Final Fantasy X-2 may not have many of these, but there is at least one, courtesy of Yuna in her bluntest line ever, when Nooj describes to her how he'll get re-possessed by Shuyin allowing them to kill the unsent:
Auron gets yet another epic one-liner in a treasure sphere (Gippal's Sphere/"Jackasses", if you were wondering): "Only a jackass can change the world."
The Gullwings raiding Kilika Temple at the end of Chapter 1. Yuna fully reveals her new personality and decides to steal the sphere, with a triumphant feel. After fighting her way through the crowded forests to the temple, they have to fight a giant, impossibly-tough looking boss. This is the real Moment of Awesome, when they take the Awesome Sphere. Everybody there is genuinely shocked as they escape back to the airship while basically giving them the middle finger.
Completing the Bonus Dungeon Via Infinito, which flat out requires you to be level 99 to do so. With all the super tough bosses - some of which flat out ignore abilities that should protect you from status effects - getting to the end and taking down the final boss is a massive achievement.
Along with the above, getting 100% Completion. To say it is difficult is an understatement, especially in the International/HD versions which take the amount of things you need to complete up higher. Better yet, do this in one playthrough. Without a dedicated walkthrough and save scumming, it's nigh impossible...but it's still possible. There's something very satisfying about getting 100% with how difficult it is.