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- Kakashi has a transplanted Sharingan, and is so skilled with it that one of his nicknames is "Sharingan Kakashi". He eventually develops the Mangekyo, allowing him to send anything he looks at into another dimension.
- Similarly, Danzo replaced his missing eye with a Sharingan. On top of that, he implanted even more Sharingan into his right arm so he could utilize their reality-altering genjutsu.
- The Mangekyo Sharingan allows its user to access special high-power techniques, but extensive use renders the wielder blind. The Eternal Mangekyo allows access to those abilities without the downside, but requires the eyes be transplanted from another Sharingan user, preferably one with the Mangekyo activated.
- The First Hokage's cells have become a major source of game-breaking transplants due to their impressive ability to regenerate. Aside from their use in creating Zetsu and his clones, they've also been used to:
- Replace Danzo's right arm.
- Replace Tobi's right arm and leg.
- Replace the majority of Orochimaru's body.
- Act as life support for Madara.
- The Cursed Seal created by Orochimaru is apparently a very small Badass Transplant. It consists of his cells and allows the user to utilize Juugo's bloodline. On a more sinister note, Orochimaru can divide his consciousness among the Seals and regenerate his body using the stored cells.
- Tobi stole the Rinnegan from Nagato's corpse and implanted one in himself, having discovered he lacked the ability to control both eyes at once. Madara later reveals Nagato's Rinnegan was also a transplant, as they were originally Madara's eyes.
- The Rinnegan itself is the result of a transplant. When Madara implanted himself with Hashirama's cells, their unique chakras interacted and recreated the chakra of the Sage of Six Paths, allowing the Rinnegan to manifest.
- The Dragon Slayers of Fairy Tail were taught by dragons to use their Elemental Powers like a dragon would, but the Second Generation Dragon Slayers such as Laxus and Cobra instead have these abilities due to amplifier lacrima implanted into their bodies.
- Tsubasa Reservoir Chronicle. Albeit, only one party was willing...
- Allen Walker's arm in D.Gray-Man, which just keeps getting more badass.
- Clare's new arm in Claymore.
- Technically, any transplant Clare gets is a Badass Transplant, since she tends to get the new parts from badasses.
- Taken to an entirely new level when it's revealed that the transplanted flesh from Teresa is able to Awaken, allowing Teresa to take control of Clare's body and fight again.
- All Claymores become Badass due a piece of yoma flesh which is transplanted into their body. The transplant gradually alters their body until they become the half-yoma warriors.
- Technically, any transplant Clare gets is a Badass Transplant, since she tends to get the new parts from badasses.
- Fullmetal Alchemist
- Scar has his older brother's arm, tattooed with alchemical markings that allow him to destroy anything with a touch. Said brother transplanted that arm on Scar's by himself, with alchemy, to save a young Scar from bleeding out after having been horribly mutilated by Kimblee in the Ishbalan massacre.
- The main character, Edward Elric, wears wears a prosthetic arm that he can transmute into a wrist-mounted blade.
- And then there's Ling getting Greed injected into him.
- In Tengen Toppa Gurren Lagann, Kittan used Gurren Lagann's drill to destroy the Death Spiral Machine.
- Sesshomaru of InuYasha goes through a bunch of replacement arms - including a dragon claw - before giving up on the idea. He only needs one, anyway.
- Guts of Berserk replaces the left forearm that he lost during the Eclipse with a metal replacement that can smash opponents senseless and mount a repeating crossbow. As a bonus, it's got a built-in cannon.
- Hiei from YuYu Hakusho and his Jagan eye. It's an inversion, though; his Jagan actually made him weaker, a lot, it did however gave him some new abilities. It eventually becomes a straight example, as Hiei eventually surpasses his original power level even without taking the Jagan into consideration.
- In Witchblade Takeru a young man was rather shocked to discover that the new skin on his arm is transplanted from his girlfriend. Then that she's already regenerated it. Then that she's a half-demon. It has some interesting effects, including changes on the rest of his arm. But probably worse than it would be if this wasn't the hand with which he wields his magical demon-slaying sword. Oops.
- Ai from Dragon Crisis!.
- The Kamen Rider Spirits version of Riderman. Prosthetic arm? Check. Rope Arm (to grab things at a distance - think Link's Hookshot)? Check. Power Arm (a giant claw)? Check. Drill Arm (go on - guess)? Check. Machine Gun Arm? Check. The ability to chain them together to break through some nigh-unbreakable armor? Score one for the (nearly-)normal guy.
- Legato's Mind Manipulation ability in the anime of Trigun is possible because he has Vash's arm (in the manga, there's another explanation: microscopic wires inserted into peoples' bodies to control their nervous systems).
- Kazuki's powers in Busou Renkin stem from the Kakugane he uses as an artificial heart.
- In Tokyo Ghoul a human young man named Ken Kaneki receives multiple organ transplants from the ghoul Rize Kamishiro and starts to develop ghoulish powers.
- Lobster Random's claws.
- This is the gimmick of the U-Men, a cult of mutant wannabes who hunt mutants for grafts and transplants, such as x-ray eyes or electric blood.
- Jennifer Walters got her powers by way of a blood transplant from her cousin Bruce.
- This was the shtick of Terror from Terror Inc in the Marvel Universe. He could replace lost body parts with limbs and organs taken from other organisms. He then gained the skills and abilities of the person or being to whom the "borrowed" part belonged.
- The supervillain Prometheus in The DCU could via a compact disc allow a download of the knowledge and physical skills of others directly into his brain; his default disc including the skills of thirty of the world's greatest martial artists.
- Deadpool here! Those Weapon X guys tried to cure my cancer with an injection of Wolverine's man-juice (his DNA you pervs), didn't really work, but at least I can't die now.
- Used similarly by Spooner in I, Robot to kill the Big Bad. Also served as both The Reveal and an I Am Not Left-Handed moment in an earlier fight with a robot.
- Evil Dead's Ash and his trademark chainsaw.
- Cherry Darling in Planet Terror who has a machine gun for a leg.
- The MacGuffin in DOA: Dead or Alive was a pair of sunglasses that allowed the wearer to use the combined skills of the fighters whose moves were recorded into the device.
- Deliberately invoked by Tsavong Lah in the New Jedi Order. His people, the Yuuzhan Vong use transplanted limbs all the time, but after Lah's foot gets torn off in a duel, he goes for something special. He kills a Vua'sa [a nearly unkillable predator from his homeworld] with his bare hands and tears off one of its feet to replace his own. His subordinates were... impressed, to say the least.
- Max Barry's Machine Man has Dr. Charles Neumann, who begins with one, then a pair of powerful prosthetic legs that can not only leap tall buildings In a Single Bound, but also kick down re-inforced steel doors. His team also designs powerful arms that end up attached to the Security Guard, Carl.
- The Chronicles Of Corum kicks off the transition of the titular Corum from a pampered noble into a walking disaster zone when he loses his hand and his eye which subsequently get replaced by The Hand of Kwll and The Eye Of Rhynn, which allow him to see into other dimensions and call up undead servants from them. He has to give both up in the end, and settles for a man-made silver prosthetic in his second trilogy of adventures.
- Riderman from Kamen Rider V3 is apparently a normal dude in a powered suit... with a prosthetic right arm from the elbow down. Said arm can change forms into a rope-based arm, a giant claw, and a drill - at least in the live-action versions of him. He's not nearly as powerful as V3 himself, but makes up for it in effort.
- Among the artifact-level magic items available in Dungeons & Dragons are the Hand of Vecna and the Eye of Vecna, which were formerly body parts of a powerful lich. To use one of these items, a character must first remove the appropriate part from his or her own body. Rumors of an artifact called the "Head of Vecna" should probably be disregarded as the invention of a sadistic PC with a sick sense of humor.
- There are also dozens of grafts and symbionts, plus the Half-Golem template, most of which grant some sort of special attack or defense.
- In Hunter: The Vigil, this is the Cheiron group's specialty. What do you want? Demonic eyes that can see into the very depths of a man's soul? Trivial. A personal defence swarm of angry magical insects embedded into your arm? Child's play. A rotten human hand that can shoot fire, and hypnotize those that look at it? Why the hell not?
- Most games that allow cybernetics (Shadowrun comes to mind; even GURPS or Dungeons & Dragons in some settings) will have a player who believes in this, and acts on it.
- Eclipse Phase: The cyberlimb isn't all that awesome, since its sole source of advantage is that it's slightly more armoured than your regular arm, but a cyberlimb plus with cyberclaws, a hand laser, and implanted nanotoxins is a thing you don't want to get hit with.
- You can do this in Genius: The Transgression. It may be a sin against Obligation, but who needs a Karma Meter when you have a massive death talon for your left arm?
- Warhammer 40,000's Space Marines obtain their superhuman abilities via surgical procedures that implant various new organs inside which also give them new features like acid breath and bulletproof ribcages. So important are they that dead Marines are always retrieved from the battlefield in order to save their geneseed which will then be implanted in new Marines (if circumstances allow, otherwise the Apothecaries just rip them back out).
- Possibly the earliest in the medium: Bionic Commando's arm.
- Gene's God Hand in God Hand.
- Fate/stay night has Shirou get Archer's arm (lovingly called GARm in several communities) in the Heaven's Feel scenario, which doubles as a Deadly Upgrade.
- Odd variation here: It's still his own arm, just a bit older. That's the only reason the transplant was successful.
- Planescape: Torment has eyes that act as equipment for the Nameless One. He equips them by ripping out his old one and sticking the new one in its socket.
- Ragna's replacement arm in BlazBlue, formed from the corpse of an Eldritch Abomination.
- And his second transplant. Though not quite to the Eldritch Abomination levels of the Azure Grimore, he receives an arm made from whats left of Lambda 11's regeneration tank.
- Naoto Kurokage gets his right arm replaced that made out a blood of a vampire (twice), what allows him to use his own blood as a weapon.
- Shepard's extensive body modification courtesy of Cerberus in Mass Effect 2 make him/her much, much cooler than normal humans.
- Though, (s)he was notably badass, before that.
- "Meet the Medic" shows us that the Ubercharge in Team Fortress 2 is initiated by implanting the heart of a Mega Baboon with an implant attached in place of the trooper's normal heart (which tends to explode when exposed to the implant's charge).
- Deus Ex: Human Revolution: Adam Jensen is much more badass after having his arms replaced with bionic ones, among other things. Most of them weren't even needed to save his life and were installed for the sole purpose of making him the most badass cyborg created by Sarif Industries.
- Albert Wesker of Resident Evil fame was a genius and skilled soldier at first, but it was the injection of an experimental virus that gave him his super strength, ability to dodge bullets, and overall Nigh-Invulnerability.
- Phoenix Wright: Ace Attorney – Dual Destinies: Apollo Justice does this when his best friend Clay dies, and he suspects Athena of being involved.
- MEC Troopers in XCOM: Enemy Within voluntarily get their limbs amputated... so they can replace their flesh and blood limbs with this thing◊.
- Zokusho Comics: Rotting Johnny takes this to a whole new level. He used to be a hitman, but someone blew his hand off. Just as he was considering exiting life via a shotgun, a mage came to him with an offer of a new hand. The hand worked great. Until it started rotting. Then the rest of his body decided to follow the new hand's lead. On the bright side, he can now graft fresh parts on in place of the rotting ones.
- Michael gets this twice in Ather City. Once, after he loses his right arm and gets a replacement made of brimstone, and then Nick builds him a mechanical version. Even before the transplant he was considered the best fighter in the city. After, it's hinted that he could beat anyone in the series if he wanted to. This is after almost every single character takes one or more levels in one thing or another.
- In the Transformers Prime episode "Alpha and Omega", Megatron has his lower right arm amputated and replaced with one from a deceased Prime, just so he can forge and wield his own version of the Star Saber.
- When Qilby the Traitor from Wakfu reveals himself as the season's true Big Bad, he also merges with the Eliacube replacing his missing arm with one made of pure wakfu. Prior to that, he was too weak to confront the heroes. Afterwards, he shows what an adult Eliatrope who has fully mastered their powers can do.