Aeons; especially the first one, Bahamut.
After Yuna falls into the hole at Djose Temple and is calling out, if you press X, you will hear a familiar whistle. Yuna tries to look for the source of it, asking "Where are you?..." Keep pressing X.
After the infamous "I don't like your plan. It sucks," quote from Yuna in the game's finale, most people are too busy laughing at the scene to pay much more attention. If you actually do, Yuna fully expands on her thoughts in a heart-wrenching speech about how much she lost in the past and how much she deeply regrets all of the noble sacrifices made by her friends (complete with hearing the voices of many of those who made such sacrifices), and how she doesn't want to have to suffer through that regret anymore. The fact that "Yuna's Ballad" plays after Bahamut asks Yuna to forgive him and the other fayths for what they had to put her through makes this scene more poignant.
Yuna: Your plan is awful. Think about it. It’s no different than what we did two years ago. We destroyed our own allies. We destroyed the aeons who had fought together with us, at our side. We didn’t have a choice then. We believed that was the only way we could save Spira. Do you know what it felt like to watch them die? Right before my eyes? It was the only thing we could do. It was the only choice we had. I gave in, I accepted, I believed. I allowed it to be true. I thought I’d be able to go through with it without ever doubting myself. But I… it hurt so much.
Bahamut: Forgive us.
Yuna: Everyone was so happy. “Great job, Yuna. You did it. You saved us all.” There were too many smiles to count. And I know that I was smiling too. But now… when I look back… The people who should be here aren’t. The ones who should be smiling with me aren’t here.
Jecht: We had no choice.
Yuna: “We had no choice.” Always “we had no choice.” Those are the magic words. We repeat them to ourselves again and again. But you know… The magic never worked! The only we’re left with is regret.
Jecht: Yuna… I’m sorry.
Yuna: No. I don’t want this anymore. I don’t want friends to die… or fade away. I don't want battles where we have to lose in order to win.
"1000 Words". Pretty surprising given that FFX-2 is easily one of the most lighthearted RPGs in recent memory.
When Lenne and Shuyin get gunned down in the this song/flashback.