- The 7D: Chuck Norris, Tails, and five other dwarves defend the queen's kingdom from Mordecai and his wife.
- Adventure Time: Logan and the Hulk have adventures with Princesses Gretchen and Mort. They sometimes fight Spinelli the vampire queen.
- The Adventures of Jimmy Neutron, Boy Genius: Buttercup, the daughter of the Dark Lord Chuckles the Silly Piggy and Mrs. Puff, is an inventor who hangs out with Max Goof and Krillin. Bridget Jones and Yin are Buttercup's rivals (especially Yin).
- Adventures of Sonic the Hedgehog: Jason Bourne is a speedy dude who works with his friend Anakin Skywalker to stop the schemes of Bones McCoy and his minions Kowalski and Flutterguy.
- All Hail King Julien: Pepe Le Pew inherits the throne from his uncle Mr. Blik.
- American Dad!: Batman (an FBI agent) marries Princess Celestia. They have two children; Numbuh Four and Marceline.
- The Angry Beavers: Yakko Warner and J.D. are brothers who live together. Pops is a Mexican wrestler.
- Yakko's supposed actual "brother" Squilliam visits in one episode.
- Animaniacs: Wilt, Ferris Bueller, and Terra are three song-loving cartoon siblings who finally break out of the Warner Brothers Tower and into the care of Barnacle Boy.
- Pinky and the Brain: Megatron is a mouse who aims to take over the world, along with his dim-witted assistant Brooklyn.
- Aqua Teen Hunger Force: The Joker, Sheldon, and Wulff Yularen share a home in New Jersey. Starscream is their neighbor.
- Avatar: The Last Airbender: Moblit, the last of his kind, is discovered by Raven Baxter (later Sari Sumdac) and her brother Li Shaoran. Alice later joins them, but Chris Turk and his uncle want to capture Moblit. In the end, everyone teams up to battle Turk's sister Gaz and their father Starscream.
- The Legend of Korra: Mabel Pines, the reincarnation of Moblit, is taught by Chowder and Sari's son Mace Windu. Mac and his brother befriend Mabel.
- Beavis and Butt-Head: Robin the Boy Wonder and Tuco Salamanca are a pair of none-too-bright teenagers.
- Ben 10: Adam Lyon can shapeshift into various aliens. He travels with his cousin Riley Daring and their grandfather Soundwave.
- Ben 10: Alien Force: Adam has now become Franklin. He and Riley are joined by Franklin's old rival Handy Manny.
- Captain Planet and the Planeteers: From North America, Steve Stifler, with the power of fire. From Asia, Chuckie Finster, with the power of water. With three other teenagers, they summon Earth's greatest champion... Rocko!
- The Cat in the Hat Knows a Lot About That!: Discord takes Billy, Sally, and Gomamon on science field trips.
- Catscratch: Rico, Guilmon, and Motor Ed are three cats who live with their butler.
- Codename: Kids Next Door: Cosmo, Simon, Susan Test, Spike, and Officer Jenny form a team of crime-fighting children.
- Cow and Chicken: Somehow, Patamon and Discord have human parents.
- Danny Phantom: Troy Bolton has ghost powers. He hangs out with his friends Ferb and Misty. Troy's father is Buzz Lightyear.
- Darkwing Duck: Dr. Evil has a Heel–Face Turn and adopts Sailor Moon, and they live with a pilot named Nick Fury. Evil has to fight crime lord Kent Brockman, electrician Crush, water-based Flash Gordon, plant-based Columbo, and toymaker Young Obi-Wan. Sailor Moon's friend next door is Isabella, and her father is Winnie the Pooh.
- Dexter's Laboratory: Robbie Rotten is a boy genius, and Pinky is his rival.
- Dragon Hunters: Bugs Bunny and Jack Kahuna Laguna hunt dragons, and live in an inn run by Sarabi.
- Drawn Together: Gwen Tennyson, Professor Birch, Honker Muddlefoot, Sam Manson, Martin Prince, a Leprechaun, Joe Swanson, and Seth Cohen share a home.
- Ed, Edd n Eddy: Lazlo, Mikey, and Beast Boy have misadventures in their neighborhood. Gwizdo is the neighborhood bully.
- The Fairly Oddparents: Shinji Ikari has fairies named Guybrush Threepwood and Lust, who are often targeted by Shinji's teacher, Jack Sparrow. Shinji later has to share his fairies with Susie Carmichael.
- Family Guy: Agent J, Molly Weasley, Jonah Baldwin (later Seth Cohen), Donna Martin, Phineas, and Franky share a home.
- Foster's Home for Imaginary Friends: Izuku Midoriya brings his imaginary friend Ben to a special home.
- Gravity Falls: Pony Joe and Yui move to the countryside, where they meet Grunkle Doc Saturday and handyman Mordecai. Joe has a crush on Gory Fangtel, who works at a gift shop. Hoity Toity is a psychic; Joe competes with Johnny Test for Sweetie's attention; and Nia Teppelin is Yui's Alpha Bitch rival.
- The Grim Adventures of Billy & Mandy: After losing to them in a limbo game, Darkwing Duck is forced to serve the human children Tucker Foley and Flim Flam.
- Invader ZIM: Wheeler arrives on Earth with his robot Hamtaro just so he can Take Over the World to please the Almighty Tallest (Cobra Bubbles and Brain). Wheeler attends school taught by Wuya; his classmate and enemy is a paranormal investigator named Conan Edogawa, brother of Lizzie McGuire and son of Old Spock.
- Harvey Birdman, Attorney at Law: Frylock is a lawyer for cartoon characters.
- Jakers! The Adventures of Piggley Winks: Freddie Benson, Turk, and a duck have adventures on their farm.
- Jimmy Two-Shoes: Gunther lives in the Hell-like town of Miseryville, which is ruled by Dr. Drakken. Wendy Corduroy is an evil genius who works for Drakken but has a crush on Gunther.
- Johnny Bravo: Kowalski always fails to get the girls.
- Johnny Test: Jaden Yuki is an 11-year-old boy who hangs out with his pet Stan Smith. Jaden's older twin sisters, Sam Puckett and Black Widow (later Numbuh 3) test their inventions out on him, and they have a crush on Kick Buttowski.
- Kick Buttowski: Prince Zuko is a suburban daredevil; Scaredy Squirrel is his immigrant friend, and Bloo is Zuko's brother.
- Kid vs. Kat: Shinji Ikari is at war with his pet cat.
- Kim Possible: Ariel and SpiderMan, under the orders of Sheen Estevez, must fight Slade and other baddies. At school, they are managed by Harvey Birdman.
- The Lion Guard: Linus, Marcus Abbott, Fee, Scaredy Squirrel, and Don form a superteam. Mr. Collins is king of Pride Rock, with Truman Capote as his majordomo.
- The Looney Tunes Show: Bobby Hill and Wesley Crusher share a home. T.K. has a crush on Wesley, and Queen Chrysalis crushes on Bobby.
- Mia and Me: Alex Dunphy (later Sabrina Spellman) gets a present from her aunt, a game that transports her into the fantasy world of Centopia.
- Miraculous Ladybug: Applejack (whose kwami is Pinkie Pie) and Orlin (whose kwami is Ezra Bridger) fights Harmon Rabb Jr.'s Akumas.
- Harmon Rabb sends his akuma to corrupt people such as Dionisio "DJ" Juárez, Princess Anna, Boomer, Garnet, Bolin and Mantis.
- My Life as a Teenage Robot: Marlene is a teenage robot built by Mayor Mare. Marlene's best friends are the human brothers Double D and Dib; Timmy Turner has a crush on Marlene.
- PAW Patrol:
- (Nickelodeon dub) Kaos leads a group of dogs, including Samwise Gamgee, to help their community and their friends, such as Grover the animal researcher and Majorina the pet groomer.
- (RTL dub) Pepper Clark helps out her community, including Miss Fortune the mayor and Eruptor the grocer.
- The Penguinsof Madagascar: Vanilla Ice, Stimpy, Prowl and Zim are spy penguins who live in the Central Park Zoo. Beth Cooper is their best friend, while Cell (along with Shredder and Blurr) are their rivals.
- Pet Alien: Near welcomes some aliens into his home.
- The Powerpuff Girls: Orel Puppington, Barbie and Fujiko Mine (who were created by THX 1138) save the day before bedtime, fighting Jean-Bob, King Julien, and the Riddler.
- Phineas and Ferb: Stewie and Billy make inventions in their backyard. Lisa Simpson has a crush on Stewie.
- Recess: Jim Hawkins is a fun-loving nine-year-old who's the leader of a six-man team at his school. His friends are athletic Daggett, tomboy Chloe Flan, genius girl Sharpay Evans, over-dramatic Sokka, and shy newcomer Spike. Ryoji Kaji rules the playground.
- Regular Show: Eddy and Snails work for Rover, alongside Jake, Skipper, and the Humbug. Skipper's girlfriend is Lezah, and Snails' girlfriend is Katniss Everdeen.
- Ren & Stimpy: SpongeBob SquarePants and Johnny Bravo do gross stuff.
- Alternatively: Bill Gates and Steve Jobs do gross stuff.
- The Replacements: Monkey D. Luffy and his sister Gwen Tennyson are red haired kids who call their uncle to replace troubling parents. The kids live with their adoptive parents: a secret agent named Xena and a daredevil named Major Monogram.
- Rocko's Modern Life: Skeeter Valentine lives in O-Town. His friends are Houki (who was adopted by Cyril Sneer and Smurfette) and Chas Finster.
- Samurai Jack: Cyborg is a noble warrior.
- Sanjay and Craig: Timmy Turner owns a pet talking snake named Mordecai.
- Scaredy Squirrel: Jimmy Two-Shoes works at a grocery store run by Beast Boy.
- The Secret Saturdays: Ichigo is the son of Optimus Prime and Gatomon. Alongside Gatomon's brother they fight Argost.
- The Simpsons: Sam the Eagle marries a queen ant (later Dory. They have three children: Kenny, Dizzy Devil, and a baby.
- SpongeBob SquarePants: Piglet lives in a pineapple with his pet snail. Sabretooth (later Po) and Vulture (later Jacob Scribble) are his neighbors, Benjamin the Elephant and Kimura (later Colossus) are business rivals. Starfire is Kimura's wife, Bubbles is Piglet's Texan friend and Stifler's mom is a boating teacher. Dexter sings the theme song and narrates, while Master Roshi is an elderly superhero whose sidekick is Jerry the Bellybutton Elf. Benjamin's daughter is Starla.
- Jerry was Arthur Abbott for a while.
- Star Wars: The Clone Wars: Sheen Estevez is a Jedi trained by Barney Stinson who now has an apprentice of his own, Yoko Littner. Their war against the Sith is narrated by Sentinel Prime.
- Superman: The Animated Series: Iron Will is a man of steel.
- Teamo Supremo: Juni Cortez, Violet Baudelaire, and Harry Potter are superhero kids.
- Teenage Mutant Ninja Turtles (2012): Superman is the mentor of martial artists Johnny Test, Randy Taylor, Fanboy, and Jack Darby. Bella Swan is their ally.
- Teen Titans: L recruits Chelsea Daniels, Clarissa, Master Mantis, and Rigby to fight crime. The Sixth Ranger is Dot Warner, but that fails. Their main enemy is The Brain.
- Uncle Grandpa: Star-Lord, Captain Arrow, Scaredy Squirrel, and Eduardo go on adventures with kids.
- Wow! Wow! Wubbzy!: Rarity has adventures with her friends Azula, Sandy Cheeks, and Theodore.
- Wunschpunsch: Trunks and J. Thaddeus Toad save the city of Megalopolis on a daily basis.
- Yin Yang Yo!: Bloo and Bubbles are twin martial artists.
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