Parodied in "D.A.R.E. to Resist Ninja Drugs and Violence" where the Doctor directs a pretty awesome speech at Frans Rayner...
Doc: Rayner, you killed my mentor, and you kidnapped my sidekick. I met Death himself last night, and he's going to follow me all the way to your house. You made it personal.
Doc: I'm trying to think of that thing I said earlier today, when I was riding that raptor there, and how Death was mad at me... and somehow I applied it to you? I forget it now. It would have been good. But, uh, whatever. You're like, the lamest Great Dane since Marmaduke, and I'm gonna kill you. Whatever, who cares. Let's go.
Also:
Doc: Hello. My name is Doctor McNinja, and I'm going to be your phlebotomist today. Random mook: Wot's a phlegm botanist? Doc: It means I'm going to draw your blood.
Mitzi McNinja gets one of her own during the "Punch Dracula" Story Arc: "And the dead can't hear their own eulogies. So let's wrap this up.!"
In the Axe Cop crossover, when Axe Cop summons a giant robot suit to fight the bad guy with:
Axe Cop, in the guest story "Revenge on Rainbow Girl", faces off with a giant dragon and says "I'm sorry, but this is too late for you" before attacking. If you're wondering, it's a direct quote from a child's narrating the scene.
In Brawl in the Family, during the Phillips CD-I arc, Waluigi returns from vacation to find a Phillips CD-I making everyone become characters from that game... except Dedede, who's trying not to go insane. He views the situation, and then says "Weh. You call this madness? Step aside.Waluigi time."
Alien: Human! You belong to me. Buck: Thanks, but actually, I belong to me. And I don't share.
Subverted because the alien in question then proceeds to thoroughly kick Buck's ass.
Gordon Frohman of Concerned fails to assassinate Gordon Freeman before the explosion of the combine portal, because he's too busy coming up with a line.
Digger by Ursula Vernon. "Remember Tunnel Seventeeeeen!!!"
In El Goonish Shive, Spider Grace gets called out for reusing these kind of quips by thugs who are robbing a bank.
In Girl Genius Gilgamesh Wulfenbach does pretty well here (starting with the last panel, and continuing the rant through a few pages of the brawl), then attempts one here but fails. Tarvek here reminds us he's trained as a SmokeKnight.
This dialog right before the Final Battle commences:
Dirk: Ask me anything. Go ahead. Dirk: I'll give you a straight answer. Dave: alright Dave: here goes Dave: why are we so fucking awesome Dirk: Dave. Dirk: That's the best fucking question, Dirk: Anybody ever asked.
The angel 82 White Chain begins each fight with reciting a prayer. Disrupting it is a massive Berserk Button.
"Pree Aesma. Ys-Asram, the Blooded One. Ys-Prama, Hansa, and Prat-Pavam, who temper my heart. Yisun Atru Vayam. Forgive me for this violence I am about to inflict."
Subverted when White Chain realizes that she's gone too far and begins the prayer, but ends it with a simple "...forgive me."
Pree Aesma. Ys-Asram, the Blooded One. Prama, Hansa and Pavam, who temper my heart. YISUN. Atru Vayam. I do not ask for your forgiveness. Merely your witness!
"SOLOMON! You think you're safe here? You think this will challenge me? Where is he? If I have to, I'll tear this whole place apart." — Allison again, using all of her energy to intimidate Demiurge Solomon David.
"MISTAKE." — 6 Juggernaut Star Scours the Universe teleporting between Vigilant Gaze and White Chain with the intent to punish the latter for her percieved failures.
A-HA! That did the trick! HO THERE! You there! Blackguard! Enough! God, called YISUN, has entrusted us with the world itself! How can we be as prideful as to judge it? She is the only one of us not afraid of fulfilling her duty, and yet we spurn her! No longer! By my honor as a knight of the holy Concordance UNHAND OUR SISTER!
Jagganoth, finally following through with his threats:
L's Empire has this one after some Whackas have been trapped by an angry Physical God. He doesn't get to follow through on it due to being on probation.
Whacka: "Oh God have mercy!" Dark Star: "No... I won't."
Kevyn: How do you do this "calm in the storm" thing? Tagon: I am the storm.
Brianna from Servants of the Imperium tells Twink "May the Emperor have mercy on your soul... because I will not."
Sinfest: Subverted in a Ninjapiece Theatre strip when Slick, the Pimp Ninja threatens Yellowtail (the Geisha Slut) with "I kill you so hard your ancestors will die!"