Ralph Breaks the Internet: When Ralph and Vanellope first meet KnowsMore, one of the guesses KnowsMore makes about what Ralph is trying to say to him is "Urkel, played by Jaleel White".
Full House: In "Stephanie Gets Framed", Steve Urkel guest stars, revealing he's the cousin of one of Stephanie's classmates, and gives Stephanie some advice about wearing glasses.
Step by Step: The episode "The Dance" is a crossover with the show, in which Steve lands in the Lamberts' house as a result of his jetpack malfunction at the end of "Brain Over Brawn" (which aired immediately prior to it on their original airdate).
Community: One Halloween Episode has Shirley annoyed that her Harry Potter costume keeps getting confused with Steve Urkel.
Key & Peele: In a very NSFW sketch, Urkel's status as a Breakout Character, and the subsequent total retooling of the show around him, is mercilessly parodied. Jordan Peele plays an irate Reginald VelJohnson, complaining to Keegan Michael-Key's producer character Gene about the increasingly bizarre plots on the show ("Steve Urkel turns Carl into a giant sandwich and accidentally eats him?") and the show completely losing its focus (an upcoming episode apparently has Steve teleporting the entire family to another dimension and turning Carl into an Urkel clone—"That's two Steve Urkels and no family on a SHOW CALLED FAMILY MATTERS!"). Things get REALLY dark when it's revealed that Jaleel White isn't even real—Steve Urkel is apparently a Humanoid Abomination with telekinetic powers that allow him to bend everyone around him to his will.
Mystery Science Theater 3000's season 6 episode "San Francisco International", Mike Nelson spends every mid-movie host segment pretending to be Urkel, to the utter delight of everyone who sees him. It finally stops when Torgo stops by and admits to having never been a fan of the character.
In his review of the Dennis the MenaceLicensed Game for the SNES, the Nerd calls Dennis the original Steve Urkel, due to both Dennis and Urkel causing huge problems for their next-door neighbors (Mr. Wilson, Carl Winslow) despite meaning well.
Board James: One episode has James and his friends playing a Urkel themed board game.
Console Wars: In the Batman Forever episode, Pat points out that the SNES version of the Licensed Game based on the titular film doesn't have the voice clips that the Sega Genesis version does, but Dan argues that the sound quality of the voice clips on the Genesis version is terrible. Pat then says it's better than what the SNES version originally had planned, and shows Dan fictional voice clips that were cut from the SNES version on the blu-ray of the titular film that Dan ordered, where the enemies say "Did I do that?", along with "You got it, Dude!", and that weird Tim Allen noise.
Third Rate Gamer: The beginning of his Cool Spot "review" has the show's theme song play briefly before being interrupted by the game over music from Super Mario Land.
In "Taming of the Screwy", the Warners throw food Mr. Plotz and Dr. Scratchnsniff. They duck to avoid it, and a wheel of cheese ends up hitting Urkel, who had just asked for some.
In "Meatballs or Consequences", Yakko covers Death's eyes and asks "Guess who?", and he guesses "That Urkel kid?".
In "A Christmas Plotz", Mr. Plotz sees a future where Ralph's son is the studio CEO, and he yells into his phone, "Tell that Urkel guy he's gettin' too old to wear his pants that high!".
Craig of the Creek: In "Trick or Creek", Duane dresses as Steve Urkel for Halloween.
Family Guy: In "The D in Apartment 23", while at a college library and using failed pick-up lines to flirt with a female student, Brian at one point asks, "Did I do that?"
In "Bart Gets Famous", when Bart worries that his saying of "I didn't do it!" is an "obnoxious fad", Homer tries to cheer him up by saying that's what people thought of Urkel, before remembering that he hates him.
In "Sideshow Bob's Last Gleaming", Urkel is among the representatives of television called in to discuss Sideshow Bob's threat for Springfield to end all TV broadcasts.
In "The Springfield Files", Homer compares the alien he saw to Urkel in that it has a "sweet, heavenly voice" and appears every Friday night.
In "'Tis the Fifteenth Season", Bart shows Homer how much TV writers like to spoof A Christmas Carol by showing such an episode of Family Matters.
Ghost: Reform, Ebenezer Urkel! You have alienated everyone who loved you! Urkel: Did I do that?
, Urkel's status as a Breakout Character, and the subsequent total retooling of the show around him, is mercilessly parodied. Jordan Peele plays an irate Reginald VelJohnson, complaining to Keegan Michael-Key's producer character Gene about the increasingly bizarre plots on the show ("Steve Urkel turns Carl into a giant sandwich and accidentally eats him?") and the show completely losing its focus (an upcoming episode apparently has Steve teleporting the entire family to another dimension and turning Carl into an Urkel clone—"That's two Steve Urkels and no family on a SHOW CALLED FAMILY MATTERS!"). Things get REALLY dark when it's revealed that Jaleel White isn't even real—Steve Urkel is apparently a Humanoid Abomination with telekinetic powers that allow him to bend everyone around him to his will.