Any instance where Guybrush uses the ventriloquism book to throw his voice in Part II, but of particular note is when he uses it on the monkey pirate captain and does a Captain Kirk impression:
"I mean, take a look around, at me, at the rest of the crew... We're all monkeys." "You mean in the Darwinian sense, sir?" "No, I mean in the quite literal sense."
Drink immediately begins to bubble and change color. Guybrush: That makes the drink oh-so-much-more appealing. [turns to the camera]] It just occurred to me that mixing medicine and alcohol is a really stupid and possibly lethal thing to do. If I were a real person instead of a loveably inept cartoon character with the potential for a few more sequels... I wouldn't even consider it.[turns back to the drink] Skoal! [downs the beverage] That's odd. It's supposed to cause drowsiness. I don't feel the least bit drowsy. [the scene goes on a trippy Interface Screw] In fact, I... [his voice goes into sleepy slow motion] ...in fact I feel... I feel... He instantly falls to the floor.
Guybrush's "death".
In the sequence where Guybrush fakes his death a second time to get buried in the Goodsoup crypt, hotel manager Griswold Goodsoup offers this gem:
Griswold: Oh, dear! He's had a sudden and completely unexpected relapse of death!
"You fool! You've given cheese to a lactose-intolerant volcano god!"
On that note, Lemonhead in general. "Shut up. Or I'll eat you."
Guybrush: Did I say "cannibal?" I, I meant to say... err, "cannon... ball." I want to be a cannon ball. BOOOOOMM!
Lemonhead: ...You're not quite stable, are you?
Similarly, after the "human sacrifice" to the volcano god (which is actually a dummy made out of fruit), complete with dramatic ritual-saying and rope-cutting, the cannibals stand around the volcano's edge and toast marshmallows.
The "terrifying" shape of Skull Island.
Lost Welshman: Well, ya see... ya gotta squint and sorta turn your head and... Ooooooooh! It's just SO scary!
Guybrush: If you squint and turn your head it looks like a bunny.
Asking LeChuck what the real secret of Monkey Island is.
Stan's triumphant return. Especially if you've played the preceding games.
"I'm runnin' guns!"
LeChimp's Captain turns out to be a mute, dopey looking gorilla modelled after Captain Kirk. Guybrush's Brief Accent Imitation of William Shatner ices the cake.
Guybrush bypassing a Walk the Plank ordered by LeChimp (whose very name is already a joke):
Lechimp: That's weird, I didn't hear the splash...
