Fake American: The Son Pirate from the end credits. Alexandra Boyd performed an American accent perfectly.
Promoted Fanboy: Dominic Armato, voice of Guybrush Threepwood, was a long-time fan of the games. He may have won the role because he was a fan — it was close between him and another actor and his love of the franchise was the tipping point.
Talking to Himself: There are a lot of actors who voiced multiple characters (even though said characters have never met each other). They are: Alexandra Boyd, who does Elaine and the Son Pirate; Denny Delk, who does Murray, Skully and the Father Pirate; Michael Sorich, who does Edward Van Helgen and Charles DeGoulash the Ghost Groom; the aforementioned Terry McGovern; Tom Kane as Captain René Rottingham and the Lost (Flying) Welshman; Harvey Jason as the Cabaña Boy and Effete LaFoot; S. Scott Bullock as Lemonhead and Pirate #2; Victor Raider-Wexler as Slappy Cromwell and the Snowcone Guy; Dave Fennoy as King André and Pirate #3; George DelHoyo as Palido Domingo and Pirate #1; and Roger Behr as Mort the Gravedigger, Stu Boyle and Pirate #4. Even Dominic Armato can have a short "conversation" with himself (he also voiced the incomprehensible restaurant drive-thru speaker).