- A child suffers Parental Abandonment (a Real Life issue) because his parents Ascend to a Higher Plane of Existence (fantastic cause). Because the cause does not exist in Real Life, the moral ambiguity associated with Real Life Parental Abandonment is removed, without removing the tendency of anyone who has suffered Parental Abandonment to see themselves as the child.
- A character is turned into a monster and imprisoned in an Elaborate Underground Base. If being turned into a monster is the main issue for them, it's Supernatural Angst. However, if being forced to leave their old life is the main cause of angst, it's this.
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Anime and Manga
- In Magical Girl Lyrical Nanoha, Fate Testarossa was not loved by her mother because she was a clone of Precia Testarosa's daughter. Her "mother" is only using her to resurrect her dead sister.
- In Neon Genesis Evangelion, Asuka's mother's soul was "sucked" into a giant robot. As a result, she confused her daughter with a doll and committed suicide.
After that, it's hardly surprising Asuka graces the page image for Jerkass Woobie.
- Also, Rei. Not all withdrawn teenaged girls with little social skills are that way because they were created as a tool to end the world, infused with a soul that once belonged to the progenitor of humanity and raised in a cold, sterile lab with the knowledge that there are clones to replace her even if she dies, but many of them can still empathize with Rei's feelings of loneliness and insignificance, her feeling of being "different from everyone else" and her problems to communicate her feelings - Some scenes from her life look remarkably like those of authentic outcast teenaged girls who were shunned for "mundane" reasons like being a geek, being shy or Intelligence Equals Isolation might encounter, like the way her classmates talk about her, the way she reads science books in a corner and how she is mistreated by more popular girls like Asuka.
- In Anita Blake Vampire Hunter, Anita wangsts over her lifestyle of having sex with hot guys due to being a vampire, and the fact that her lifestyle, profession, and religion are at odds.
- In Harry Potter, the title character is an orphan because his parents were killed by an evil wizard with a magical curse.
- In The Dresden Files, the title character is an orphan because his parents were killed by an evil vampire (probably) with a magical curse.
- Ida from Shaman of the Undead angsts because her parents want to send her to magical academy and marry her off to some important wizard so that she can bear him magical children. Problem 1, she wants to study Muggle psychology. Problem 2, she has no magical gift whatsoever.
- Pact has Evan Matthieu, the ghost of a child who died of exposure while fleeing a goblin, who later gains the ability to shapeshift into a sparrow with magic lockpicking powers after becoming a wizard's Familiar. He expresses that he's kind of glad that he died (being hunted by goblins is hellish), misses his parents and friends (who he can't talk to, being a ghost) and regrets that he never got to finish several video games (he gets help in this from a friend who agrees to push the buttons while he struggles with the joystick).
- MS Paint Adventures
- Homestuck's Rose Lalonde develops an alcohol problems at two points in the comic, once because she's stuck in a Bad Future and the other time because she's anxious about seeing an Alternate Dimension version of her mother.
- Problem Sleuth sees Ace Dick lose his wife to crime, pursue vengeance until his son leaves him for his own crusade, end up lost and alone in a horrid swamp and having lost everything he values in his life, takes his own life. This all happened in an intense game of Life with the Grim Reaper.
- Jonathan Coulton songs are made of this trope, including such things as:
- A song about feeling uncomfortable with all the genetic enhancements one's significant other is getting.
- "I'm Your Moon", a song Charon sings to Pluto so Pluto doesn't feel bad about not being considered a planet anymore
- "I Crush Everything", a song about a lonely giant squid.
- In Young Justice, Superboy has parental issues and lack of parental bonding due to the fact that he is a clone of Superman, who is also having a hard time coping with this fact.
- Avatar: The Last Airbender has a fair share of this, perhaps most notably:
- Aang lost everyone he'd ever known due to being cryogenically frozen, including the only mentor he ever had. As if that weren't enough, because he is the reincarnation of the avatar, it's his responsibility to keep the balance between the nations. He doesn't actually angst as much as you might expect, though.
- Katara and Sokka both long for parental affection because a firebender killed their mother and their father had to go deep into the Serpent's Pass to defend the Earth Kingdom.
- Zuko longs for the affection of a father who kicked him out of his home and expelled him from his own country, as the result of his refusal to participate in the Agni Kai.
- Steven Universe
- Steven, a human-alien hybrid, grapples with mixed feelings about his (alien) mother, who gave up her physical form so that he could be born.
- Steven's parental figures feel like they're failing him because they feel desperately unprepared and have no idea if they're raising him right/the way his mother would have wanted; no other Half-Human Hybrids exist and they don't know how to help him balance his Gem traits with his human traits.